| Project/Area Number |
22KJ3082
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| Project/Area Number (Other) |
22J10169 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 国内 |
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| Review Section |
Basic Section 51020:Cognitive and brain science-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
Eltabbal Mohamed 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC2)
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| Project Period (FY) |
2023-03-08 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2023: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2022: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | corticothalmic / tongue / PPC / multisensory / intereception / Corticothalamic |
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| Outline of Research at the Start |
In my research I want to understand the information encoded and computation performed in PPC- LP cortico-thalamic loop during multisensory processing. To do this, I am developing novel behavioral paradigms that depends on intact PPC-LP circuit. I then combine the behavior with intrinsic imaging, two-photon imaging and opto-genetics approaches to infer and analyze the function of the circuit during the behavior.
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| Outline of Annual Research Achievements |
I investigated the role of cortico-thalamic projections from higher order parietal cortex to higher order thalamus during multisensory processing. I did two photon imaging of the soma and apical dendrites of higher order cortex(PPC) corticothalamic layer 6 in behaving mice during multisensory task. I showed that layer 6 corticothalamic somas makes different computation when integrating multisensory signals of different values. I also investigated how these multi-sensory computation are different in the apical dendritic of these corticothalamic cells.
Additionally, I developed a novel behavioral task to study interception-like behavior in head fixed mice. I showed how animals can adaptively change their tongue kinematics during learning. I manipulated the activity of both Crus I/II of the cerebellum and Parietal cortex (PPC) during learning using chemical and chemo-genetics approaches and showed their involvement in interception behavior. I also used one/two photon imaging to investigate these areas involvement in the task.
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