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The research of the luekemogenesis in patients with DS-AMKL byusing CGH array

Research Project

Project/Area Number 22790974
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNagoya University

Principal Investigator

HAMA Asahito  名古屋大学, 医学系研究科, 助教 (30566964)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords急性巨核芽球性白血病 / ダウン症候群 / 一過性異常骨髄増殖症 / 染色体異常 / CGHアレイ / SNP アレイ / 小児 / GATA1 / SNPアレイ
Research Abstract

To reveal the mechanism of the development from transient abnormal myelopoiesis (TAM) to acute megakaryoblastic leukemia (DS-AMKL) in children with Down syndrome, we analyzed these subgroups of patients (11 children with DS-AMKL, 12 children with non-DS-AMKL) by SNP array-based karyotyping and sequencing. Somatic gains were found in 7 DS-AMKL patients, while deletions were found in 8 DS-AMKL patients. Somatic gains were found in 7 non-DS-AMKL patients, while deletions were present in 5 patients. Mutational screen found GATA1mutations in 10/11 DS-AMKL, but mutations were rare in non-DS-AMKL (1/12).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Molecular lesions in childhood and adult acute megakaryoblastic leukaemia2012

    • Author(s)
      Hama A, Muramatsu H, Makishima H, Sugimoto Y, Szpurka H, Jasek M, O'Keefe C, Takahashi Y, Sakaguchi H, DOI:saki S, Shimada A, Watanabe N, Kato K, Kiyoi H, Naoe T, Kojima S, Maciejewski JP
    • Journal Title

      Br J Haematol

      Volume: 156 Pages: 316-325

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular lesions in childhood and adult acute megakaryoblastic leukemia2012

    • Author(s)
      Asahito Hama
    • Journal Title

      British Journal of Haematology

      Volume: 156 Pages: 316-325

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gene Alterations in Acute Megakaryoblastic Leukemia (AMKL): a Comparison of AMKL with and without Down Syndrome2010

    • Author(s)
      Hama A
    • Organizer
      52nd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene alterations of acute megakaryoblastic leukemia (AMKL) : a comparison of AMKL with and without Down syndrome2010

    • Author(s)
      濱麻人
    • Organizer
      第52回米国血液学会
    • Place of Presentation
      オーランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene alterations of acute megakaryoblastic leukemia(AMKL) with and without Down syndrome2010

    • Author(s)
      濱 麻人
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene alterations of acute megakaryoblastic leukemia (AMKL) : a comparison of AMKL with and without Down syndrome2010

    • Author(s)
      濱麻人
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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