Association between genetic and clinical characteristics and tailor made therapy in idiopathic ventricular fibrillation
Project/Area Number |
22790696
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 不整脈 / 心電図 / 遺伝子 / イオンチャネル / リスクファクター |
Research Abstract |
There has been increasing interest in idiopathic ventricular fibrillation, but the clinical characteristics, underlying mechanisms, and genetic background are unclear. Furthermore, the data for risk stratification to prevent sudden death is not enough. We identified clinical characteristics, novel genetic background, and the underlying mechanisms in idiopathic ventricular fibrillation. We also found risk factors for arrhythmia recurrences that are useful for tailor made therapy.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Response to letter regarding article,"electrocardiographic characteristics and scn5a mutations in idiopathic ventricular fibrillation associated with early repolarization"2012
Author(s)
Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M,Aizawa Y, Shimizu W, Makita N
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Journal Title
Circ Arrhythm Electrophysiol
Pages: 60-61
Related Report
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[Journal Article] A connexin40 mutation associated with a malignant variant of progressive familial heart block type i2012
Author(s)
Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M
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Journal Title
Circ Arrhythm Electrophysiol
Volume: 5
Pages: 163-172
NAID
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[Journal Article] The prevalence of early repolarization in wolff-parkinson-white syndrome with a special reference to j waves and the effects of catheter ablation2011
Author(s)
Yagihara N, Sato A, Iijima K, Izumi D, Furushima H, Watanabe H, Irie T, Kaneko Y, Kurabayashi M, Chinushi M, Satou M, Aizawa Y
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Journal Title
Related Report
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[Journal Article] Striking in vivo phenotype of a disease-associated human scn5a mutation producing minimal changes in vitro2011
Author(s)
Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Jr., Roden DM
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Journal Title
Circulation
Volume: 124
Pages: 1001-1011
Related Report
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[Journal Article] Electrocardiographic characteristics and scn5a mutations in idiopathic ventricular fibrillation associated with early repolarization2011
Author(s)
Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
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Journal Title
Circ Arrhythm Electrophysiol
Volume: 4
Pages: 874-881
Related Report
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[Journal Article] Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia2011
Author(s)
van der Werf C, Kannankeril PJ, Sacher F, Krahn AD, Viskin S, Leenhardt A, Shimizu W, Sumitomo N, Fish FA, Bhuiyan ZA, Willems AR, van der Veen MJ, Watanabe H, Laborderie J, Haissaguerre M, Knollmann BC, Wilde AA
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Journal Title
J Am Coll Cardiol
Volume: 57
Pages: 2244-2254
Related Report
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[Journal Article] Analysis of j waves during myocardial ischaemia2011
Author(s)
Sato A, Tanabe Y, Chinushi M, Hayashi Y, Yoshida T, Ito E, Izumi D, Iijima K, Yagihara N, Watanabe H, Furushima H, Aizawa Y
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Journal Title
Related Report
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[Journal Article] Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel2011
Author(s)
Atack TC, Myers Stroud D, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM
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Journal Title
Circ Res
Volume: 109
Pages: 38-46
Related Report
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[Journal Article] Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated with Early Repolarization2011
Author(s)
Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
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Journal Title
Circ Arrhythm Electrophysiol
Volume: 4
Issue: 6
Pages: 874-881
DOI
Related Report
Peer Reviewed
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