| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We showed that the NKp44+/NKp46+NK cell is balanced in human normal intestinal mucosa, and the balance is disturbed in the intestinal mucosa in Crohn's disease. Moreover, the interaction between intestinal NKp46+NK cells and CD14+LPMφs is an important participant in the pathogenesis of Crohn's disease. IL-23 and the TL1A were the key factor of their interaction. These findings suggest that IFN-γ-producing NKp46+mucosal NK cell subset is involved in the pathogenesis of Crohn's disease.
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