Regulation mechanism of antigen recognition by controlling the interaction of dendritic cells and mucosal cells in the epithelium

Research Project

Project/Area Number	22791615
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Sapporo Medical University
Principal Investigator	KUROSE Makoto 札幌医科大学, 医学部, 助教 (60404696)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	特異的免疫療法 / 樹状細胞 / テロメラーゼ遺伝子導入培養ヒト粘膜上皮細胞 / 特異的免疫反応
Research Abstract	Nasopharynx and nasal mucosa are located at the forefront of the host defense against foreign pathogens, which plays an important role in acquired immunity and innate immunity. To elucidate the immune system of allergy infection, we analyzed the mechanism of epithelial barrier function and antigen presentation in the nasal epithelium of human nasopharyngeal epithelium. In addition, we made a research on the interaction of dendritic cells and mucosal epithelium.

Report

(3 results)