Meibomian Gland(MG) and Ocular Surface Alterations in Sod1 knock-out(KO) Mice : A Novel Model for Age Related Dry Eye Disease.

• Project/Area Number: 22791694
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: IBRAHIM Osama mohamed aly 慶應義塾大学, 医学部, 研究員(非常勤) (90528340)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: マイボーム腺 / ドライアイ / 酸化ストレス

Research Abstract

We investigated the alterations of the MG in the SOD1KO mice. SOD1KO caused inflammation, apoptosis, dry eye and corneal damage. The SOD1-KO mouse appears to be a promising model for the study of age related meibomian gland alterations.

Research Products

• [Presentation] Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease (2011)
  • Author(s): Ibrahim Osama
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)
  • Place of Presentation: Lauderdale, USA
  • Year and Date: 2011-05-05
• [Presentation] Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease (2011)
  • Author(s): Osama Ibrahim
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: フロリダ州フォートローダーデール(米国)
  • Year and Date: 2011-05-05
• [Presentation] Meibomian Gland and Ocular Surface Alterations in Sod1 knock-out Mice : A Novel Model for Age Related Dry Eye Disease. (2010)
  • Author(s): Osama Ibrahim
  • Organizer: ARVO
  • Place of Presentation: U.S.A., Fort Lauderdale