• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of a biomarker of the epithelial stem cell and analysis of the regenerative and carcinogenic mechanisms of digestive tract

Research Project

Project/Area Number 22790676
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKansai Medical University

Principal Investigator

FUKUI Toshiro  関西医科大学, 医学部, 講師 (60402905)

Research Collaborator KISHIMOTO Masanobu  関西医科大学, 医学部, 大学院生
TKAHASHI Yu  関西医科大学, 医学部, 大学院生
SUZUKI Ryo  関西医科大学, 医学部, 大学院生
OKAZAKI Kazuichi  関西医科大学, 医学部, 教授 (70145126)
MATSUZAKI Koichi  関西医科大学, 医学部, 准教授 (70278638)
UCHIDA Kazushige  関西医科大学, 医学部, 講師 (40411516)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords上部消化管学(食道、胃、十二指腸) / 消化管上皮幹細胞 / 消化管粘膜再生 / 腫瘍 / 癌幹細胞 / 発生・分化 / シグナル伝達 / 上皮幹細胞 / 細菌 / 癌
Research Abstract

We have identified the significant expression of pSmad2/3L-Thr in specific epithelial cells of the murine stomach, small intestine, and colon. We have suggested these cells to be epithelial stem cells in the G0 phase of the cell cycle before active proliferation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis2011

    • Author(s)
      Toshiro Fukui
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 4 Pages: 456-168

    • DOI

      10.1007/s00535-010-0364-8

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis.2011

    • Author(s)
      Toshiro Fukui
    • Journal Title

      Journal of Gastroenterology

      Volume: (in press)

    • NAID

      10029028438

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] pSmad2/3L-Thrの消化管幹細胞マーカーとしての検討とその応用2013

    • Author(s)
      高橋悠
    • Organizer
      第99回日本消化器病学会総会(シンポジウム14「消化器領域における幹細胞研究の進歩」)
    • Place of Presentation
      鹿児島市
    • Related Report
      2012 Final Research Report
  • [Presentation] pSmad2/3L-Thrの消化管幹細胞マーカーとしての検討とその応用2013

    • Author(s)
      高橋悠
    • Organizer
      第99回日本消化器病学会総会( シンポジウム14「消化器領域における幹細胞研究の進歩」)
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overexpression of Smad2/3, phosphorylated at specific linker threonine residues, in the murine model of Dextran Sodium Sulfate-Induced Colitis2012

    • Author(s)
      Masanobu Kishimoto
    • Organizer
      The 6th Korea-Japan IBD Symposium
    • Place of Presentation
      Keio Plaza Hotel Tokyo, Tokyo, Japan
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in oesophagus2012

    • Author(s)
      Yu Takahashi
    • Organizer
      20th United European Gastroenterology Week
    • Place of Presentation
      Amsterdam(オランダ)
    • Related Report
      2012 Final Research Report
  • [Presentation] The Specific Linker Phosphorylation of Smad2/3 Indicates Epithelial Stem Cells in Esophagus2012

    • Author(s)
      Yu Takahashi
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego(アメリカ合衆国)
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化管上皮におけるpSmad2/3L-Thr陽性細胞の検討2012

    • Author(s)
      高橋悠
    • Organizer
      第98回日本消化器病学会総会(シンポジウム2「消化管stemcellの新たな展開」)
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化管上皮におけるpSmad2/3L-Thr陽性細胞の検討2012

    • Author(s)
      高橋悠
    • Organizer
      第98回日本消化器病学会総会( シンポジウム2「消化管stem cellの新たな展開」)
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Specific Linker Phosphorylation of Smad2/3 Indicates Epithelial Stem Cells in Esophagus2012

    • Author(s)
      Yu Takahashi
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in oesophagus2012

    • Author(s)
      Yu Takahashi
    • Organizer
      20th United European Gastroenterology Week
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Annual Research Report
  • [Presentation] The specific linker phosphorylation of Smad2/3 might indicate opithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis2011

    • Author(s)
      Toshiro Fukui
    • Organizer
      GI Research Academy 2011
    • Place of Presentation
      The Westin Miyako Kyoto, Kyoto, Japan
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 消化管上皮細胞におけるリン酸化Smad蛋白発現の検討と消化管幹細胞<ヘリコバクター胃炎モデルマウスについての検討を中心に>2011

    • Author(s)
      福井寿朗
    • Organizer
      第6回Bay Area Gut Club (BAG)
    • Place of Presentation
      ホテルグランヴィア大阪(大阪府)
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in colon; particularly increasing in the regeneration phase of murine model of dextran sulfate sodium-induced colitis

    • Author(s)
      Toshiro Fukui
    • Organizer
      GI Research Academy 2012
    • Place of Presentation
      KEIDANREN KAIKAN, (Tokyo)
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi