Research on new method for evaluating insulin secretion, and association with the genetic factors
| Project/Area Number |
22790862
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
HIROTA Yushi 神戸大学, 医学部附属病院・糖尿病・内分泌内科, 助教 (80566018)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 糖尿病 / 遺伝因子 / インスリン分泌能 / インスリン抵抗性 / 高血糖クランプ / 正常血糖高インスリンクランプ / ディスポジション・インデック / ディスポジション・インデックス |
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| Research Abstract |
Disposition index determined by glucose clamp technique (clamp DI) differed significantly among NGT, IGT and T2DM. Clamp DI was decreased with deterioration in glucose tolerance. Therefore, we consider clamp DI as more sensitive measure of beta cell function. We showed the risk allele of KCNQ1, which is the most important disease susceptibility gene identified by Japanese people, was associated with decrease of clamp DI in IGT.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A Minimally Invasive System for Glucose Area under the Curve Measurement using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with OGTTs in Diabetic and Nondiabetic Subjects2012
Author(s)
Sakaguchi K, Hirota Y, Hashimoto N, Ogawa W, Sato T, Okada S, Hagino K, Asakura Y, Kikkawa Y, Kojima J, Maekawa Y, Nakajima H
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Journal Title
Diabetes Technol Ther
Volume: 14(6)
Pages: 485-491
Related Report
Peer Reviewed
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