Research the possibility of the traditional Japanese medicine"Rikkunshito" as the calorie restriction mimetic drug
| Project/Area Number |
22790620
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 東洋医学 / カロリー制限 / 抗老化 |
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| Research Abstract |
Short term treatment of traditional Japanese medicine “Rikkunshito (RKT)” increases plasma acyl-ghrelin, and stimulates food intake via hypothalamic NPY expression. This mechanism is similar to that of calorie restriction (CR). In this study, we investigated the possibility of RKT as the calorie restriction mimetic drug. Chronic RKT treatment increased acyl-ghrelin level, and enhanced oxidative stress resistance like the effect of CR. However, chronic RKT treatment could not extend lifespan. Interestingly, chronic RKT treatment from middle or old age significantly decreased white adipose tissue mass.Although it is necessary to clear more detail condition and molecular mechanisms of RKT treatment at the old age model, it is expected to apply anti-obesity drug.
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Report
(4 results)
Research Products
(8 results)
