Over-expression of the RD RNA binding protein is associated with portal vein invasion in hepatocellular carcinoma.

Research Project

Project/Area Number	22791285
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	IIDA Michihisa 山口大学, 医学部附属病院, 助教 (50554797)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	肝細胞癌門脈浸潤 / 肝細胞癌 / 門脈浸潤 / RDBP
Research Abstract	Both mRNA and protein levels of RDBP were significantly higher in HCC than in non-HCC liver tissue, and that these levels were also significantly higher in HCC with PVI than in HCC without PVI. Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC within two years of surgery. Knockdown of RDBP protein significantly inhibited the proliferation and invasion of cells invitro. These data demonstrate that RDBP is related to the metastatic potential of HCC, suggesting a possible candidate for prevention of HCC cell metastasis.

Report

(3 results)