Investigation of redox regulation by Keap-1 and Nrf2 system in periodontal tissue
| Project/Area Number |
22792089
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
BANDO Mika 徳島大学, 病院, 医員 (10510000)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 歯周組織由来細胞 / 酸化ストレス / Keap1-Nrf2 / 歯肉上皮細胞 |
|---|
| Research Abstract |
The aim of this study is investigation of redox regulation in periodontal tissue to use antioxidative stress mechanism(Keap1-Nrf2 system) as new periodontitis prevention and treatment. This study show Porphyromonas gingivalis(p. g.) LPS induced oxidative stress and the antioxidant response in human gingival fibroblast. keratinocyte growth factor(KGF) induced antioxidative enzyme(HO-1) and antioxidant response-transcriptional factor(Nrf2) expressions. KGF may enhance antioxidative stress mechanism in periodontal tissue.
|
Report
(3 results)
Research Products
(7 results)
