• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass

Research Project

Project/Area Number 22791771
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionNagasaki University

Principal Investigator

MORIISHI Takeshi  長崎大学, 大学院・医歯薬学総合研究科, 技術職員 (20380983)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords骨芽細胞 / アポトーシス / Bcl-XL / 骨形成
Research Abstract

In the present study, we generated transgenic mice with osteoblasts that express anti-apoptotic BCL-X_L. In BCL-X_L transgenic mice, bone volume was increased at 10 weeks of age and recognized maintenance of the bone volume at aging mice. In the recent aging society, bone volume decrease by the osteoporosis becomes the big social problem, therefore Bcl-X_L may become the target for the osteoporosis treatment in the future.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis2012

    • Author(s)
      Mizuhashi K, Kanamoto T, Ito M, Moriishi T, Muranishi Y, Omori Y, Terada K, Komori T, Furukawa T.
    • Journal Title

      Dev Growth Differ

    • NAID

      10031136918

    • Related Report
      2011 Final Research Report
  • [Journal Article] SP7 inhibits osteoblast differentiation at a late stage in mice2012

    • Author(s)
      Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T.
    • Journal Title

      PLoS One

      Volume: 7(3)

    • NAID

      120006985432

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis2012

    • Author(s)
      Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T.
    • Journal Title

      Bone

      Volume: 50(1) Pages: 409-19

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis2012

    • Author(s)
      Mizuhashi K
    • Journal Title

      Development, growth and differentiation

      Volume: 54 Issue: 4 Pages: 474-480

    • DOI

      10.1111/j.1440-169x.2012.01333.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis2011

    • Author(s)
      Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T.
    • Journal Title

      PLoS One

      Volume: 6(11)

    • NAID

      120006985216

    • Related Report
      2011 Final Research Report
  • [Journal Article] Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects2011

    • Author(s)
      Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T.
    • Journal Title

      Bone

      Volume: 49(4) Pages: 673-82

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates2011

    • Author(s)
      Cao L, Moriishi T, Miyazaki T, Iimura T, Hamagaki M, Nakane A, Tamamura Y, Komori T, Yamaguchi A.
    • Journal Title

      J Bone Miner Metab

      Volume: 29(6) Pages: 662-70

    • NAID

      10030895041

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis2011

    • Author(s)
      Moriishi T, et al
    • Journal Title

      PLoS One

      Volume: 6(11)

    • NAID

      120006985216

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural analysis of osteoblasts, osteocytes and odontoblasts in Runx2 transgenic mice.2010

    • Author(s)
      Miyazaki, T, Moriishi, T, Izumi, S, Baba, T, Komori, T
    • Journal Title

      J Electr Microsc Technol Med Biol.

      Volume: 23(2) Pages: 50-50

    • Related Report
      2010 Annual Research Report
  • [Presentation] 2はマウス椎間板の発達維持に必須である2011

    • Organizer
      日本分子生物学会年会プログラム・要旨集
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨芽細胞分化における抗アポトーシス分子Bcl-2の役割2010

    • Organizer
      第28回日本骨代謝学会学術集会学術集会プログラム抄録集
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨芽細胞分化における抗アポトーシス分子Bc1-2の役割2010

    • Author(s)
      森石武史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京都新宿区
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi