| Project/Area Number |
22KJ1613
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| Project/Area Number (Other) |
22J23828 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 国内 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Nagoya University |
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Principal Investigator |
HUANG Jianhao 名古屋大学, 工学研究科, 特別研究員(DC1)
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| Project Period (FY) |
2023-03-08 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2024: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2023: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2022: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Polyene cyclization / LBA catalyst / asymmetric catalysis / polyene cyclization / LBA catalyst system / asymmetric synthesis |
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| Outline of Research at the Start |
I supposes to design a novel catalysts for the stereoselective polyene cyclization reaction. Inspired by the structure of the bio-enzyme, it may be possible for the design of catalyst candidates. Besides, the screening the optimized catalysts needs vast amounts of experiments and time. Thus, here I would introduce the assistance of quantum chemistry to calculate the best model of the structures and transition states for the interaction between the catalysts and polyene substrates, guide the main direction for the catalysts design and efficiently reduce the volume of experimental screen work.
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| Outline of Annual Research Achievements |
Ｂａｓｅｄ ｏｎ ｔｈｅ ｒｅｓｕｌｔｓ ｆｒｏｍ ｌａｓｔ ｙｅａｒ， ｗｅ ａｒｅ ｃｕｒｒｅｎｔｌｙ ｃｏｎｔｉｎｕｉｎｇ ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ａｎｄ ｅｖａｌｕａｔｅ ｔｈｅ ａｐｐｒｏｐｒｉａｔｅ ｒｅａｃｔｉｏｎ ｃｏｎｄｉｔｉｏｎｓ ｆｏｒ ｉｎｔｒａｍｏｌｅｃｕｌａｒ ｃａｒｂｏｎｙｌ＆＃８２１１；ｅｎｅ ｃｙｃｌｉｚａｔｉｏｎ． Ａｓ ｐｌａｎｎｅｄ ｌａｓｔ ｙｅａｒ， ｉｎｉｔｉａｌｌｙ， ｗｅ ｄｅｖｅｌｏｐｅｄ ａ ｎｏｖｅｌ ｃｌａｓｓ ｏｆ ＢＩＮＯＬ－ｄｅｒｉｖｅｄ ｃｈｉｒａｌ ｐｈｏｓｐｈｏｒｉｃ ａｃｉｄｓ ｗｉｔｈ ｂｉｓ－ａｒｙｌ ｍｅｔｈｙｌ ｓｕｂｓｔｉｔｕｅｎｔｓ ｏｎ ｔｈｅ ３，３＇ ｐｏｓｉｔｉｏｎ ａｓ ｔｈｅ ｆｏｕｎｄａｔｉｏｎ ｏｆ ＬＢＡ ｃａｔａｌｙｓｔｓ ｔｏ ｆａｃｉｌｉｔａｔｅ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ｓｉｎｇｌｅ ｒｉｎｇｓ． Ｂｕｉｌｄｉｎｇ ｏｎ ｔｈｉｓ ｗｏｒｋ， ｗｅ ｈａｖｅ ａｃｈｉｅｖｅｄ ａ ｍｏｄｅｒａｔｅ ｒｅａｃｔｉｏｎ ｙｉｅｌｄ ａｌｏｎｇ ｗｉｔｈ ｍｏｄｅｒａｔｅ ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｉｔｙ ａｎｄ ｅｘｃｅｌｌｅｎｔ Ｅ／Ｚ ｓｅｌｅｃｔｉｖｉｔｙ． Ａｄｄｉｔｉｏｎａｌｌｙ， ｗｅ ａｒｅ ｎｏｗ ｃｏｎｃｅｎｔｒａｔｉｎｇ ｏｎ ｅｘｐａｎｄｉｎｇ ｔｈｅ ｍｅｔｈｏｄｏｌｏｇｙ ｔｏ ｃａｓｃａｄｅ ｃｙｃｌｉｚａｔｉｏｎ．
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Ｔｈｉｓ ｒｅａｃｔｉｏｎ ｐｒｅｓｅｎｔｓ ａ ｓｉｇｎｉｆｉｃａｎｔ ｓｙｎｔｈｅｔｉｃ ｃｈａｌｌｅｎｇｅ ｄｕｅ ｔｏ ｉｔｓ ｄｅｐｅｎｄｅｎｃｅ ｏｎ ｐｒｅｃｉｓｅ ｃｏｎｄｉｔｉｏｎｓ ｆｏｒ ｓｕｃｃｅｓｓｆｕｌ ｅｘｅｃｕｔｉｏｎ． Ｗｅ ｓｐｅｎｔ ａ ｌｏｔ ｏｆ ｔｉｍｅ ｏｎ ａｓｙｍｍｅｔｒｉｃ ｏｐｔｉｍｉｚａｔｉｏｎ ｆｏｒ ｔｈｅ ｒｅａｃｔｉｏｎ ｃｏｎｄｉｔｉｏｎｓ． Ｗｅ ｈａｖｅ ｇｏｎｅ ｔｏ ｇｒｅａｔ ｌｅｎｇｔｈｓ ｔｏ ｓｃｒｅｅｎ ａ ｗｉｄｅ ｖａｒｉｅｔｙ ｏｆ ＢＩＮＯＬ－ｄｅｒｉｖｅｄ ｃｈｉｒａｌ ｐｈｏｓｐｈｏｒｉｃ ａｃｉｄｓ ｂｅａｒｉｎｇ ｄｉｆｆｅｒｅｎｔ ｓｕｂｓｔｉｔｕｅｎｔｓ ｏｎ ｔｈｅｉｒ ３，３’ ｐｏｓｉｔｉｏｎｓ． Ｓｏ ｆａｒ， ｗｅ ｈａｖｅ ａｃｈｉｅｖｅｄ ａ ｍｏｄｅｒａｔｅ ｒｅａｃｔｉｏｎ ｙｉｅｌｄ ａｌｏｎｇ ｗｉｔｈ ｍｏｄｅｒａｔｅ ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｉｔｙ． Ｎｏｗ， ｗｅ ｆｉｎａｌｌｙ ｔｕｒｎ ｏｕｒ ｆｏｃｕｓ ｔｏ ｉｎｖｅｓｔｉｇａｔｉｎｇ ｔｈｅ ｃａｓｃａｄｅ ｃｙｃｌｉｚａｔｉｏｎ ｆｏｒ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ａ ｄｏｕｂｌｅ－ｒｉｎｇ ｓｙｓｔｅｍ ｂａｓｅｄ ｏｎ ｔｈｅ ｏｐｔｉｍｉｚｅｄ ｓｉｎｇｌｅ－ｒｉｎｇ－ｆｏｒｍａｔｉｏｎ ｓｙｓｔｅｍ．
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| Strategy for Future Research Activity |
Ｓｏ ｆａｒ， ｗｅ＇ｖｅ ａｃｈｉｅｖｅｄ ｍｏｄｅｒａｔｅ ｒｅａｃｔｉｏｎ ｙｉｅｌｄ ａｎｄ ｍｏｄｅｒａｔｅ ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｉｔｙ ｉｎ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ｔｈｅ ｓｉｎｇｌｅ－ｒｉｎｇ ｓｙｓｔｅｍ． Ｆｏｒ ｔｈｅ ｒｅｓｅａｒｃｈ ｐｌａｎ ｏｆ ｔｈｅ ｆｏｌｌｏｗｉｎｇ ｙｅａｒ， ｏｎ ｔｈｅ ｏｎｅ ｈａｎｄ， Ｉ ｗｏｕｌｄ ｌｉｋｅ ｔｏ ｐｒｏｍｏｔｅ ｔｈｅ ｒｅｓｅａｒｃｈ ｐｒｏｊｅｃｔ ｏｎ ｔｈｅ ｓｕｂｓｔｒａｔｅ ｓｃｏｐｅ ｆｏｒ ｔｈｉｓ ｓｉｎｇｌｅ－ｒｉｎｇ ｆｏｒｍａｔｉｏｎ． Ｉ ｗｏｕｌｄ ｓｐｅｎｄ ｓｏｍｅ ｔｉｍｅ ｓｙｎｔｈｅｓｉｚｉｎｇ ａｎｄ ｅｘａｍｉｎｉｎｇ ｔｈｅ ｅｆｆｅｃｔ ｏｆ ｓｅｖｅｒａｌ ｓｕｂｓｔｉｔｕｅｎｔｓ ｏｎ ｔｈｅ ｓｔａｎｄａｒｄ ｓｕｂｓｔｒａｔｅ ｕｎｄｅｒ ｔｈｉｓ ｃａｔａｌｙｔｉｃ ｓｙｓｔｅｍ．
Ｏｎ ｔｈｅ ｏｔｈｅｒ ｈａｎｄ， Ｉ ｗｏｕｌｄ ａｌｓｏ ｌｉｋｅ ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｉｓ ｍｅｔｈｏｄｏｌｏｇｙ ｆｏｒ ｃａｓｃａｄｅ ｃｙｃｌｉｚａｔｉｏｎ ｆｏｒ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ｐｏｌｙｐｒｅｎｏｉｄｓ． Ｔｏ ｍｅｅｔ ｔｈｅ ｆｉｎａｌ ｇｏａｌ ｏｆ ｔｈｉｓ ｒｅｓｅａｒｃｈ ｐｒｏｊｅｃｔ， Ｉ ｍａｙ ａｌｓｏ ｆｉｎｅｌｙ ｏｐｔｉｍｉｚｅ ｓｅｖｅｒａｌ ｒｅａｃｔｉｏｎ ｃｏｎｄｉｔｉｏｎｓ ｔｏ ｇｅｔ ｂｅｔｔｅｒ ｒｅｓｕｌｔｓ．
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