Elucidation of the mechanism of iron action against anti-diabetes and search for a new therapeutic target of diabetes研究代表池田康将(IKEDA YASUMASA)
Project/Area Number |
22790864
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | The University of Tokushima |
Principal Investigator |
IKEDA Yasumasa 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60432754)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 鉄 / 肥満 / 糖尿病 / 酸化ストレス |
Research Abstract |
It has been shown that the amount of visceral fat is related to body iron content, and body iron storage is a risk factor of the development of diabetes. We examined the effect of iron deprivation in fat tissue. Iron deprivation contributed to 1) decrease of fat weight and adipocyte size, 2) reduction of macrophage invasion in fat, 3) suppression of oxidative stress and inflammatory cytokine, 4) improvement of Akt-IRS pathway. These results suggest that iron chelation improve the development of adipocyte hypertrophy via suppression of oxidative stress, leading to the amelioration of glucose tolerance.
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice2011
Author(s)
Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, and Tamaki T
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302
Issue: 1
Pages: E77-E86
DOI
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Peer Reviewed
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[Journal Article] Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice2010
Author(s)
Sumitomo-Ueda Y, Aihara K, Ise T, Yoshida S, Ikeda Y, Uemoto R, Yagi S, Iwase T, Ishikawa K, Hirata Y, Akaike M, Sata M, Kato S, Matsumoto T
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Journal Title
Hypertension
Volume: 56
Issue: 3
Pages: 430-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manne2010
Author(s)
Ishizawa K, Izawa-Ishizawa Y, Dorjsuren N, Miki E, Kihira Y, Ikeda Y, Hamano S, Kawazoe K, Minakuchi K, Tomita S, Tsuchiya K and Tamaki T
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Journal Title
Nephrol Dial Transpl
Volume: 25
Issue: 2
Pages: 364-372
DOI
Related Report
Peer Reviewed
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[Presentation] Iron restriction prevents progression of diabetic nephropathy2012
Author(s)
Yasumasa Ikeda, Hideaki Enomoto, Soichiro Tajima, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki.
Organizer
KEYSTONE SYMPOSIA 40th ANNIVERSARY 1972-2012
Place of Presentation
Park & Plaza Hotel, Boston, Massachusetts, USA
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[Presentation] Heparin Cofactor II Promotes Angiogenesis via an AMPK-eNOS Signaling Pathway2011
Author(s)
Yasumasa Ikeda, Ken-ici Aihara, Sumiko Yoshida, Yoshitaka Kihira, Keisuke Ishizawa, Yuki Izawa-Ishizawa, Shuhei Tomita, Masataka Sata, Masashi Akaike, Shigeki Kato, Toshio Matsumoto, Toshiaki Tamaki.
Organizer
High Blood Pressure Research Scientific Sessions 2011 Scientific Sessions. Dolphin Hotel, Orlando
Place of Presentation
Florida
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