胆管癌のmolecular subtype分類の構築

• Project/Area Number: 22K08775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Okayama University
• Principal Investigator: 楳田 祐三 岡山大学, 医歯薬学域, 准教授 (10573735)
• Co-Investigator(Kenkyū-buntansha): 藤原 俊義 岡山大学, 医歯薬学域, 教授 (00304303) ; 八木 孝仁 岡山大学, 大学病院, 教授 (00304353) ; 永坂 岳司 川崎医科大学, 医学部, 教授 (30452569) ; 吉田 一博 岡山大学, 医学部, 客員研究員 (60824761) ; 重安 邦俊 岡山大学, 大学病院, 助教 (70544071)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2024: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝内胆管癌 / 胆管癌 / 腫瘍免疫

Outline of Research at the Start

胆道癌は、予後不良の難治癌として知られている。本研究では、胆道癌を対象に、genetic/epigenetic変異をはじめとする遺伝子変異と腫瘍免疫応答をバイオマーカーに、 Oncological resectability（腫瘍学的切除可能）症例の拾い上げを可能とする胆道癌のsub-type分類を試み、更に簡便に腫瘍病勢評価が可能なLiquid Biopsyへの応用を試みる。

Outline of Annual Research Achievements

1. これまで岡山大学病院肝胆膵外科にて行われた肝内胆管癌切除症例より組織サンプルを収集・保存し、DNA抽出を行った。更に、関連病院を含め前向きに収集してきた肝内胆管癌患者の術前・術後血液サンプルの解析を進めている。
2. 腫瘍・宿主免疫応答評価として、各種免疫栄養指標の評価を算出し、再 発予後・生存予後との比較を行った。
また肝内胆管癌切除標本より、腫瘍局所における腫瘍関連免疫反応を評価し、全身免疫栄養指標との関連性を検討すること で、末梢血液における免疫指標の意義を検討している。腫瘍内外における腫瘍浸潤T細胞(Tumor Infiltrating Lymphocyte)を免疫組織染色にて把 握し、CD8/Foxp3を用いた機能評価・スコア化を行った。これまでの解析より、術前の免疫栄養指標は鋭敏に肝内胆管癌の切除予後を反映することを明らかにした。
3. バイオインフォマティックアプローチを用いて4つの候補遺伝子に絞り込み、パラフィン切片から抽出したRNAに対してRT-qPCRを行い、それら４遺伝子の発現について制御性T細胞との関連を検証した。更に、肝内胆管癌の発癌への炎症関与に着目し、RNA編集酵素であるADAR1についてもその発現と腫瘍免疫環境と腫瘍抗原との関連性について免疫染色法で検証し、ADAR1高発現の肝内胆管癌は予後不良であり、FoxP3と弱い相関がみられた。 現在、細胞株および血液中から単離したPBMC、FoxP3を用いて、これら因子が免疫環境に与える影響について検証中である。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

今回、制御性T細胞の抗原認識メカニズムに着目し、４つの候補遺伝子に絞り込んで解析を進めたが、切除標本における腫瘍内発現が少なく、予想された結果が得られなかった。また肝内胆管癌の発癌に炎症が関与していることに着目し、RNA編集酵素であるADAR1に着目して解析を新たに進めていることから、研究全体に遅延を生じている。

Strategy for Future Research Activity

新たに着目したRNA編集酵素と抑制性免疫環境との関連性について、これまでの組織サンプル解析とともに血液検体を用いて解析を進めていく予定である。今後は、幅広く集積した切除標本・血液サ ンプルをValidation cohortとして、本学で得られた実験結果を再度検証していく予定である。

Research Products

• [Journal Article] Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles (2024)
  • Author(s): Yasui Kazuya、Toshima Toshiaki、Inada Ryo、Umeda Yuzo、Yano Shuya、Tanioka Hiroaki、Nyuya Akihiro、Fujiwara Toshiyoshi、Yamada Takeshi、Naomoto Yoshio、Goel Ajay、Nagasaka Takeshi
  • Journal Title: Molecular Cancer Volume: 23 Issue: 1
  • DOI: 10.1186/s12943-023-01910-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of robotic surgery as an element of Enhanced Recovery After Surgery protocol in patients undergoing pancreatoduodenectomy (2024)
  • Author(s): Takagi Kosei、Umeda Yuzo、Fuji Tomokazu、Yasui Kazuya、Yamada Motohiko、Kimura Jiro、Fujiwara Toshiyoshi
  • Journal Title: Journal of Gastrointestinal Surgery Volume: 28 Issue: 3 Pages: 220-225
  • DOI: 10.1016/j.gassur.2023.12.017
  • Peer Reviewed / Open Access
• [Journal Article] Epidural <i>versus</i> patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial (2024)
  • Author(s): Kikuchi Satoru、Matsusaki Takashi、Mitsuhashi Toshiharu、Kuroda Shinji、Kashima Hajime、Takata Nobuo、Mitsui Ema、Kakiuchi Yoshihiko、Noma Kazuhiro、Umeda Yuzo、Morimatsu Hiroshi、Fujiwara Toshiyoshi
  • Journal Title: BJS Open Volume: 8 Issue: 1
  • DOI: 10.1093/bjsopen/zrad161
  • Peer Reviewed / Open Access
• [Journal Article] 制御性T細胞による肝内胆管癌の免疫微小環境の制御 (2024)
  • Author(s): 吉田一博、楳田祐三、重安邦俊、藤智和、安井和也、高木弘誠、藤原俊義
  • Journal Title: 肝胆膵 Volume: 88 Pages: 619-624
• [Journal Article] Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma (2023)
  • Author(s): Yoshimoto Masashi、Kagawa Shunsuke、Kajioka Hiroki、Taniguchi Atsuki、Kuroda Shinji、Kikuchi Satoru、Kakiuchi Yoshihiko、Yagi Tomohiko、Nogi Shohei、Teraishi Fuminori、Shigeyasu Kunitoshi、Yoshida Ryuichi、Umeda Yuzo、Noma Kazuhiro、Tazawa Hiroshi、Fujiwara Toshiyoshi
  • Journal Title: Cancer Letters Volume: 567 Pages: 216260-216260
  • DOI: 10.1016/j.canlet.2023.216260
  • Peer Reviewed / Open Access
• [Journal Article] Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts (2023)
  • Author(s): Beumer Berend R.、Takagi Kosei、Buettner Stefan、Umeda Yuzo、Yagi Takahito、Fujiwara Toshiyoshi、van Vugt Jeroen L.A.、IJzermans Jan N.M.
  • Journal Title: International Journal of Surgery Volume: 109 Issue: 8 Pages: 2258-2266
  • DOI: 10.1097/js9.0000000000000458
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robotic Pancreatoduodenectomy in Portal Annular Pancreas Using a Hanging Maneuver with Indocyanine Green Fluorescence Imaging (2023)
  • Author(s): Takagi Kosei、Fuji Tomokazu、Yamada Motohiko、Kimura Jiro、Yasui Kazuya、Umeda Yuzo、Fujiwara Toshiyoshi
  • Journal Title: Annals of Surgical Oncology Volume: 31 Issue: 3 Pages: 1933-1936
  • DOI: 10.1245/s10434-023-14685-9
  • Peer Reviewed / Open Access
• [Journal Article] Innovative suture technique for robotic hepaticojejunostomy: double-layer interrupted sutures (2023)
  • Author(s): Takagi Kosei、Umeda Yuzo、Yoshida Ryuichi、Fuji Tomokazu、Yasui Kazuya、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Langenbeck's Archives of Surgery Volume: 408 Issue: 1 Pages: 284-284
  • DOI: 10.1007/s00423-023-03020-1
  • Peer Reviewed / Open Access
• [Journal Article] Impact of cancer-associated fibroblasts on survival of patients with ampullary carcinoma (2023)
  • Author(s): Takagi Kosei、Noma Kazuhiro、Nagai Yasuo、Kikuchi Satoru、Umeda Yuzo、Yoshida Ryuichi、Fuji Tomokazu、Yasui Kazuya、Tanaka Takehiro、Kashima Hajime、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Frontiers in Oncology Volume: 13
  • DOI: 10.3389/fonc.2023.1072106
  • Peer Reviewed / Open Access
• [Journal Article] Impact of educational video on performance in robotic simulation training (TAKUMI-1): a randomized controlled trial (2023)
  • Author(s): Takagi Kosei、Hata Nanako、Kimura Jiro、Kikuchi Satoru、Noma Kazuhiro、Yasui Kazuya、Fuji Tomokazu、Yoshida Ryuichi、Umeda Yuzo、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Journal of Robotic Surgery Volume: - Issue: 4 Pages: 1547-1553
  • DOI: 10.1007/s11701-023-01556-4
  • Peer Reviewed / Open Access
• [Journal Article] Robotic liver resection for hepatic cyst using indocyanine-green fluorescence imaging (2023)
  • Author(s): Takagi Kosei、Umeda Yuzo、Kimura Jiro、Yagi Takahito
  • Journal Title: Asian Journal of Surgery Volume: 46 Issue: 4 Pages: 1839-1841
  • DOI: 10.1016/j.asjsur.2022.10.059
  • Peer Reviewed / Open Access
• [Journal Article] Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer (2023)
  • Author(s): Kajiwara Y, Tazawa H, Yamada S, Kanaya N, Fushimi T, Kikuchi S, Kuroda S, Ohara T, Noma K, Yoshida R, Umeda Y, Urata Y, Kagawa S, Fujiwara T
  • Journal Title: Cancer Immunol Immunother Volume: 72 Issue: 5 Pages: 1285-1300
  • DOI: 10.1007/s00262-022-03334-x
  • Peer Reviewed
• [Journal Article] Robotic distal pancreatectomy using a medial approach for a bulky mucinous cystic neoplasm of the pancreas (with video) (2022)
  • Author(s): Kosei Takagi, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi
  • Journal Title: Asian J Surg . Volume: 45 Issue: 1 Pages: 542-543
  • DOI: 10.1016/j.asjsur.2021.09.009
  • Peer Reviewed / Open Access
• [Journal Article] Robotic spleen-preserving distal pancreatectomy using indocyanine green fluorescence imaging (with video). (2022)
  • Author(s): Takagi K, Umeda Y, Yoshida R, Yagi T.
  • Journal Title: Asian J Surg. Volume: 45 (1) Issue: 1 Pages: 596-597
  • DOI: 10.1016/j.asjsur.2021.10.005
  • Peer Reviewed / Open Access
• [Journal Article] Surgical technique of suprapancreatic D2 lymphadenectomy focusing on the posterior hepatic plexus for advanced gastric cancer. (2022)
  • Author(s): Kanaya N, Kuroda S, Kakiuchi Y, Takeda S, Kikuchi S, Noma K, Yoshida R, Umeda Y, Teraishi F, Nishizaki M, Kagawa S, Fujiwara T.
  • Journal Title: Langenbecks Arch Surg. Volume: 407 (2) Issue: 2 Pages: 871-877
  • DOI: 10.1007/s00423-022-02437-4
  • Peer Reviewed
• [Journal Article] A Systematic Review of Minimally Invasive Versus Open Radical Antegrade Modular Pancreatosplenectomy for Pancreatic Cancer. (2022)
  • Author(s): Takagi K, Umeda Y, Yoshida R, Yagi T, Fujiwara T.
  • Journal Title: Anticancer Res. Volume: 42 (2) Issue: 2 Pages: 653-660
  • DOI: 10.21873/anticanres.15523
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms. (2022)
  • Author(s): Matsumoto K, Ohara T, Fujisawa M, Takaki A, Takahara M, Kato H, Yoshida R, Umeda Y, Yagi T, Matsukawa A, Okada H.
  • Journal Title: J Gastrointest Surg. Volume: - Issue: 6 Pages: 1213-1223
  • DOI: 10.1007/s11605-021-05197-6
  • Peer Reviewed / Open Access
• [Journal Article] Surgical resection of mixed neuroendocrine-non-neuroendocrine neoplasm in the biliary system: a report of two cases (2022)
  • Author(s): Tamaki Ayano、Tani Yuma、Sato Hiroki、Yoshida Ryuichi、Yasui Kazuya、Horiguchi Shigeru、Kuise Takashi、Umeda Yuzo、Yoshida Kazuhiro、Fuji Tomokazu、Kumano Kenjiro、Takagi Kosei、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Surgical Case Reports Volume: 8 Issue: 1 Pages: 38-38
  • DOI: 10.1186/s40792-022-01386-w
  • Peer Reviewed
• [Journal Article] Prognostic Value of the Regional Lymph Node Station in Pancreatoduodenectomy for Ampullary Carcinoma. (2022)
  • Author(s): Takagi K, Nagai Y, Umeda Y, Yoshida R, Yoshida K, Fuji T, Kumano K, Yasui K, Yagi T, Fujiwara T.
  • Journal Title: In Vivo. Volume: 36 (2) Issue: 2 Pages: 973-978
  • DOI: 10.21873/invivo.12789
  • Peer Reviewed / Open Access
• [Journal Article] The Gastrohepatic Ligament Approach in Robotic Spleen-Preserving Distal Pancreatectomy with Resection of the Splenic Vessels: The Superior Window Approach in the Warshaw Technique. (2022)
  • Author(s): Takagi K, Umeda Y, Yoshida R, Yagi T, Fujiwara T.
  • Journal Title: J Gastrointest Surg. Volume: - Issue: 6 Pages: 1342-1344
  • DOI: 10.1007/s11605-022-05286-0
  • Peer Reviewed
• [Journal Article] Division of the pancreas at the right side of the superior mesenteric vein in robotic distal pancreatectomy: The splenic vessel-first approach (2022)
  • Author(s): Takagi Kosei、Yoshida Ryuichi、Umeda Yuzo、Yagi Takahito
  • Journal Title: Asian Journal of Surgery Volume: 45 Issue: 8 Pages: 1591-1593
  • DOI: 10.1016/j.asjsur.2022.03.036
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of the Regional Lymph Node Station in Pancreatic Neuroendocrine Tumor. (2022)
  • Author(s): Takagi K, Umeda Y, Yoshida R, Yoshida K, Fuji T, Kumano K, Yasui K, Yagi T, Fujiwara T.
  • Journal Title: Anticancer Res. Volume: 42 (5) Issue: 5 Pages: 2797-2801
  • DOI: 10.21873/anticanres.15760
  • Peer Reviewed
• [Journal Article] Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma (2022)
  • Author(s): Konishi DaisukeKishimoto Hiroyuki、Michiue Hiroyuki、Teraishi Fuminori、Kato Hironari、Tazawa Hiroshi、Yanai Hiroyuki、Yagi Takahito、Goel Ajay、Fujiwara Toshiyoshi
  • Journal Title: British Journal of Cancer Volume: 127 Issue: 4 Pages: 757-765
  • DOI: 10.1038/s41416-022-01838-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adenomatoid mesothelioma arising from the diaphragm: a case report and review of the?literature (2022)
  • Author(s): Kawabe Kenta、Sato Hiroki、Kitano Akiko、Yoshida Ryuichi、Yasui Kazuya、Umeda Yuzo、Yoshida Kazuhiro、Fuji Tomokazu、Kumano Kenjiro、Takagi Kosei、Kagoura Masaaki、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Journal of Medical Case Reports Volume: 16 Issue: 1 Pages: 228-228
  • DOI: 10.1186/s13256-022-03420-9
  • Peer Reviewed
• [Journal Article] Feasibility of local therapy for recurrent pancreatic cancer (2022)
  • Author(s): Sato Hiroki、Yoshida Ryuichi、Yasui Kazuya、Umeda Yuzo、Yoshida Kazuhiro、Fuji Tomokazu、Kumano Kenjiro、Takagi Kosei、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Pancreatology Volume: 22 Issue: 6 Pages: 774-781
  • DOI: 10.1016/j.pan.2022.05.004
  • Peer Reviewed
• [Journal Article] Optimal surveillance of intraductal papillary mucinous neoplasms of the pancreas focusing on remnant pancreas recurrence after surgical resection (2022)
  • Author(s): Fuji Tomokazu、Umeda Yuzo、Takagi Kosei、Yoshida Ryuichi、Yoshida Kazuhiro、Yasui Kazuya、Matsumoto Kazuyuki、Kato Hironari、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: BMC Cancer Volume: 22 Issue: 1 Pages: 588-588
  • DOI: 10.1186/s12885-022-09650-w
  • Peer Reviewed / Open Access
• [Journal Article] Favorable control of hepatocellular carcinoma with peritoneal dissemination by surgical resection using indocyanine green fluorescence imaging: a case report and review of the literature? (2022)
  • Author(s): Tani Yuma、Sato Hiroki、Yoshida Ryuichi、Yasui Kazuya、Umeda Yuzo、Yoshida Kazuhiro、Fuji Tomokazu、Kumano Kenjiro、Takagi Kosei、Kagoura Masaaki、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Journal of Medical Case Reports Volume: 16 Issue: 1 Pages: 222-222
  • DOI: 10.1186/s13256-022-03440-5
  • Peer Reviewed
• [Journal Article] Impact of Amino Acids Nutrition Following Gastrectomy in Gastric Cancer Patients (2022)
  • Author(s): KIKUCHI SATORU、TAKATA NOBUO、KURODA SHINJI、UMEDA HIBIKI、TANABE SHUNSUKE、MAEDA NAOAKI、TAKAGI KOSEI、NOMA KAZUHIRO、HASEGAWA YUKO、NAWACHI KUMIKO、KAGAWA SHUNSUKE、UMEDA YUZO、SHIKATA KENICHI、FUJIWARA TOSHIYOSHI
  • Journal Title: Anticancer Research Volume: 42 Issue: 7 Pages: 3637-3643
  • DOI: 10.21873/anticanres.15852
  • Peer Reviewed
• [Journal Article] RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer (2022)
  • Author(s): Komatsu Yasuhiro、Shigeyasu Kunitoshi、Kagawa Shunsuke、Michiue Hiroyuki、Tazawa Hiroshi、Goel Ajay、Fujiwara Toshiyoshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 00-00
  • DOI: 10.1038/s41598-022-17773-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical Strategies to Approaching the Splenic Artery in Robotic Distal Pancreatectomy (2022)
  • Author(s): TAKAGI KOSEI、KUMANO KENJIRO、UMEDA YUZO、YOSHIDA RYUICHI、FUJI TOMOKAZU、YASUI KAZUYA、YAGI TAKAHITO、FUJIWARA TOSHIYOSHI
  • Journal Title: Anticancer Research Volume: 42 Issue: 9 Pages: 4471-4476
  • DOI: 10.21873/anticanres.15947
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Patient-Participation Continuous Nutritional Counseling in Gastric Cancer Patients who Underwent Gastrectomy (2022)
  • Author(s): Takata Nobuo、Kikuchi Satoru、Kuroda Shinji、Tanabe Shunsuke、Maeda Naoaki、Noma Kazuhiro、Takahashi Ayako、Umeda Yuzo、Shikata Kenichi、Ozaki Kazuhide、Fujiwara Toshiyoshi
  • Journal Title: Annals of Surgical Oncology Volume: 30 Issue: 2 Pages: 1110-1118
  • DOI: 10.1245/s10434-022-12572-3
• [Journal Article] Robotic Spleen-Preserving Distal Pancreatectomy with Preservation of Splenic Vessels Using the Gastrohepatic Ligament Approach: The Superior Window Approach in the Kimura Technique (2022)
  • Author(s): Takagi Kosei、Yoshida Ryuichi、Umeda Yuzo、Fuji Tomokazu、Yasui Kazuya、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Digestive Surgery Volume: 39 Issue: 4 Pages: 137-140
  • DOI: 10.1159/000527249
  • Peer Reviewed
• [Journal Article] Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer (2022)
  • Author(s): Araki H, Tazawa H, Kanaya N, Kajiwara Y, Yamada M, Hashimoto M, Kikuchi S, Kuroda S, Yoshida R, Umeda Y, Urata Y, Kagawa S, Fujiwara T
  • Journal Title: Mol Ther Oncolytics Volume: 27 Pages: 3-13
  • DOI: 10.1016/j.omto.2022.09.003
  • Peer Reviewed / Open Access
• [Journal Article] Surgical Strategies to Dissect around the Superior Mesenteric Artery in Robotic Pancreatoduodenectomy (2022)
  • Author(s): Takagi Kosei、Umeda Yuzo、Yoshida Ryuichi、Fuji Tomokazu、Yasui Kazuya、Kimura Jiro、Hata Nanako、Mishima Kento、Yagi Takahito、Fujiwara Toshiyoshi
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 23 Pages: 7112-7112
  • DOI: 10.3390/jcm11237112
  • Peer Reviewed / Open Access
• [Journal Article] Surgical Outcomes of Laparoscopic versus Open Hepatectomy for Left Hepatocellular Carcinoma: Propensity Score Analyses Using Retrospective Japanese and Korean Individual Patient Data (2022)
  • Author(s): Kaibori M, Yoshii K, Umeda Y, Yagi T, Okabayashi T, Sui K, Mori A, Hamaguchi Y, Kajiyama K, Hokuto D, Monden K, Yoshizumi T, Nomura Y, Toriguchi K, Kim JM, Choi GH, Ryu JH, Koh Y, Kang KJ, You YK, Chun KS, Han YS, Cho CW, Choi YI, Kim DS, Yang JD, Mori K, Hiraoka A, Yamaue H, Nakamura M, Yamamoto M, Endo I.
  • Journal Title: Liver Cancer Volume: 12 Issue: 1 Pages: 32-43
  • DOI: 10.1159/000527294
  • Peer Reviewed / Open Access
• [Presentation] Surgical approach to colorectal liver metastases with extrahepatic metastasis:A multi-institutional study by the Okayama Study Group of HBP surgery (2023)
  • Author(s): Fuji T, Umeda Y, Monden K, Kojima T, Inagaki Y, Endo Y, Sui K, Yagi T, Fujiwara T.
  • Organizer: 第35回日本肝胆膵外科学会学術集会
• [Presentation] 血中循環腫瘍DNA内KRAS mutation profileとCA19-9値を組み合わせた膵癌予後の層別化戦略 (2023)
  • Author(s): 安井和也, 吉田龍一, 宮本耕吉, 藤智和, 高木弘誠, 寺石文則, 黒田新士, 野間和広, 楳田祐三, 藤原俊義
  • Organizer: 第78回日本消化器外科学会総会
• [Presentation] Short outcomes of adjuvant immunotherapy for esophageal cancer in our institution (2023)
  • Author(s): Hashimoto M, Noma K, Kawasaki K, Kato T, Maeda N, Kikuchi S, Shigeyasu K, Kondo Y, Tanabe S, Kuroda S,Teraishi F, Umeda Y, Kagawa S, Shirakawa Y, Fuhiwara T
  • Organizer: the Asian Oncology Society (AOS2023)
  • Int'l Joint Research
• [Presentation] Surgical management of borderline resectable colorectal liver metastases: vessel-skeletonized parenchymasparing hepatectomy (VESPAH) (2023)
  • Author(s): Umeda Y, Fuji T, Takagi K, Yasui K, Shigeyasu K, Kuroda S, Noma K, Teraishi F, Fujiwara T
  • Organizer: the Asian Oncology Society (AOS2023)
  • Int'l Joint Research
• [Presentation] Management of HCC-recurrence after liver transplantation: Lessons from aggressive and tenacious surgical approach (2023)
  • Author(s): Umeda Y, Fuji T, Fujiwara T
  • Organizer: JDDW2023
• [Presentation] Optimal treatment for recurrent intrahepatic cholangiocarcinoma: when do we do surgery? (2022)
  • Author(s): Yuzo Umeda
  • Organizer: The 31st conference of the Asian Pacific Association for the study of the liver (APASL) 2022, Seoul
  • Int'l Joint Research / Invited
• [Presentation] Prognostic significance of GATA6 expression after surgery in patients with pancreatic cancer (2022)
  • Author(s): Yoshida R,Miyamoto K,Shigeyasu K,Yasui K,Takagi K,Fuji T,Umeda Y,Yagi T,FujiwaraT
  • Organizer: 第53回日本膵臓学会大会・第26回国際膵臓学会
  • Int'l Joint Research
• [Presentation] Analysis of resection margin status in pancreatectomy for pancreati ductal adenocarcinoma (2022)
  • Author(s): Yasui K,Yoshida R,Miyamoto K,Umeda Y,Fuji T,Takagi K,Yagi T,Fujiwara T
  • Organizer: 第53回日本膵臓学会大会・第26回国際膵臓学会
  • Int'l Joint Research
• [Presentation] Combination analysis of pre- and postoperative KRAS mutation in circulating tumor DNA in patients with pancreatic cancer (2022)
  • Author(s): Miyamoto K,Yoshida R,Shigeyasu K,Yasui K,Takagi K,Fuji T,Umeda Y,Yagi T,Fujiwara T
  • Organizer: 第53回日本膵臓学会大会・第26回国際膵臓学会
  • Int'l Joint Research
• [Presentation] BR大腸癌肝転移に対する肝切除アプローチ Vessel-Skeletonized Parenchyma-sparing Hepatectomyの有用性 (2022)
  • Author(s): 楳田祐三、藤智和、高木弘誠、安井和也、黒田新士、吉田龍一、野間和広、寺石文則、八木孝仁、藤原俊義
  • Organizer: 第77回日本消化器外科学会総会
• [Presentation] Efficacy of Surgical Management for Recurrent Intrahepatic Cholangiocarcinoma (2022)
  • Author(s): Yuzo Umeda
  • Organizer: APASL Oncology 2022
  • Int'l Joint Research / Invited
• [Presentation] 血中循環腫瘍DNA内Kras遺伝子変異情報とCA19-9値による切除可能膵癌層別化の試み (2022)
  • Author(s): 吉田龍一、宮本耕吉、楳田祐三、藤智和、安井和也、高木弘誠、八木孝仁、藤原俊義
  • Organizer: 第84回日本臨床外科学会総会
• [Presentation] The surgical technique of biliary and vascular reconstruction in robotic pancreatoduodenectomy lessons from the Dutch training system (2022)
  • Author(s): Umeda Y,Takagi K,Yoshida R,Yoshida K,Fuji T,Yasui K,Yagi T,Fujiwara T
  • Organizer: ACRLS2022
  • Int'l Joint Research / Invited
• [Presentation] Robotic radical antegrade modular pancreatosplenectomy for pancreatic body cancer (2022)
  • Author(s): Takagi K,Umeda Y,Yoshida R,Fuji T,Yasui K,Yagi T,Fujiwara T
  • Organizer: ACRLS2022
  • Int'l Joint Research / Invited
• [Presentation] Standardization of surgical technique in robotic pancreatoduodenectomy lessons from the Dutch training system (2022)
  • Author(s): Takagi K,Umeda Y,Yoshida R,Fuji T,Yasui K,Yagi T,Fujiwara T
  • Organizer: ACRLS2022
  • Int'l Joint Research / Invited
• [Presentation] 胆道癌に対する外科治療Up to date (2022)
  • Author(s): 楳田祐三
  • Organizer: 第17回五国胆膵画像診断研究会
  • Invited