The understanding of early phase of neuropathic pain associated NO and TRPM2

• Project/Area Number: 22K16599
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Niigata University
• Principal Investigator: 大西 毅 新潟大学, 医歯学総合病院, 助教 (60804573)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 神経障害性疼痛 / 一酸化窒素 / TRPM2受容体

Outline of Research at the Start

本研究では神経障害性疼痛の慢性期移行時の作用機序解明を主な目的に，最適な疼痛モデルマウスの作成および低侵襲かつ安価で幅広く行える手法を検討する．また，神経障害性疼痛初期段階の神経型一酸化窒素合成酵素とTRPM2受容体の関連性についても検討し，機序の一端を明らかにしたいと考える．