| Budget Amount *help |
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2014: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2011: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Outline of Final Research Achievements |
We conducted the human clinical studies to evaluate postprandial inflammatory responses after fat or glucose intake in healthy subjects. The inflammatory responses and the attenuation of endothelium-dependent vasodilation were observed in postprandial state, which were partly improved by co-intake of fruit derived polyphenol. In cultured cell models, we confirmed the anti-inflammatory effects of polyphenols under the stimulation of fatty acid, glucose or LPS. These results suggest that polyphenols may contribute to improve postprandial inflammatory responses leading to atherosclerosis.
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