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Establishment of Data Science Platform for Accelerating Drug Discovery in Emerging Infectious Disease Pandemic

Research Project

Project/Area Number 22K19829
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 62:Applied informatics and related fields
Research InstitutionNagoya University

Principal Investigator

Iwami Shingo  名古屋大学, 理学研究科, 教授 (90518119)

Project Period (FY) 2022-06-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2023: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords数理モデル / データ解析 / 新型コロナウイルス感染症
Outline of Research at the Start

ウイルス感染症では、根本的な原因であるウイルス量の減少、排出期間の短縮が臨床医学上、また、公衆衛生上、極めて重要な役割を果たす。しかし、COVID-19にみられるように、ウイルス排出量・期間は症例毎に大きく異なる。本研究では、定量的なウイルス感染動態の理解に基づいて、以下3つの課題に取り組む:
課題 (1) ウイルス感染動態の定量化と排出期間に基づいた患者層別化技術の確立
課題 (2) 薬物動態/薬力学/ウイルス動態モデルを実装したシミュレータの開発
課題 (3) 抗ウイルス治療効果や排出期間を予測するバイオマーカーの探索技術の確立

Outline of Final Research Achievements

To avoid healthcare collapse during emerging infectious disease outbreaks, establishing standard treatments is crucial. Drug repositioning strongly supports this by identifying existing drugs for new uses. However, the efficacy of approved drugs for emerging infectious diseases may differ due to their mechanism of action and target molecules, making it impossible to directly apply existing administration methods. Thus, there is a need for mathematical information infrastructure to overcome these challenges. This study focuses on interdisciplinary fusion research, emphasizing drug repositioning, which holds the potential to rapidly explore therapeutic options for infectious diseases. We have developed mathematical information infrastructure technology to explosively accelerate the establishment of standard treatments for COVID-19.

Academic Significance and Societal Importance of the Research Achievements

現在、本国と他国との大きな違い・原因の1つに、感染症制御に対する異分野融合研究の経験値の差がある。本研究を実施する過程で、核となる複数大学と研究機関および関係省庁のネットワークが構築され、そして、新興感染症発生時には即座に疫学データ、ゲノムデータ、臨床データが収集・共有・解析され、流行対策や医療体制の構築にフィードバックされる仕組みが準備はじめた。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 Other

All Int'l Joint Research (5 results) Journal Article (10 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results) Book (2 results)

  • [Int'l Joint Research] プギョン大学(韓国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] インディアナ大学(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] USAMRIID(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] プサン大学(韓国)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Analysis of the risk and pre-emptive control of viral outbreaks accounting for within-host dynamics: SARS-CoV-2 as a case study2023

    • Author(s)
      Hart William S.、Park Hyeongki、Jeong Yong Dam、Kim Kwang Su、Yoshimura Raiki、Thompson Robin N.、Iwami Shingo
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 41

    • DOI

      10.1073/pnas.2305451120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution2023

    • Author(s)
      Sunagawa Junya、Park Hyeongki、Kim Kwang Su、Komorizono Ryo、Choi Sooyoun、Ramirez Torres Lucia、Woo Joohyeon、Jeong Yong Dam、Hart William S.、Thompson Robin N.、Aihara Kazuyuki、Iwami Shingo、Yamaguchi Ryo
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 7395-7395

    • DOI

      10.1038/s41467-023-43043-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modeling COVID-19 vaccine booster-elicited antibody response and impact of infection history2023

    • Author(s)
      Nishiyama Takara、Miyamatsu Yuichiro、Park Hyeongki、Nakamura Naotoshi、Yokokawa Shibata Risa、Iwami Shingo、Nagasaki Yoji
    • Journal Title

      Vaccine

      Volume: 41 Issue: 52 Pages: 7655-7662

    • DOI

      10.1016/j.vaccine.2023.11.040

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection2023

    • Author(s)
      Miyamoto S, Nishiyama T et al.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 52 Pages: 1-10

    • DOI

      10.1073/pnas.2314808120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between the inclusion/exclusion criteria and sample size in randomized controlled trials for SARS-CoV-2 entry inhibitors2023

    • Author(s)
      Tatematsu Daiki、Akao Marwa、Park Hyeongki、Iwami Shingo、Ejima Keisuke、Iwanami Shoya
    • Journal Title

      Journal of Theoretical Biology

      Volume: 561 Pages: 111403-111403

    • DOI

      10.1016/j.jtbi.2022.111403

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir2023

    • Author(s)
      Torii Shiho、Kim Kwang Su、Koseki Jun、Suzuki Rigel、Iwanami Shoya、Fujita Yasuhisa、Jeong Yong Dam、Ito Jumpei、Asakura Hiroyuki、Nagashima Mami、Sadamasu Kenji、Yoshimura Kazuhisa、Sato Kei、Matsuura Yoshiharu、Shimamura Teppei、Iwami Shingo、Fukuhara Takasuke、The Genotype to Phenotype Japan (G2P-Japan) Consortium
    • Journal Title

      PLOS Pathogens

      Volume: 19 Issue: 3 Pages: e1011231-e1011231

    • DOI

      10.1371/journal.ppat.1011231

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection.2022

    • Author(s)
      Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson A, Schoggins J, Iwami S, Sato K
    • Journal Title

      PLoS Computational Biology

      Volume: 18 Issue: 4 Pages: 1010053-1010053

    • DOI

      10.1371/journal.pcbi.1010053

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maternal embryonic leucine zipper kinase (MELK) optimally regulates the HIV-1 uncoating process2022

    • Author(s)
      Nishiyama Takara、Takada Toru、Takeuchi Hiroaki、Iwami Shingo
    • Journal Title

      Journal of Theoretical Biology

      Volume: 545 Pages: 111152-111152

    • DOI

      10.1016/j.jtbi.2022.111152

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of timing of infection from longitudinal SARS-CoV-2 viral load data: mathematical modelling study2022

    • Author(s)
      Ejima Keisuke、Kim Kwang Su、Bento Ana I.、Iwanami Shoya、Fujita Yasuhisa、Aihara Kazuyuki、Shibuya Kenji、Iwami Shingo
    • Journal Title

      BMC Infectious Diseases

      Volume: 22 Issue: 1 Pages: 656-656

    • DOI

      10.1186/s12879-022-07646-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Designing isolation guidelines for COVID-19 patients with rapid antigen tests2022

    • Author(s)
      Jeong Yong Dam、Ejima Keisuke、Kim Kwang Su、Joohyeon Woo、Iwanami Shoya、Fujita Yasuhisa、Jung Il Hyo、Aihara Kazuyuki、Shibuya Kenji、Iwami Shingo、Bento Ana I.、Ajelli Marco
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4910-4910

    • DOI

      10.1038/s41467-022-32663-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 新興感染症の異分野融合研究:時系列バイオマーカーのデータサイエンス2023

    • Author(s)
      岩見真吾
    • Organizer
      第97回日本感染症学会総会・学術講演会 第71回日本化学療法学会学術集会 合同学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] A case study of Fukushima vaccination cohort - Real world application (II)2023

    • Author(s)
      Shingo Iwami
    • Organizer
      2023 China-India-Japan-Korea International Conference on Mathematical and Theoretical Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modeling and characterizing vaccine-elicited antibody responses2023

    • Author(s)
      Shingo Iwami
    • Organizer
      ICIAM 2023 TOKYO Computational Biology: Session I
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 急性肝不全の未来予測2023

    • Author(s)
      岩見真吾
    • Organizer
      2023年 日本数理生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ウイルス学におけるデジタルツインアプローチの役割2023

    • Author(s)
      岩見真吾
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 異分野融合アプローチを駆使した創薬DX研究2023

    • Author(s)
      岩見真吾
    • Organizer
      第97回 日本薬理学会年会, 2023/12/15
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Modeling clade I mpox lesion transition dynamics - A retrospective analysis of clinical data in DRC -2023

    • Author(s)
      Shingo Iwami
    • Organizer
      U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] デジタルツイン時代の感染症創薬研究2022

    • Author(s)
      岩見真吾
    • Organizer
      第63回 日本臨床ウイルス学会 シンポジウム4
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] デジタルツイン時代の医薬品の橋渡し研究2022

    • Author(s)
      岩見真吾
    • Organizer
      創薬薬理フォーラム第30回シンポジウム
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 数理モデル駆動型の未病研究 -不均一性と層別化-2022

    • Author(s)
      岩見真吾
    • Organizer
      日本生理学会第100回記念大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Book] 実験医学2023

    • Author(s)
      西山尚来,宮松雄一郎,朴炯基,横川理沙,長崎洋司,岩見真吾
    • Total Pages
      222
    • Publisher
      羊土社
    • Related Report
      2023 Annual Research Report
  • [Book] ウイルス感染の数理モデルとシミュレーション ―データを定量的に理解する―2023

    • Author(s)
      岩見 真吾, 中岡 慎治, 岩波 翔也
    • Total Pages
      304
    • Publisher
      共立出版
    • Related Report
      2023 Annual Research Report

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Published: 2022-07-05   Modified: 2025-01-30  

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