Development to new diagnostic procedure of pediatric OSAS and dental treatment by upper airway fluid simulation

• Project/Area Number: 22792061
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kagoshima University
• Principal Investigator: FUKAMI Atsushi 鹿児島大学, 医学部・歯学部附属病院, 助教 (20452948)
• Co-Investigator(Renkei-kenkyūsha): IWASAKI Tomonori 鹿児島大学, 医学部・歯学部附属病院, 講師 (10264433) ; YAMASAKI Youichi 鹿児島大学, 医歯(薬)学総合研究科, 教授 (30200645)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 小児OSAS / 上気道流体シミュレーション / 上顎骨急速拡大 / 鼻腔通気状態 / 舌位 / 咽頭気道体積 / 歯学 / 小児閉塞性睡眠時無呼吸症候群 / 通気障害部位の特定 / CT

Research Abstract

Fluid mechanical simulation (FMS) was proved effective for detecting the location of upper airway obstructions. The investigation clearly proved the effectiveness of combining FMS and CBCT to diagnose obstructions of the upper airway that might be important in planning OSAS treatment. And it was comprehensively examined that the effect of rapid maxillary expansion (RME) on the nasal airwayventilation condition, tongue posture and pharyngeal airway volume. RME enlarges the pharyngeal airway both with and without improvement in nasal obstruction. This effect is effective for OSAS of children.

Research Products

• [Journal Article] Tongue posture improvement and pharyngeal airway enlargement as secondary effects of rapid maxillary expansion: A cone-beam computed tomography study (2013)
  • Author(s): Iwasaki T, Saitoh I, Takemoto Y, Inada E, Kakuno E, Kanomi R, Hayasaki H, Yamasaki Y
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics Volume: Vol.143 Issue: 2 Pages: 235-245
  • DOI: 10.1016/j.ajodo.2012.09.014
  • Peer Reviewed
• [Journal Article] Evaluation of improvement of nasal airway ventilation following rapid maxillary expansion using computational fluid dynamics (2012)
  • Author(s): Iwasaki T, Saitoh I, Takemoto Y, Inada E, Kanomi R, Hayasaki H, Yamasaki Y
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics Volume: Vol.141, No.3 Issue: 3 Pages: 269-278
  • DOI: 10.1016/j.ajodo.2011.08.025
  • Peer Reviewed
• [Journal Article] Evaluation of upper airway obstruction in Class II children using fluid-mechanical simulation (2011)
  • Author(s): Iwasaki T, Saitoh I, Takemoto Y, Inada E, Kanomi R, Hayasaki H, Yamasaki Y
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: Vol.139, No.2 Issue: 2 Pages: e135-e145
  • DOI: 10.1016/j.ajodo.2010.08.014
  • Peer Reviewed
• [Journal Article] Development of Labial-Closure Strength in Preschool Children (2010)
  • Author(s): Fukami A, Saitoh I, Iwase Y, Oku T, Inada E, Takemoto Y, Yamada C, Iwasaki T, Hasegawa H, Kubota K, Murakami T, Harada K, Nishi M, Kinjo S, Igata N, Hayasaki H, Yamasaki Y
  • Journal Title: Journal of Craniomandibular Practice Volume: Vol.28, No.4 Pages: 232-237
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21032977
  • Peer Reviewed
• [Journal Article] Development of Labial-Closure Strength in Preschool Children. (2010)
  • Author(s): Atsushi Fukami
  • Journal Title: Journal of Craniomandibular Practice Volume: 28(4) Pages: 232-237
  • Peer Reviewed
• [Presentation] Detection of specific obstruction sites using fluid-structure interaction analysis in children with upper airway obstruction (2012)
  • Author(s): Iwasaki T, Saitoh I, Harada M, Miyashita K, Matsune S, Takemoto Y, Fukami A, Sato H, Inada E, Hasegawa H, Kakuno E, Kanomi R, Hayasaki H, Kurono Y, Yamasaki Y
  • Organizer: THE 7TH ASIAN SLEEP RESEAR SOCIETY CONGRESS
  • Place of Presentation: Taipei
  • Year and Date: 2012-11-30
• [Presentation] 進行性骨化性線維異形成症(FOP)患児への継続的口腔管理の一例 (2012)
  • Author(s): 深水 篤,長谷川大子,稲田絵美,佐藤秀夫,山崎要一
  • Organizer: 第30回日本小児歯科学会九州地方会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2012-10-28
• [Presentation] CBCTを用いた上顎骨側方急速拡大による舌位改善と咽頭気道拡大の評価 (2012)
  • Author(s): 岩崎智憲,嘉ノ海龍三,武元嘉彦,齊藤一誠,覚野恵梨子,早崎治明,山崎要一
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡市
  • Year and Date: 2012-09-28
• [Presentation] 上気道流体シミュレーションを用いた上顎骨急速拡大による歯科治療前後の吸気時咽頭気道圧の評価 (2012)
  • Author(s): 岩崎智憲, 齊藤一誠, 原田みずえ, 宮下圭一, 松根彰志, 武元嘉彦, 深水 篤, 佐藤秀夫, 稲田絵美, 長谷川大子, 覚野恵梨子,嘉ノ海龍三, 早崎治明, 黒野祐一, 山崎要一
  • Organizer: 第37回日本睡眠学会
  • Place of Presentation: 横浜市
  • Year and Date: 2012-06-29
• [Presentation] Improving tongue posture and pharynx airway as a side effect of rapid maxillary expansion in children: A cone-beam computed tomography study (2012)
  • Author(s): Iwasaki T, Saitoh I, Kanomi R, Hayasaki H, Yamasaki Y
  • Organizer: American Association of Orthodontists (AAO) 112th Annual Session
  • Place of Presentation: Honolulu
  • Year and Date: 2012-05-03
• [Presentation] Analysis of upper airway obstruction in Class II children using fluid-mechanical simulation, the 8th Biennial Conference of the Pediatric Dentistry Association of Asia (PDAA) (2012)
  • Author(s): Yamasaki Y, Iwasaki T, Saitoh I, Takemoto Y, Inada E, Kakuno E, Kanomi R, Hayasaki H
  • Organizer: The 5 finalists of Scientific competition in Research Poster Session.
  • Place of Presentation: Sanur Paradisw Plaza Hotel, Bali in Indonesia
• [Presentation] 小児の口呼吸における関連因子の抽出と口唇閉鎖力との関連性についての先行研究 (2012)
  • Author(s): 村上大輔,稲田絵美,齊藤一誠,海原康孝,奥 猛志,岩崎智憲,長谷川大子,深水 篤,佐藤秀夫,武元嘉彦,窪田直子,伊藤千晶,乃村俊樹,田中みゆき,井形紀子,香西克之,山崎要一
  • Organizer: 第50回日本小児歯科学会大会
  • Place of Presentation: 東京
• [Presentation] 上気道流体シミュレーションを用いた上顎骨急速拡大による歯科治療前後の吸気時咽頭気道圧の評価 (2012)
  • Author(s): 岩崎智憲
  • Organizer: 第37回日本睡眠学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 反対咬合を主訴に来院し、閉塞性睡眠時無呼吸症候群を認めた症例 (2011)
  • Author(s): 武元嘉彦, 他
  • Organizer: 第30回日本小児歯科学会中四国地方会大会および総会,第29回日本小児歯科学会九州地方会大会および総会
  • Place of Presentation: 北九州市・九州歯科大学
• [Presentation] 顎顔面表面形状の男女成長量に関する横断的研究 (2010)
  • Author(s): 新海みゆき
  • Organizer: 第28回日本小児歯科学会九州地方会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-10-03
• [Presentation] 抗てんかん薬を投与されている心身障害者において、術前の肝機能障害が静脈内鎮静法の覚醒時間に及ぼす影響 (2010)
  • Author(s): 糀谷淳
  • Organizer: 第27回日本障害者歯科学会大会
  • Place of Presentation: 東京