| Project/Area Number |
22K12833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
劉 学瑩 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (30777470)
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| Co-Investigator(Kenkyū-buntansha) |
喜納 宏昭 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主幹研究員 (70283067)
Quader Sabina 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 副主幹研究員 (90749699)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Nanomedicine / ICIs / medulloblastoma / chemo-immunotherapy / childhood cancers / Chemo-immunotherapy / pH-triggered / Medulloblastoma |
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| Outline of Research at the Start |
This research proposal aims to evaluate the potential use of a tumor pH-triggered Nanomedicine loaded with pediatric brain cancer drug combined with ICI therapy in a syngeneic Medulloblastoma mouse model.
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| Outline of Annual Research Achievements |
We have successfully developed and confirmed the effectiveness of a syngeneic mouse model for medulloblastoma, a type of brain tumor in our laboratory.
In our research, we have conducted extensive screenings of multiple anticancer drug-loaded nanomedicines against this model, leading to significant findings.
Furthermore, we have also conducted screenings of several immune checkpoint inhibitors (PD1, PDL1, CTLA-4, CD47, CD24, CD276) against the MB syngeneic model, resulting in important and promising research outcomes.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
A substantial amount of research-related data has been collected.
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| Strategy for Future Research Activity |
Confirmation of synergistic or combination effect of anticancer drug-loaded nanomedicine and immune checkpoint inhibitors. Additionally, intellectual patent filing and dissemination of results through conference presentation and journal article publication.
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