| Budget Amount *help |
¥4,784,000 (Direct Cost: ¥3,680,000、Indirect Cost: ¥1,104,000)
Fiscal Year 2012: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2011: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Research Abstract |
Estrogens are originally identified as the primary sex steroid hormone in females regulating reproductive function and sexual behavior. It has long been suggested that estroge ns also have effects on the somatosensory system. It is generally and clinically well known that specific itch sensation is increased during the periods when circulating sex steroid hormone levels were dramatically changed such as pregnancy and climacterium. However, little is known whether itch threshold is related to estrogen level. In this study, we investigated the estrogen effects on itch sensation using behavioral pharmacological and histological analyses. Our results suggest that itch sensation is regulated by the circulating estrogen level in female rats, and raise the possibility that estrogens may regulate itch sensation by changes in CGRP expression in somatosensory system.
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