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The mechanism of non-steroidal anti-inflammatory drugs on osteoclast differentiation and activation.

Research Project

Project/Area Number 22791800
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

KARAKAWA Akiko  昭和大学, 歯学部, 助教 (70552280)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯科薬理学 / 破骨細胞 / NSAIDs / COX / 歯学 / osteoclast / cyclooxygenase
Research Abstract

Non-steroidal anti-inflammatory drugs(NSAIDs) have regulatory effect on bone remodeling. The efficacy of NSAIDs on bone remodeling is controversial. In clinics, NSAIDs progress bone repair as their inhibitory effect of inflammatory factors ; in contrast, NSAIDs delay bone fracture healing in animal models. The aim of this study was to elucidate the mechanism of NSAIDs on osteoclast differentiation and bone resorptive activity.
Cyclloxygenase(COX)-1 and-2 transcripts were appeared in early stage of osteoclast differentiation(day3). COX-2 increased on mature osteoclasts and lipopolysaccharide stimulated inflammatory mature osteoclasts. Level of COX-2 transcript has efficacy on extracellular signal-regulated kinase appearance. These results showed that COX-1 and-2 involved in osteoclasts have regulatory effect on osteoclasts differentiation and bone resorptive activity.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Calcium flux during growth in sham-operated and ovariectomized rats2011

    • Author(s)
      Morohashi T, Karakawa A, Sakai N, Yamada S
    • Journal Title

      Dent Med Res

      Volume: 31 Pages: 1-6

    • NAID

      10027973457

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tetracycline hydrochloride on measurements with the laser fluorescence device DIAGNOdent : in vitro and in vivo studies2011

    • Author(s)
      Nagaoka E, Morohashi T, Kinoshita J, Karakawa A, Sakai N, Yamada S, Inoue M
    • Journal Title

      Lasers Med Sci

      Volume: 27 Pages: 365-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tetracycline hydrochloride on measurements with the laser fluorescence device DIAGNOdent : in vitro and in vivo studies.2011

    • Author(s)
      Nagaoka E, Morohashi T, Kinoshita J, Karakawa A, Sakai N, Yamada S, Inoue M.
    • Journal Title

      Lasers in Medical Science

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium flux during growth in sham-operated and ovariectomized rats.2011

    • Author(s)
      Tomio MOROHASHI, Akiko KARAKAWA, Nobuhiro SAKAI, Shoji YAMADA
    • Journal Title

      Dental Medicine Research

      Volume: 31 Pages: 1-6

    • NAID

      10027973457

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] TLR2アゴニストであるPam3CSK4による破骨細胞形成とラット上顎口蓋骨骨吸収作用について2011

    • Author(s)
      矢野亜希子, 鈴木恵子, 諸橋富夫, 唐川亜希子, 山本松男, 山田庄司
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-27
    • Related Report
      2011 Final Research Report
  • [Presentation] TLR2アゴニストであるPam3CSK4による破骨細胞形成とラット上顎口蓋骨骨吸収作用について2011

    • Author(s)
      矢野亜希子, 鈴木恵子, 諸橋富夫, 唐川亜希子, 山本松男, 山田庄司
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-07-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pam3CSK4, a TLR2 Agonist, Induces in vitro Osteoclastogenesis RANKL Independently and Resorbs Alveolar Bone in Rats2011

    • Author(s)
      Yano A, Suzuki K, Morohashi T, Arimoto T, Karakawa A, Sakai N, Igarashi T, Yamamoto M, Yamada S
    • Organizer
      第31回昭和歯学会総会
    • Place of Presentation
      昭和大学
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs alveolar bone in rats2011

    • Author(s)
      Yano A, Suzuki K, Morohashi T, Arimoto T, Karakawa A, Igarashi T, Shinoda H, Yamamoto M, Yamada S
    • Organizer
      ASBMR 2011 Annual Meeting
    • Place of Presentation
      アメリカ合衆国
    • Related Report
      2011 Final Research Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs alveolar bone in rats2011

    • Author(s)
      Akiko Yano, Keiko Suzuki, Tomio Morohashi, Takafumi Arimoto, Akiko Karakawa, Takeshi Igarashi, Hisashi Shinoda, Matsuo Yamamoto, Shoji Yamada
    • Organizer
      ASBMR 2011 Annual Meeting
    • Place of Presentation
      アメリカ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of tetracycline hydrochloride on measurements with the laser fluorescence device DIAGNOdent : in vitro and in vivo studies2010

    • Author(s)
      Nagaoka E, Morohashi T, Kinoshita J, Karakawa A, Sakai N, Yamada S, Inoue M.
    • Organizer
      第30回昭和歯学会例会
    • Place of Presentation
      昭和大学
    • Year and Date
      2010-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of tetracycline hydrochloride on measurements with the laser fluorescence device DIAGNOdent : in vitro and in vivo studies.2010

    • Author(s)
      E.Nagaoka, T.Morohashi, J.Kinoshita, A.Karakawa, N.Sakai, S.Yamada, M.Inoue
    • Organizer
      第30回昭和歯学会例会
    • Place of Presentation
      昭和大学
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-steroidal Anti-inflammatory Drugs Inhibit Osteoclast Activation by Inhibiting Nuclear Translocation of NFκB.2010

    • Author(s)
      A.Karakawa, H.Amano, K.Suzuki, S.Yamada
    • Organizer
      ASBMR 2010 Annual Meeting
    • Place of Presentation
      カナダ(トロント)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-steroidal Anti-inflammatory Drugs Inhibit Osteoclast Activation by Inhibiting Nuclear Translocation of NF k appa B2010

    • Author(s)
      Karakawa A, Amano H, Suzuki K, and Yamada S
    • Organizer
      ASBMR 2010 Annual Meeting
    • Place of Presentation
      カナダ
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ昭和大学研究成果データベース

    • URL

      https://rdb.showa-u.ac.jp/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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