The mechanism of preseasonal prophylactic treatment with antihistamines on pollinosis.

• Project/Area Number: 22791607
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokushima
• Principal Investigator: KITAMURA Yoshiaki 徳島大学, 病院, 講師 (60380028)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 花粉症 / 初期療法 / 遺伝子発現 / ヒスタミンH1受容体

Research Abstract

Preseasonal prophylactic treatment with antihistamines is more effective than on-seasonal administration to patients with pollinosis in reducing nasal symptoms during the peak pollen period by suppressing histamine H1 receptor gene expression in the nasal mucosa.

Research Products

• [Journal Article] 初期療法はなぜ有効なのか? (2012)
  • Author(s): 北村嘉章、水口博之、福井裕行、武田憲昭
  • Journal Title: JOHNS Volume: vol.28、No.1 Pages: 55-58
• [Journal Article] ヒスタミンH1受容体遺伝子発現の亢進メカニズムと花粉症初期療法の分子機構 (2012)
  • Author(s): 北村嘉章、水口博之、福井裕行、武田憲昭
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57 Pages: 45-51
• [Journal Article] Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis (2012)
  • Author(s): Kitamura Y, et al
  • Journal Title: Acta Oto-Laryngologica Volume: 132 Pages: 434-438
  • Peer Reviewed
• [Journal Article] スギ花粉症に対する初期療法 (2011)
  • Author(s): 北村嘉章、水口博之、福井裕行、武田憲昭
  • Journal Title: 小児科 Volume: vol.52、No.6 Pages: 853-858
  • NAID: 130007776099
• [Journal Article] preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis (2010)
  • Author(s): H. Mizuguchi, Y. Kitamura, et al.
  • Journal Title: Methods and Findings in Experimental and Clinical Pharmacol ogy Volume: 32 Issue: 10 Pages: 745-748
  • DOI: 10.1358/mf.2010.32.10.1533687
  • Peer Reviewed
• [Journal Article] preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis (2010)
  • Author(s): H.Mizuguchi, et al.
  • Journal Title: Methods and Findings in Experimental and Clinical Pharmacology Volume: 32 Pages: 745-748
  • Peer Reviewed
• [Presentation] スギ花粉症に対する鼻噴霧ステロイド薬のH1受容体遺伝子発現への効果 (2012)
  • Author(s): 北村嘉章
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 琵琶湖ホテル(滋賀県)
  • Year and Date: 2012-02-16
• [Presentation] ヒスタミンH1受容体拮抗薬を用いたスギ花粉症初期療法におけるH1受容体とサイトカイン遺伝子発現の検討 (2011)
  • Author(s): 北村嘉章
  • Organizer: 第50回日本鼻科学会総会ならびに学術講演会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2011-12-01
• [Presentation] ヒスタミンH1受容体拮抗薬を用いたスギ花粉症初期療法におけるH1受容体遺伝子発現の検討 (2011)
  • Author(s): 北村嘉章
  • Organizer: 第30回国際鼻科感染アレルギーシンポジウム
  • Place of Presentation: ANAインターコンチネンタル東京(東京都)
  • Year and Date: 2011-09-20
• [Presentation] The effect of preseasonal prophylactic treatment with antihistamines on nasal symptoms and histamine H1 receptor expression in the nasal mucosa (2011)
  • Author(s): Yoshiaki Kitamura
  • Organizer: 30th International Symposium on Infection and Allergy of the Nose
  • Place of Presentation: ANA InterContinental hotel Tokyo
  • Year and Date: 2011-09-20
• [Presentation] ヒスタミンH1受容体遺伝子発現の亢進メカニズムと花粉症初期療法の分子機構 (2010)
  • Author(s): 北村嘉章
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] ヒスタミンH1受容体遺伝子発現の亢進メカニズムと花粉症初期療法の分岐機構 (2010)
  • Author(s): 北村嘉章
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] スギ花粉症における初期療法の作用機序の検討 (2010)
  • Author(s): 北村嘉章
  • Organizer: 第49回日本鼻科学会総会ならびに学術講演会
  • Place of Presentation: ネッサンスサッポロホテル(北海道)
  • Year and Date: 2010-08-26