• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Immunological approach to investigate the mechanism of treatment resistant endogenous uveitis and to establish a new treatment

Research Project

Project/Area Number 22791696
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTokyo Medical University

Principal Investigator

OKUNUKI Yoko  東京医科大学, 医学部, 助教 (40459508)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsVogt-小柳-原田病 / IL-17 / トランスレーショナルリサーチ / 副腎皮質ステロイド / 末梢血リンパ球(PBMC) / 免疫学
Research Abstract

In Vogt-Koyanagi-Harada disease, patients with high IL-17 production from concanavalin A stimulated PBMC were older, took longer time to improve visual acuity, and needed greater amount of corticosteroid than patients with low IL-17.Prognosis of the patients with high IL-17 production with PBMC was suggested to be worse than the patients with low IL-17.IL-17 production from PBMC can be a disease activity marker in Vogt-Koyanagi-Harada disease.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results)

  • [Journal Article] Costimulatory molecule expression on human uveal melanoma cells : functional analysis of CD40 and B7-H12012

    • Author(s)
      Ma J, Usui Y, Kezuka T, Okunuki Y, Zhang L, An X, Mizota, Goto H
    • Journal Title

      Experimental Eye Research

      Volume: 96 Issue: 1 Pages: 98-106

    • DOI

      10.1016/j.exer.2011.12.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion2011

    • Author(s)
      Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y
    • Journal Title

      American Journal of Ophthalmology

      Volume: 151 Pages: 610-616

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four cases of bilateral acute retinal necrosis with a long interval after the initial onset2011

    • Author(s)
      Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H
    • Journal Title

      British Journal of Ophthalmology

      Volume: 95 Pages: 1251-1254

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy2011

    • Author(s)
      Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H
    • Journal Title

      Retina

      Volume: 31 Pages: 1951-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy2011

    • Author(s)
      Okunuki Y, Wakabayashi Y, Usui Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H
    • Journal Title

      Retina

      Volume: 31 Issue: 9 Pages: 1951-1957

    • DOI

      10.1097/iae.0b013e31820d3cee

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion.2011

    • Author(s)
      Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 151 Pages: 610-616

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four cases of bilateral acute retinal necrosis with a long interval after the initial onset.2011

    • Author(s)
      Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H.
    • Journal Title

      British Journal of Ophthalmology

      Volume: (ePub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy2010

    • Author(s)
      Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, Iwasaki T
    • Journal Title

      Retina

      Volume: 30 Pages: 339-44

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Vogt-小柳-原田病の発症時年齢および性別と臨床像に関する検討2012

    • Author(s)
      奥貫陽子、臼井嘉彦、毛塚剛司、後藤浩
    • Organizer
      116回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytokine analysis and visual prognosis of Vogt-Koyanagi-Harada disease2011

    • Author(s)
      Yoko Okunuki
    • Organizer
      The 11th international ocular inflammation society congress and international assembly of ocular inflammation society
    • Place of Presentation
      インド
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytokine analysis and visual prognosis of Vogt-Koyanagi-Harada disease2011

    • Author(s)
      奥貫陽子
    • Organizer
      The 11^<th> international ocular inflammation society congress and international assembly of ocular inflammation society
    • Place of Presentation
      インド、ゴア
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cytokine analysis to estimate the disease activity2010

    • Author(s)
      Yoko Okunuki, Yoshihiko Usui, Takeshi Kezuka, Masaru Takeuchi, Hiroshi Goto
    • Organizer
      Vogt-Koyanagi-Harada disease patients ARVO2010
    • Place of Presentation
      フロリダ
    • Related Report
      2011 Final Research Report
  • [Presentation] Vogt-小柳-原田病患者の末梢血単核球IL-17産生とステロイド治療に対する反応の検討2010

    • Author(s)
      奥貫陽子、臼井嘉彦、毛塚剛司、竹内大、後藤浩
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Cytokine analysis to estimate the disease activity in Vogt-Koyanagi-Harada disease patients2010

    • Author(s)
      Yoko Okunuki, Yoshihiko Usui, Takeshi Kezuka, Masaru Takeuchi, Hiroshi Goto
    • Organizer
      ARVO 2010
    • Place of Presentation
      アメリカ、フロリダ州
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi