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Development of a new antimicrobial agent therapy to planperiodontal pocket reduction

Research Project

Project/Area Number 22792101
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionTsurumi University

Principal Investigator

NAGANO Takatoshi  鶴見大学, 歯学部, 講師 (10386914)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯学 / 細胞・組織 / 歯周薬物療法 / ヒト歯肉線維芽細胞 / ヒト歯根膜細胞 / アジスロマイシン / IL-6 / IL-8 / NF-κB / インターロイキン-6 / インターロイキン-8
Research Abstract

We investigated the effects of AZM on human gingival fibroblasts (hGFs) and human periodontal ligament cells (hPDLFs) by measuring the expression levels of the inflammatory cytokines IL-6 and IL-8, as well as MMP-1, and TIMP-1 and which are associated with connective tissue remodeling.The mRNA expression of IL-6 and IL-8 in hGFs was upregulated by AZM dose-dependently under LPS stimulation conditions. However, hPDLFs showed no association between AZM and IL-6 or IL-8. The hGFs upregulated MMP-1 and TIMP-1 in response to AZM dose-dependently.In addition, the hPDLFs did not exhibit differences in expression of MMP-1, MMP-2, TIMP-1, or TIMP-2.We speculate that such highly concentrated AZM would be able to supress periodontal pathogenic bacteria, destroy an already formed biofilms and periodontal pocket reduction in short time period.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Presentation (7 results)

  • [Presentation] アジスロマイシンによる歯肉線維芽細胞 の炎症性サイトカイン産生亢進2012

    • Author(s)
      山口貴央、 長野 孝俊 、五味一博、 桃井保子
    • Organizer
      第55回春季日本歯周 病学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] アジスロマイシンによる歯肉線維芽細胞の炎症性サイトカイン産生亢進2012

    • Author(s)
      長野 孝俊
    • Organizer
      第55回日本歯周病学会学術大会
    • Place of Presentation
      北海道・札幌コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] アジスロマイシンによる歯肉線維芽細胞の炎症性サイトカイン産生亢進2012

    • Author(s)
      山口貴央、長野孝俊、五味一博、桃井保子
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      北海道・札幌コンベンションセンター(発表確定)
    • Related Report
      2011 Annual Research Report
  • [Presentation] アジスロマイシンの歯肉および歯根膜 線維芽細胞に及ぼす影響2011

    • Author(s)
      長 野孝俊 、 山口貴央、近藤由佳、 田村紗恵子、五味一博、新井 高
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] アジスロマイシンの歯肉および歯根膜線維芽細胞に及ぼす影響2011

    • Author(s)
      長野孝俊, 他5名
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡県・福岡国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Azithromycin to Gingival and Periodontal Ligament Fibroblasts2010

    • Author(s)
      K. Gomi, Y. Yamaguchi, T. Nagano, Y.Momoi, T. Arai
    • Organizer
      AAP 96th AnnualMeeting
    • Place of Presentation
      Honolulu, U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of Azithromycin to Gingival and Periodontal Ligament Fibroblasts2010

    • Author(s)
      K.Gomi, Y.Yamaguchi, T.Nagano, Y.Momoi, T.Arai
    • Organizer
      AAP 96th Annual Meeting
    • Place of Presentation
      Honolulu, U.S.A
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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