Novel pathological parameters in regional lymph nodes of urothelial carcinoma focused on "Seed and Soil" theory
| Project/Area Number |
22791462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ABE Takashige 北海道大学, 北海道大学病院, 助教 (10399842)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 尿路上皮癌 / 微小リンパ節転移 / 所属リンパ節 / リンパ管新生 / 尿路上皮がん |
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| Research Abstract |
Study 1 : Fifty-one patients treated by nephroureterectomy were included. All had lymph nodes(LNs) and all LNs were negative on hematoxylin and eosin staining. We re-evaluated the presence of micrometastasis in LNs specimens by anti-cytokeratin immunohistochemistory. Immunohistochemistry identified micrometastases in 7(14%) of 51 patients. Study 2 : We prospectively evaluated the presence of micrometastasis in LNs in patients undergoing radical cystectomy or nephroureterectomy. Micrometastasis was detected in 9%(2/22) of patients undergoing radical cystectomy. Study 3 : We evaluated the association between the expression of VEGFC mRNA, VEGFD mRNA, or VEGF3R mRNA and pathological characteristic in primary tumors. We subsequently evaluated the lymph vascular density(LVD) in marginal zone of regional lymph nodes. The expression of VEGFC mRNA was higher in> pT2 disease than<pT1 disease. LVD was higher in patients with node metastasis than patients without it. In addition, the accumulation of lymphatic vessels was observed in half of the cases without node metastases.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Impact of diagnostic ureteroscopy on intravesical recurrence and survival in patients with urothelial carcinoma of the upper urinary tract.2010
Author(s)
Ishikawa S, Abe T, Shinohara N, Harabayashi T, Sazawa A, Maruyama S, Kubota K, Matsuno Y, Osawa T, Shinno Y, Kumagai A, Togashi M, Matsuda H, Mori T, Nonomura K.
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Journal Title
Journal of Urology
Volume: 184(3)
Pages: 883-7
Related Report
Peer Reviewed
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[Journal Article] Role of lymph node dissection in the treatment of urothelial carcinoma of the upper urinary tract : Multi-institutional relapse analysis and immunohistochemical re-evaluation of negative lumph nodes.2010
Author(s)
Abe T, Shinohara N, Muranaka M, Sazawa A, Maruyama S, Osawa T, Harabayashi T, Kubota K, Matsuno Y, Shibata T, Toyoda Y, Shinno Y, Minami K, Sakashita S, Kumagai A, Takada N, Togashi M, Sano H, Mori T, Nonomura K.
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Journal Title
European Journal of Surgical Oncology
Volume: 36
Pages: 1085-1091
Related Report
Peer Reviewed
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