| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
It has been reported that less than 50% neuropathic pain patients satisfactorily treated with drugs. It is possible that this low efficacy of drugs on neuropathic pain might be due to the prescription of drugs regardless of the origin of pain. We compared the efficacy of orally administered morphine, pregabalin, gabapentin and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition(TNT) model. In the TNT model, the tibial nerve is transected and the tibial nerve stump is transpositioned to the lateral aspect of the hindlimb. After TNT injury, mechanical allodynia and neuroma pain are observed. Morphine, pregabalin, gabapentin and duloxetine were administered orally and were examined the anti-allodynic and anti-neuroma pain effects. Morphine, pregabalin, gabapentin and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner. Morphine, but not pregabalin, gabapentin and duloxetine, attenuated the neuroma pain. Morphine was less potent in neuroma pain than in mechanical allodynia. In the two drugs combination studies(morphine+pregabalin, morphine+duloxetine and pregabalin+duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain. This data indicated that the potency of morphine and the efficacy of
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