| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We have found that type 2 inositol trisphosphate receptor, one of intracellular calcium release channels, is expressed specifically in the vascular smooth muscle cells of the pulmonary arteries not of the systemic arteries nor of the bronchi in the lung tissue, and that disruption of the gene of type 2 inositol trisphosphate receptor might worsen monocrotaline pyrrole-induced pulmonary hypertension. Our results suggest that type 2 inositol trisphosphate receptor might have a role for controlling pulmonary vascular tone and negatively regulate exacerbation of pulmonary hypertension.
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