Anti-TNF-alpha antibody attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer

• Project/Area Number: 22791062
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: SAITO Yuki 金沢大学, 医学系, 助教 (90547168)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 虚血再潅流 / 褥瘡 / TNF-α / iNOS / 接着分子 / 1400W / NO / NOS

Research Abstract

In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-TNF-α antibody and 1400W inhibited expression of inducible nitric oxide synthase and cytotoxicity of TNF-α From that reason, I suggest that anti-TNF-α antibody treatment might prevent the pressure ulcers.