| Project/Area Number |
22790667
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
MIKAMI Yohei 慶應義塾大学, 医学部, 研究員(非常勤) (80528662)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 炎症性腸疾患 / インターロイキン17 / インターフェロンガンマ / クローナルコンペティション |
|---|
| Research Abstract |
In this study, we showed that the interaction between Th17 cells and Th1 cells contribute to altering disease phenotypes. We have also demonstrated that Th17 and Th17/Th1 cells become colitogenic alternative Th1 cells via Th17, Th17/Th1, and Th1-like cells, independently of classical Th1 cells. We have also established that regulatory T cells suppress this pathway, resulting in accumulation of Th17 and Th17/Th1 cells. This alternative pathway, generating colitogenic Th1 cells, could be a new therapeutic target of Inflammatory bowel diseases(IBD).
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