| Co-Investigator(Kenkyū-buntansha) |
ISHII Keizo 東北大学, 大学院工学研究科, 教授 (00134065)
FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
KIKUCHI Yohei 東北大学, 大学院工学研究科, 准教授 (50359535)
MATSUYAMA Shigeo 東北大学, 大学院工学研究科, 准教授 (70219525)
SAKEMI Yasuhiro 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (90251602)
山崎 浩道 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00166654)
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| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
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| Outline of Final Research Achievements |
We performed therapeutic experiments using a murine solid tumor to develop a novel cancer treatment technique for proton therapy combined with a vascular disrupting agent AVE8062. In order to precisely irradiate the tumor with a proton beam, a novel beam monitor based on a micro-pattern gaseous detector was successfully developed and used in the experiments. Treatment effects on tumor growth were evaluated from high spatial resolution PET using [18F]Fluoro-Deoxy-Glucose and [18F]Fluoromisonidazole, and from the tumor-growth-delay measurements. The results show that the single combined-treatment caused extensive necrosis in the inner region of the tumor as well as an additive effect on tumor growth delay. However, tumor cells including hypoxic cells in the tumor periphery survived the single treatment. Therefore, it is suggested that the second proton irradiation combined with AVE8062 is needed to completely kill the tumor cells in the peripheral region of the tumor.
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