Targeting obesity-related metabolic abnormalities for chemoprevention of colorectal cancer and hepatocellular carcinoma
Project/Area Number |
22790638
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Gifu University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 肥満 / 発癌予防 / 大腸癌 / 肝細胞癌 |
Research Abstract |
Obesity-and diabetes-related metabolic abnormalities, including insulin resistance, alterations in the IGF-1/IGF-1 receptor axis, state of chronic inflammation, and occurrence of adipokine imbalance, increase the risk of colorectal cancer and hepatocellular carcinoma. Therefore, improvement of these metabolic abnormalities by either pharmaceutical or nutritional intervention, such as supplementation with branched-chain amino acids, may be an effective strategy to prevent the development of colorectal cancer and hepatocellular carcinoma in obese individuals.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Preventive effects of(-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice2011
Author(s)
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H.
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Journal Title
Cancer Prev Res
Volume: 4
Pages: 396-403
Related Report
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[Journal Article] Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice2011
Author(s)
Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H.
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Journal Title
BMC Cancer
Volume: 11
Pages: 281-281
Related Report
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[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor2011
Author(s)
Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O.
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Journal Title
J Biol Chem
Volume: 286
Pages: 26178-26187
Related Report
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[Journal Article] Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/K sJ-db/db Mice2011
Author(s)
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H
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Journal Title
Cancer Prev Res
Volume: 4
Pages: 396-403
Related Report
Peer Reviewed
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[Journal Article] Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice2011
Author(s)
Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H
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Journal Title
BMC Cancer
Volume: 11
Pages: 281-281
Related Report
Peer Reviewed
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[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepatocellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study2010
Author(s)
Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H.
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Journal Title
Hepatol Res
Volume: 40
Pages: 376-382
Related Report
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[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepato cellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study.2010
Author(s)
Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H.
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Journal Title
Hepatol Res
Volume: 40
Pages: 376-382
Related Report
Peer Reviewed
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