Relationship between the nucleotide substitution rate of the hepatitis C virus and the effects of interferon therapy in children.
Project/Area Number |
22790622
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General internal medicine (including Psychosomatic medicine)
|
Research Institution | Nagoya City University |
Principal Investigator |
ITO Koichi 名古屋市立大学, 大学院・医学研究科, 助教 (00444977)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
|
Keywords | HCV / 遺伝子 / NS5B / IFN / 母子感染 |
Research Abstract |
Seven children infected by hepatitis C virus were treated with PEG-IFNα-2a at a dose of 90-180μg/kg s. c., once a week for 24-48 weeks. Six patients completed the treatment. One patient discontinued the treatment at 12 weeks. RVR was achieved in 2(29%) of the 7 patients. EVR was achieved in 7(100%) of the 7 patients. SVR was achieved in 6(86%) of the 7 patients. We isolated HCV-RNA from the sera of 7 children and analyzed the NS5b region. The nucleotide sequences in the NS5b region of HCV obtained from each of the children under treatment were identical to those of before treatment.
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Report
(3 results)
Research Products
(15 results)