Mechanism of malaria-induced disruption of hematopoietic stem cell niche in the bone marrow
Project/Area Number |
22K15448
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 49040:Parasitology-related
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Research Institution | The University of Tokyo |
Principal Investigator |
LEE MICHELLE 東京大学, 医科学研究所, 特任助教 (10821423)
|
Project Period (FY) |
2022-04-01 – 2024-03-31
|
Project Status |
Completed (Fiscal Year 2023)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | lymphopoiesis / hematopoiesis / bone marrow niche / B cell / bone marrow / hematopoietic niche / malaria / Bone marrow / Hematopoiesis / Malaria / Infection |
Outline of Research at the Start |
We previously found that malaria causes bone loss and alters bone marrow hematopoiesis. We recently found changes in bone marrow niches that governs hematopoiesis. This proposal aims to elucidate the molecular mechanisms that contribute to the alteration of bone marrow niches during malaria infection.
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Outline of Annual Research Achievements |
Stresses from infection and inflammation can alter or damage the hematopoietic stem cell (HSC) niches in the bone marrow. CXCL12-abundant reticular (CAR) cells surrounding the sinusoids are the major cellular component of perivascular HSC niches, that are in close contact with HSC and B cell progenitors to support HSC maintenance and lymphopoiesis. We found that malaria infection enhances hematopoiesis but causes an imbalance in the differentiation potential of multipotent progenitor cells. We found that malaria alters CAR cell population and suppresses B lymphopoiesis, as well as the retention of long-lived plasma cells in the bone marrow. This study suggests that malaria has an impact on B cell immunity.
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Report
(2 results)
Research Products
(8 results)