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Novel ion-beam therapy technology combined with a vascular disrupting agent based on assessment of treatment effects using a high-resolution PET

Research Project

Project/Area Number 23240077
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

TERAKAWA Atsuki  東北大学, 工学(系)研究科(研究院), 准教授 (10250854)

Co-Investigator(Kenkyū-buntansha) ISHII Keizo  東北大学, 大学院工学研究科, 教授 (00134065)
FURUMOTO Shozo  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
KIKUCHI Yohei  東北大学, 大学院工学研究科, 准教授 (50359535)
MATSUYAMA Shigeo  東北大学, 大学院工学研究科, 准教授 (70219525)
SAKEMI Yasuhiro  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (90251602)
山崎 浩道  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00166654)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Keywords粒子線治療 / 腫瘍血管遮断薬 / 高分解能PET / 腫瘍血流遮断 / 腫瘍血流遮断剤 / 超高分解能PET
Outline of Final Research Achievements

We performed therapeutic experiments using a murine solid tumor to develop a novel cancer treatment technique for proton therapy combined with a vascular disrupting agent AVE8062. In order to precisely irradiate the tumor with a proton beam, a novel beam monitor based on a micro-pattern gaseous detector was successfully developed and used in the experiments. Treatment effects on tumor growth were evaluated from high spatial resolution PET using [18F]Fluoro-Deoxy-Glucose and [18F]Fluoromisonidazole, and from the tumor-growth-delay measurements. The results show that the single combined-treatment caused extensive necrosis in the inner region of the tumor as well as an additive effect on tumor growth delay. However, tumor cells including hypoxic cells in the tumor periphery survived the single treatment. Therefore, it is suggested that the second proton irradiation combined with AVE8062 is needed to completely kill the tumor cells in the peripheral region of the tumor.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] STUDIES ON RADIOACTIVE CESIUM AND ALKALI ELEMENTS IN LENTINULA EDODES (SHIITAKE) BASED ON PIXE ANALYSIS2015

    • Author(s)
      A. Terakawa, K. Ishii, S. Matsuyama et al.
    • Journal Title

      International Journal of PIXE

      Volume: 23 Pages: 147-151

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CONCENTRATION OF CISPLATIN-INCORPORATED POLYMERIC MICELLES IN MURICE SOLID TUMOR EVALUATED USING PIXE ANALYSIS2015

    • Author(s)
      A. Terakawa, K. Ishii, S. Matsuyama et al.
    • Journal Title

      International Journal of PIXE

      Volume: 24

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improvement and recent applications of the Tohoku microbeam system2014

    • Author(s)
      S. Matsuyama, K. Ishii, K. Watanabe, A. Terakawa et al.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 318 Pages: 32-36

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the energy stability of the Tohoku Dynamitron accelerator for microbeam and nanobeam applications2013

    • Author(s)
      S. Matsuyama, M. Fujisawa, T. Nagaya, K. Ishii, A. Terakawa et al.
    • Journal Title

      International Journal of PIXE

      Volume: Vol. 23 Issue: 01n02 Pages: 69-75

    • DOI

      10.1142/s0129083513400081

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍血流遮断により誘発されたマウス固形腫瘍内の元素分布2013

    • Author(s)
      寺川貴樹, 石井慶造、松山成男 他
    • Journal Title

      NMCC共同利用研究成果報文集

      Volume: 19 Pages: 230-235

    • Related Report
      2013 Annual Research Report
  • [Journal Article] IMPROVEMENT OF THE DETECTION EFFICIENCY OF THE IN-AIR SUBMILLI-PIXE CAMERA FOR BIOLOGICAL APPLICATIONS2012

    • Author(s)
      H. Sugai
    • Journal Title

      International Journal of PIXE

      Volume: 22 (1 & 2) Pages: 37-43

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Preliminary Study of Proton Therapy Combined with Cisplatin2012

    • Author(s)
      Terakawa A.
    • Journal Title

      CYRIC Annual Report

      Volume: 2010-2011 Pages: 46-48

    • Related Report
      2012 Annual Research Report
  • [Journal Article] PIXE Analysis of a Murine Fibrosarcoma Tumor Treated With a Vasucular Disrupting Agent AVE80622012

    • Author(s)
      A. Terakawa
    • Journal Title

      CYRIC Annual Report

      Volume: 2010-2011 Pages: 49-51

    • Related Report
      2012 Annual Research Report
  • [Journal Article] PIXE 分析法を用いたマウス固形腫瘍内のシスプラチン含有高分子ミセルの集積評価2012

    • Author(s)
      寺川貴樹
    • Journal Title

      NMCC 共同利用研究成果報文集

      Volume: 18 Pages: 217-221

    • Related Report
      2012 Annual Research Report
  • [Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR TREATED WITH A VASCULAR DISRUPTING AGENT AVE80622011

    • Author(s)
      A.TERAKAWA
    • Journal Title

      International Journal of PIXE

      Volume: Vol.21,Nos.3 & 4 Issue: 03n04 Pages: 125-131

    • DOI

      10.1142/s0129083511002240

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] マイクパターンガス検出器の粒子線治療モニターへの応用2015

    • Author(s)
      佐藤剛、寺川貴樹、石井慶造、松山成男、他
    • Organizer
      日本原子力学会
    • Place of Presentation
      茨城大学、茨城県日立市
    • Year and Date
      2015-03-20 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Three-dimensional image acquisition method by using PIXE analysis2014

    • Author(s)
      S. Matsuyama, A. Terakawa, K. Ishii, S. Matsuyama et al.
    • Organizer
      8th International Symposium on BioPIXE (BioPIXE8)
    • Place of Presentation
      スロベニア、ブレッド市
    • Year and Date
      2014-09-14 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粒子線治療2014

    • Author(s)
      寺川貴樹
    • Organizer
      日本機械学会
    • Place of Presentation
      東京電機大学、東京都足立区
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血流遮断により誘発された腫瘍内元素動態分析へのPIXE法の応用2013

    • Author(s)
      寺川貴樹 石井慶造 松山成男 他
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロパターンガス検出器を用いた2次元粒子プロファイルモニターの開発2013

    • Author(s)
      金田賢 石井慶造 寺川貴樹 松山成男 他
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] PIXE分析を用いた生体試料中の3次元元素分布画像取得法の開発2013

    • Author(s)
      松山哲生 石井慶造 寺川貴樹 松山成男 他
    • Organizer
      第29回PIXEシンポジウム
    • Place of Presentation
      若狭湾エネルギー研究センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Elemental analysis of a murine solid tumor treated with a vascular disrupting agent AVE80622013

    • Author(s)
      A. Terakawa
    • Organizer
      International conference on particle-induced X-ray emission (PIXE 2013)
    • Place of Presentation
      ブラジル
    • Related Report
      2012 Annual Research Report
  • [Presentation] PIXE 分析法を用いたマウス固形腫瘍内のシスプラチン含有高分子ミセルの集積評価2012

    • Author(s)
      寺川貴樹
    • Organizer
      第18回NMCC共同利用研究成果発表会
    • Place of Presentation
      岩手医科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Submilli-PIXE analysis of a murine fibrosarcoma tumor treated with proton therapy combined with cisplatin2011

    • Author(s)
      T.Kawamura
    • Organizer
      Seventh International Symposium on Bio-PIXE
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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