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Machine learning models for predicting cognitive decline based on long-term longitudinal data

Research Project

Project/Area Number 22K10074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionOsaka University

Principal Investigator

Takahashi Toshihito  大阪大学, 大学院歯学研究科, 招へい教員 (70610864)

Co-Investigator(Kenkyū-buntansha) 野崎 一徳  大阪大学, 歯学部附属病院, 准教授 (40379110)
豆野 智昭  大阪大学, 大学院歯学研究科, 助教 (50845922)
八田 昂大  大阪大学, 大学院歯学研究科, 招へい教員 (60845949)
Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords高齢者 / 認知機能 / 認知症 / 機械学習
Outline of Research at the Start

2010年から地域在住高齢者を対象者とした,約3000名を対象とした学際的な大規模コホートの縦断調査を行ってきており,今後もさらにデータを収集する予定である.
令和4年度は70歳コホートの12年後の追跡調査を行う.また,これまでの調査により得られた9年間の追跡調査データを用いて,ベースライン調査時から3年後,6年後,9年後の認知機能の低下についての予測モデルを作成する.同様に令和5年度は80歳コホートを,令和6年度は90歳コホートを対象に,それぞれ12年後の追跡調査を行う.そして,得られた全コホートのデータを統合して認知機能低下の12年予測モデルを作成する.

Outline of Final Research Achievements

As our country enters a super-aged society, it is crucial to predict the onset of diseases that lead to the need for long-term care, as well as their risk factors, for each elderly individual. By doing so, appropriate measures can be implemented to help as many elderly people as possible maintain independent lives.
With this in mind, we focused on dementia, which is a major cause of the need for long-term care. Based on the hypothesis that "if the onset of dementia can be predicted from oral conditions, preventive care can be achieved through dental approaches," we aim to develop a machine learning model to predict Cognitive declin. This model will be built using data from a 12-year longitudinal study involving 3,000 participants and analyzing a vast number of factors, including oral health conditions.

Academic Significance and Societal Importance of the Research Achievements

本研究で作成する認知機能低下予測モデルは,健康長寿の要因を探るため10年以上にわたり,3000名もの学際的な大規模長期縦断調査,老年学研究により得られた身体的因子,社会的因子,心理的因子のデータに,口腔因子(残存歯数や歯周病の状態など)や口腔機能(咬合力や唾液分泌機能など)のデータを加えた包括的なデータに基づいたものである.
したがって,本研究で作成された予測モデルは,口腔に関するデータ以外も考慮されているだけでなく,これまでにない長期的な予測が可能な信頼性の高い予測モデルであると思われる.

Report

(4 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (3 results)

All 2024 2023

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Exploring the association between number of teeth, food intake, and cognitive function: A 9-year longitudinal study2024

    • Author(s)
      Mameno T、Moynihan P、Nakagawa T、Inagaki H、Akema S、Murotani Y、Takeuchi S、Kimura A、Okada Y、Tsujioka Y、Higashi K、Hagino H、Mihara Y、Kosaka T、Takahashi T、Wada M、Gondo Y、Kamide K、Akasaka H、Kabayama M、Ishizaki T、Masui Y、Ikebe K
    • Journal Title

      Journal of Dentistry

      Volume: 145 Pages: 104991-104991

    • DOI

      10.1016/j.jdent.2024.104991

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk factors of cognitive impairment: Impact of decline in oral function2023

    • Author(s)
      Takahashi T, Hatta K, Ikebe K
    • Journal Title

      Jpn Dent Sci Rev

      Volume: 59 Pages: 203-208

    • DOI

      10.1016/j.jdsr.2023.06.006

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Causal relationships between cognitive decline and oral factors revealed by structural equation models2023

    • Author(s)
      Higashi K, Takahashi T, Mameno T, Nozaki K, Hatta K, Murotani Y, Tsujioka Y, Akema S, Seto E, Okada Y, Takeuchi S, Mihara Y, Wada M, Maeda Y, Ikebe K
    • Organizer
      ECG Annual Congress Stockholm 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2022-04-19   Modified: 2026-01-16  

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