| Project/Area Number |
22791362
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
INOUE Hiroto 大阪医科大学, 医学部, 非常勤医師 (00570532)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん幹細胞 / ABCG2 / ポルフィリン / 光線力学療法 / 5アミノレブリン酸 / 悪性脳腫瘍 / グリオーマ / ゲフィチニブ / 5-アミノレブリン酸 / Gefitinib |
|---|
| Research Abstract |
As ABCG2 transporter, a main cause of chemo-resistance in cancer stem cells, also transports porphyrin to extracellular space, ABCG2 may be an effective target for photodynamic therapy. In this study, we proofed that gefitinib, a clinical available ABCG2 inhibitor, reduced extra-cellular transportation of porphyrin and increase intra-cellular concentration of porphyrin, consequently, enhanced the treatment efficacy of photodynamic therapy using 5-aminolevulinic acid.
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