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Dose calculation system using in-treatment cone-beam CT for adaptive radiation therapy

Research Project

Project/Area Number 22791176
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

HAGA Akihiro  東京大学, 医学部附属病院, 助教 (30448021)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords強度変調放射線治療 / VMAT / コーンビームCT / Deformable registration / 高精度放射線治療 / 経時的最適化 / Adaptive radiotherapy / 臓器の動き / Deformable Registration / Adaptive Radiotherapy / Adaptive Rdiotherapy
Research Abstract

In this research, I developed a four dimensional(4D) cone-beam CT(CBCT) during course of treatment and during treatment by using linac-mounted diagnostic kV X-ray, which corresponds to time-dependent variation of the irradiated cites. With the 4D CBCT, I established the system to verify a cumulative dose distribution in a patient by introducing non-rigid registration(deformable image registration). Through this study, the method to estimate an irradiation accompanied by CBCT imaging and the image processing automation were developed.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (44 results)

All 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (14 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Single-Arc Volumetric Modulated Arc Therapy Planning for Left Breast Cancer and Regional Nodes2012

    • Author(s)
      A. Sakumi, K. Shiraishi, T. Onoe, K. Yamamoto, A. Haga, et al.
    • Journal Title

      J. Radiat. Res. 2

      Volume: 53(1) Pages: 151-3

    • NAID

      10030023919

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between bladder volume and irradiated dose of small bowel in CT-based planning of intracavitary brachytherapy for cervical cancer2012

    • Author(s)
      H. Yamashita, K Nakagawa, K. Okuma, A. Sakumi, A. Haga, et al.
    • Journal Title

      Jpn. J. Clin. Oncol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between bladder volume and irradiated dose of small bowel in CT-based planning of intracavitary brachytherapy for cervical cancer2012

    • Author(s)
      H.Yamashita, K.Nakagawa, K.Okuma, A.Sakumi, A.Haga, R.Kobayashi, K.Ohtomo
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 42 Issue: 4 Pages: 302-308

    • DOI

      10.1093/jjco/hyr203

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Arc Volumetric Modulated Arc Therapy Planning for Left Breast Cancer and Regional Nodes2012

    • Author(s)
      A.Sakumi, K.Shiraishi, T.Onoe, K.Yamamoto, A.HAGA, K.Yoda, K.Ohtomo, K.Nakagawa
    • Journal Title

      Journal of Radiation Research

      Volume: 53 Issue: 1 Pages: 151-153

    • DOI

      10.1269/jrr.11159

    • NAID

      10030023919

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-treatment 4D cone-beam CT with image-based respiratory phase recognition2012

    • Author(s)
      Kida S, Masutani Y, Yamashita H, Imae T, Matsuura T, Saotome N, Ohtomo K, Nakagawa K, Haga A
    • Journal Title

      Radiological Physics and Technology

      Volume: 25 Issue: 2 Pages: 1-9

    • DOI

      10.1007/s12194-012-0146-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four-dimensional measurement of the displacement of internal fiducial and skin markers during 320-multislice computed tomography scanning of breast cancer2012

    • Author(s)
      Hideomi Yamashita
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 84 Issue: 2 Pages: 331

    • DOI

      10.1016/j.ijrobp.2011.12.030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4D-CBCT reconstruction using MV portal imaging during volumetric modulatedarc therapy2011

    • Author(s)
      S. Kida, et al.
    • Journal Title

      Radiotherapy and Oncology 100

      Pages: 380-385

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 呼気および吸気時CT画像に基づく胸郭運動モデルの構築2011

    • Author(s)
      伊藤広貴、越塚誠一、芳賀昭弘、中川恵一
    • Journal Title

      Medical Imaging Technology

      Volume: Vol.29, No.4 Pages: 208-214

    • NAID

      130001206633

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 320列CT装置を用いた肺定位放射線治療における標的の軌跡解析2011

    • Author(s)
      今江禄一, 芳賀昭弘, 中川恵一, 他
    • Journal Title

      日本放射線技術学会

      Volume: 67(3) Pages: 202-211

    • NAID

      10027963515

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] First In-situ Dose Calculation Report Using In-treatment Kilovoltage Cone-beam CT and In-treatment Linac Parameters during Volumetric Modulated Arc Therapy2011

    • Author(s)
      A. Sakumi, A. Haga, et al.
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Pages: 536-537

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cone Beam Computed Tomography Data Acquisition during VMAT Delivery with Subsequent Respiratory Phase Sorting Based on Projection Image Cross-correlation2011

    • Author(s)
      K. Nakagawa, S. Kida, A. Haga, et al.
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Pages: 112-113

    • NAID

      10027418514

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four-Dimensional Measurement of the Displacement of Internal Fiducial Markers During 320-Multislice Computed Tomography Scanning of Thoracic Esophageal Cancer2011

    • Author(s)
      H. Yamashita, S. Kida, A. Sakumi, A. Haga, et al.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: Vol.79 Pages: 588-595

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Motion Analysis of Target in Stereotactic Radiotherapy of Lung Tumors Using 320-row Multidetector CT2011

    • Author(s)
      今江禄一、芳賀昭弘, ら
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 67 Issue: 3 Pages: 202-211

    • DOI

      10.6009/jjrt.67.202

    • NAID

      10027963515

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼気および吸気時CT画像に基づく胸郭運動モデルの構築2011

    • Author(s)
      伊藤広貴、越塚誠一、芳賀昭弘, ら
    • Journal Title

      Medical Imaging Technology

      Volume: 29 Pages: 208-214

    • NAID

      130001206633

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4D-CBCT reconstruction using MV portal imaging during volumetric modulated arc therapy2011

    • Author(s)
      S.Kida, et al., Corresponding Author; A.Haga
    • Journal Title

      Radiotherapy and Oncology

      Volume: 100 Issue: 3 Pages: 380-385

    • DOI

      10.1016/j.radonc.2011.08.047

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FOUR-DIMENSIONAL MEASUREMENT OF THE DISPLACEMENT OF INTERNAL FIDUCIAL MARKERS DURING 320-MULTISLICE COMPUTED TOMOGRAPHY SCANNING OF THORACIC ESOPHAGEAL CANCER2011

    • Author(s)
      H.Yamashita, S.Kida, A.Sakumi, A.Haga, et al.
    • Journal Title

      Int.J.Radiation Oncology Biol.Phys.

      Volume: 79 Pages: 588-595

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prescreening based on the presence of CT-scan abnormalities and biomarkers(KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy2010

    • Author(s)
      H. Yamashita, K. S. Shibata, A. Okuma, A. Haga, et al.
    • Journal Title

      Radiation and Oncology 2010 May 9

      Volume: 5(1) Pages: 32-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療のための粒子法シミュレーションに基づく胸部Simulation-based4DCTの構成2010

    • Author(s)
      伊藤広貴, 越塚誠一, 志野亮作, 芳賀昭弘, 他
    • Journal Title

      Medical Imaging Technology

      Volume: Vol.28, No.4 Pages: 229-236

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胸式呼吸と心拍動による肺野変形のAxial面における粒子法シミュレーション2010

    • Author(s)
      伊藤広貴, 越塚誠一, 中川恵一, 芳賀昭弘
    • Journal Title

      日本シミュレーション学会論文誌

      Volume: Vol.2, No.3 Pages: 93-10

    • NAID

      130004544033

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patient setup error and day-to-day esophageal motion error analyzed by cone-beam computed tomography in radiation therapy2010

    • Author(s)
      H. Yamashita, A. Haga, et al.
    • Journal Title

      Acta Oncologica

      Volume: 49 Pages: 485-409

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patient setup error and day-to-day esophagealmotion error analyzed by cone-beam computedtomography in radiation therapy2010

    • Author(s)
      H.Yamashita, A.Haga, et al.
    • Journal Title

      Acta Oncologica

      Volume: 49 Pages: 485-490

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-treatment 4D cone-beam CT withimage-based respiratory phase recognition

    • Author(s)
      S. Kida, et al.
    • Journal Title

      Radiological Physics and Technology, to be published

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four-dimensional measurement of thedisplacement of internal fiducial and skinmarkers during 320-multislice computed tomography scanning of breast cancer

    • Author(s)
      H. Yamashita, K. Ohkuma, K. Tada, K. Shiraishi, W. Takahashi, S. Shibata, A. Sakumi, N. Saotome, A. Haga, et al.
    • Journal Title

      International Journal of Radiation Oncology, Biology, to be published

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Four Dimensional Cone-Beam CT and VMAT2012

    • Author(s)
      A. Haga
    • Organizer
      Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-02-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Four Dimensional Cone-Beam CT and VMAT2012

    • Author(s)
      芳賀昭弘
    • Organizer
      Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Kyoto(招待講演)
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lung SBRT using VMAT and in-treatment KV & MV cone beam CT imaging2012

    • Author(s)
      A. Haga.
    • Organizer
      Symposium for Stereotactic Body Radiation Therapy(SBRT) for Liver, Lung & SpineTumour
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2012-01-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Lung SBRT using VMAT and in-treatment KV & MV cone beam CT imaging2012

    • Author(s)
      芳賀昭弘
    • Organizer
      Symposium for Stereotactic Body Radiation Therapy (SBRT) for Liver, Lung & Spine Tumour
    • Place of Presentation
      New Delhi, India(招待講演)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel verification method using in-treatment 4D CBCT2011

    • Author(s)
      A. Haga, S. Kida, N. Saotome, et al.
    • Organizer
      The 6th JKMP and the 11th AOCMP Meeting
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel verification method using in-treatment 4D CBCT2011

    • Author(s)
      芳賀昭弘
    • Organizer
      The 6th JKMP and the 11th AOCMP Meeting
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 強度変調放射線治療の品質管理2011

    • Author(s)
      芳賀昭弘
    • Organizer
      日本医学物理学会品質管理講習会
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Quality Assurance of Intensity-Modulated Radiation Therapy2011

    • Author(s)
      芳賀昭弘
    • Organizer
      日本医学物理学会;放射線品質管理講習会
    • Place of Presentation
      九州大学(招待講演)
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] VMAT with MONACO2011

    • Author(s)
      A. Haga, et al.
    • Organizer
      the novel TPS : Present status and future application. ESTRO2011
    • Place of Presentation
      London, England
    • Year and Date
      2011-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線治療の高度化が臨床に与える影響医学物理士から2010

    • Author(s)
      芳賀昭弘
    • Organizer
      日本放射線腫瘍学会
    • Place of Presentation
      東京ベイ舞浜ホテル
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線治療の高精度化が臨床に与える影響2010

    • Author(s)
      芳賀昭弘
    • Organizer
      Joint Symposium in JASTRO meeting
    • Place of Presentation
      舞浜,千葉
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 最新X線治療~経時的最適化放射線治療2010

    • Author(s)
      芳賀昭弘
    • Organizer
      放射線によるがん治療・診断の最前線を探る(シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2010-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Tracking Volume Change during IMRT treatment using non-rigid registration2010

    • Author(s)
      A. Haga, et al.
    • Organizer
      ESTRO2010
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of treatment planning systems in Elekta Volumetric Modulated Arc Therapy(Elekta VMAT)-prostate cancer study2010

    • Author(s)
      A. Haga, et al.
    • Organizer
      AAPM2010
    • Place of Presentation
      Philadelphia, America
    • Year and Date
      2010-08-01
    • Related Report
      2011 Final Research Report
  • [Book] 病院と患者のための放射線治療2012

    • Author(s)
      中川恵一、芳賀昭弘, 他
    • Publisher
      産業科学株式会社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 放射線治療最前線2011

    • Author(s)
      中川恵一、芳賀昭弘, 他多数
    • Publisher
      インナービジョン
    • Related Report
      2011 Final Research Report
  • [Book] 放射線治療と医学物理の理工学2011

    • Author(s)
      芳賀昭弘, 他多数
    • Total Pages
      300
    • Publisher
      養賢堂
    • Related Report
      2010 Annual Research Report
  • [Book] 放射線治療と医学物理の理工学

    • Author(s)
      芳賀昭弘, 他多数
    • Publisher
      養賢堂
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo-rad.jp/works/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo-rad.jp/works/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo-rad.jp/works/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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