| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Non-steroidal anti-inflammatory drugs(NSAIDs) have regulatory effect on bone remodeling. The efficacy of NSAIDs on bone remodeling is controversial. In clinics, NSAIDs progress bone repair as their inhibitory effect of inflammatory factors ; in contrast, NSAIDs delay bone fracture healing in animal models. The aim of this study was to elucidate the mechanism of NSAIDs on osteoclast differentiation and bone resorptive activity.
Cyclloxygenase(COX)-1 and-2 transcripts were appeared in early stage of osteoclast differentiation(day3). COX-2 increased on mature osteoclasts and lipopolysaccharide stimulated inflammatory mature osteoclasts. Level of COX-2 transcript has efficacy on extracellular signal-regulated kinase appearance. These results showed that COX-1 and-2 involved in osteoclasts have regulatory effect on osteoclasts differentiation and bone resorptive activity.
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