| Project/Area Number |
22K15143
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 44030:Plant molecular biology and physiology-related
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
ZHANG Ye 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (10899470)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Completed (Fiscal Year 2024)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | regeneration / brassinosteroid / DNA damage / stem cell / plant stem cell / cell division / DNA damage response |
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| Outline of Research at the Start |
Stem cells in the root are less tolerant to DNA damage and would undergo programmed cell death. Afterward cells neighboring to the dead stem cells undergo replenishing divisions to restore the stem cell niche. This study explores brassinosteroid's roles in regulating stem cell regeneration.
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| Outline of Final Research Achievements |
Under DNA stress, stem cells in the root meristem undergo programmed cell death. When released from DNA stress, cells neighboring the dead stem cells are activated to divide to restore the stem cell niche. We found that brassinosteroid (BR) receptor BRL3 is increased through the DNA damage response pathway (Takahashi et al., 2024). The BRL3-dependent BR signaling contributes to the activation of replenishing cell division. Furthermore, this study demonstrated that local wound also increased BR signaling in adjacent cells, signifying the role of BR in tissue regeneration in general.
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| Academic Significance and Societal Importance of the Research Achievements |
This study identified a novel brassinosteroid-mediated pathway regulating tissue regeneration following local cell death. These findings provide new insights into mechanisms of plant healing and may contribute to the development of stress-tolerant, self-repairing crops.
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