| Project/Area Number |
22790825
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | アレキサンダー病 / GFAP / ショウジョウバエ / プロモーター遺伝子 / グリア細胞 / 脳・神経 / 脳神経疾患 / 希少難病 / ショウジョウバエモデル / 神経科学 |
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| Research Abstract |
Alexander disease is a rare neurodegenerative disease caused by the mutations encoding glial fibrillary acidic protein(GFAP). To identify modified factors to clarify functional alteration of glial cells with mutant GFAP, we performed microarray analysis, real-time PCR or GFAP promoter gene analysis using cell models or patient's DNA. These studies indicated αB-crystallin may play an important role in mutant GFAP cells and the alteration of GFAP expression controlled by GFAP promoter gene may modify the clinical course. We also prepared Drosophia model constructed by inducing GFAP gene as a new disease model.
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