Linkage between receptor for advanced glycation end-product
| Project/Area Number |
22791383
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
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|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
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|---|
| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 2型糖尿病 / 椎体骨折 / 骨質 / 骨粗鬆症 / PTH / スクレロスチン / 低骨代謝回転 / 動脈硬化 / 骨血管連関 |
|---|
| Research Abstract |
T2DM patients have an increased fracture risk which is not reflected by bone mineral density, suggesting that they had poor bone quality. The results of our research revealed that decreased bone formation and elevated sclerostin were related with bone quality. In addition, abdominal aortic calcification was also associated with vertebral fracture due to poor bone quality. These findings suggest that mechanisms of deteriorating bone quality may be attributed to bone fragility and vascular calcification.
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Report
(3 results)
Research Products
(111 results)
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[Presentation] 超音波踵骨骨密度測定の2型糖尿病における椎体骨折予知能の検討2010
Author(s)
山口徹、山本昌弘, 金沢一平, 山内美香, 栗岡聡一, 矢野彰三, 田中延子, 新田江里, 福間麻子, 宇野誓子, 庄野智子, 杉本利嗣
Organizer
第53回日本糖尿病学会学術総会
Place of Presentation
岡山コンベンションセンター(岡山)
Related Report
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