Evidence construction of a new titanium material concept, and research of the recovery method

• Project/Area Number: 22791908
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: HORI Norio 神奈川歯科大学, 歯学部, 非常勤講師 (20386832)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: チタン / 表面特性 / インプラント / 細胞接着能 / タンパク吸着能 / バイオロジカルエイジング / バイオマテリアル / インプラント-骨接触率 / 生体材料 / 表面性状 / エイジング / 表面加工 / オッセオインテグレーション

Research Abstract

Possible changes in biological potential of titanium(Ti) over time have never been addressed, with a presumption that titanium surfaces are stable in biological property, particularly osseointegration capability. The purpose of this research was to test a hypothesis that protein adsorption capacity and cell attractiveness of Ti, which are critical to the process of osseointegration, changes over time before its use. Degrading trend of protein adsorption capacity and osteoblast attractiveness of Ti surfaces during 4 weeks of storage after processing was remarkable. We postulate that immediate action needs to be taken to explore this phenomenon for possible substantial commercial, scientific and research impacts in the field.

Research Products

• [Journal Article] Effects of UV photofunctionalization on the nanotopography enhanced initial bioactivity of titanium (2011)
  • Author(s): 堀紀雄
  • Journal Title: Acta Biomaterialia Volume: 7(10) Pages: 3679-3691
  • Peer Reviewed
• [Journal Article] Selective cell affinity of biomimetic micro-nano-hybrid structured TiO(2) overcomes the biological dilemma of osteoblasts (2010)
  • Author(s): Hori N, Iwasa F, Ueno T, Takeuchi K, Tsukimura N, Yamada M, Hattori M, Yamamoto A, Ogawa T.
  • Journal Title: Dental Materials Volume: 26 Pages: 275-287
  • Peer Reviewed
• [Journal Article] UV treatment restores age-related degradation of Ti bioactivity and creates more bioactive surface than the fresh surface (2010)
  • Author(s): Hori N, Ueno T, Suzuki T, Iwasa F, Yamada M, Att W, Okada S, Ohno A, Aita H, Kimoto K, Ogawa T.
  • Journal Title: Int J Oral Maxillofac Implant Volume: 25 Pages: 49-62
  • Peer Reviewed
• [Journal Article] Electrostatic control of protein adsorption on UV-photofunctionalized titanium. (2010)
  • Author(s): 堀紀雄
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 4175-4180
  • Peer Reviewed
• [Journal Article] Effect of ultraviolet photoactivation of titanium on osseointegration in a rat model. (2010)
  • Author(s): 堀紀雄
  • Journal Title: Int J Oral Maxillofac Implants Volume: 25 Pages: 287-294
  • Peer Reviewed
• [Journal Article] Enhancement of osteoblast adhesion to UV-photofunctionalized titanium via an electrostatic mechanism. (2010)
  • Author(s): 堀紀雄
  • Journal Title: Biomaterials Volume: 31 Pages: 2717-2727
  • Peer Reviewed
• [Journal Article] Selective cell affinity of biomimetic micro-nano-hybrid structured TiO2 overcomes the biological dilemma of osteoblasts. (2010)
  • Author(s): 堀紀雄
  • Journal Title: Dental Materials Volume: 26 Pages: 275-287
  • Peer Reviewed
• [Presentation] ハイドロキシアパタイトと二酸化チタンによる二重薄膜生成技術を応用したチタン表面改質の検討 (2010)
  • Author(s): 桑原淳之, 堀紀雄, 星憲幸, 澤田智史, 柴田武士, 青木宏道
  • Organizer: 日本補綴歯科学会西関東支部会
  • Place of Presentation: 横浜
• [Presentation] 紫外線照射したショートインプラントの骨結合能の評価 (2010)
  • Author(s): 上野剛史、山田将博、堀紀雄、五十嵐順正、小川隆広
  • Organizer: 歯科チタン学会第23回学術会議
  • Place of Presentation: 東京