Studies on the functional amino acid nutrition and ist application

• Project/Area Number: 23248046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Kyushu University
• Principal Investigator: FURUSE Mitsuhiro 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
• Co-Investigator(Kenkyū-buntansha): TOMONAGA Shozo 九州大学, 大学院農学研究院, 助教 (00552324) ; YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
• Co-Investigator(Renkei-kenkyūsha): YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000); Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
• Keywords: ストレス / トリプトファン / アスパラギン酸 / セリン / チロシン / 不安様行動 / 受容体 / 睡眠 / 脳 / キヌレン酸 / リシン / NMDA受容体 / D型アミノ酸 / うつ / ニワトリ / ピペコリン酸 / モノアミン

Research Abstract

Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor.
Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.

Research Products

• [Journal Article] The metabolism of amino acids differs between the brains of the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii) (2014)
  • Author(s): Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S. and Furuse, M.
  • Journal Title: Springer Plus Volume: (in press)
  • Peer Reviewed
• [Journal Article] Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks (2014)
  • Author(s): Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
  • Journal Title: Life Sciences Volume: (in press)
  • Peer Reviewed
• [Journal Article] Central injection of L-and D-aspartate attenuates isolation induced stress behavior in chicks possibly through different mechanisms (2014)
  • Author(s): Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
  • Journal Title: European Journal of Pharmacology Volume: 736(C) Pages: 138-142
  • DOI: 10.1016/j.ejphar.2014.04.042
  • Peer Reviewed
• [Journal Article] Lauroyl-L-aspartate decreased food intake and body temperature in neonatal chicks (2013)
  • Author(s): Erwan, E., Chowdhury, V. S., Ito, K. and Furuse, M.
  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 113( C) Pages: 7-11
  • DOI: 10.1016/j.pbb.2013.10.010
  • Peer Reviewed
• [Journal Article] Two receptors are involved in the central functions of kynurenic acid under an acute stress in neonatal chicks (2013)
  • Author(s): Yoshida, J., Shigemura, A., Ogino, Y., Denbow, D.M. and Furuse, M.
  • Journal Title: Neuroscience Volume: 248(1) Pages: 194-200
  • DOI: 10.1016/j.neuroscience.2013.06.005
  • Peer Reviewed
• [Journal Article] Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks (2013)
  • Author(s): Erwan, E., Tomonaga, S., Ohmori, T., Mutaguchi, Y., Ohshima, T., Nagasawa, M., Yasuo, S., Tamura, Y., Furuse, M.
  • Journal Title: Journal of Poultry Science Volume: 50 Pages: 164-171
  • NAID: 10031167875
  • Peer Reviewed
• [Journal Article] Orally administered L-tyrosine, but not D-tyrosine, shortly enters into several regions of the mouse brain (2013)
  • Author(s): Takagi, S., Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S., Furuse, M.
  • Journal Title: Journal of Pet Animal Nutrition Volume: 16 Pages: 67-72
  • NAID: 130004951830
  • Peer Reviewed
• [Journal Article] L-DOPA suppressed scratching behavior and modified brain monoamine/amino acid concentrations in mice (2013)
  • Author(s): Akimoto Y, Yasuo S, Furuse M
  • Journal Title: Letters in Drug Design & Discovery Volume: 10 Issue: 3 Pages: 195-203
  • DOI: 10.2174/157018013804999645
  • Peer Reviewed
• [Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats (2012)
  • Author(s): Nagasawa M, Ogino Y, Kurata K, Otsuka T, Yoshida J, Tomonaga S, Furuse M
  • Journal Title: Amino Acids Epub ahead of print Volume: 43(5) Issue: 5 Pages: 2101-2111
  • DOI: 10.1007/s00726-012-1294-y
  • Peer Reviewed
• [Journal Article] Central administration of L-and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks (2012)
  • Author(s): Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Denbow DM, Furuse M.
  • Journal Title: Amino Acids Epub ahead of print Volume: 43(5) Issue: 5 Pages: 1969-1976
  • DOI: 10.1007/s00726-012-1272-4
  • Peer Reviewed
• [Journal Article] Intracerebroventricular injection of kynurenic acid attenuates corticotrophinreleasing hormone-augmented stress responses in neonatal chicks (2012)
  • Author(s): Yoshida, J., Tomonaga, S., Ogino, Y., Nagasawa, M., Kurata, K. and Furuse, M.
  • Journal Title: Neuroscience Volume: 220(1) Pages: 142-148
  • DOI: 10.1016/j.neuroscience.2012.06.041
  • Peer Reviewed
• [Journal Article] Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks (2012)
  • Author(s): Tomonaga S, Kawabata F, Yoshida J, Ogino Y, Tsuji T, Furuse M
  • Journal Title: The Journal of Poultry Science Volume: 49 Issue: 3 Pages: 171-177
  • DOI: 10.2141/jpsa.011143
  • NAID: 130004446370
  • ISSN: 1346-7395, 1349-0486
  • Peer Reviewed
• [Journal Article] Oral administration of L-serine increases L- and D-serine levels in the plasma and brain of fasted rats (2012)
  • Author(s): Tomonaga S, Yamasaki I, Nagasawa M, Ogino Y, Uotsu N, Teramoto S, Furuse M
  • Journal Title: Letters in Drug Design & Discovery Volume: 9 Issue: 7 Pages: 663-667
  • DOI: 10.2174/157018012801319436
  • Peer Reviewed
• [Journal Article] L-Serine decreases taurine concentration in the extracellular fluid of brainslice (2011)
  • Author(s): Shigemi K, Tanaka K, Hayamizu K, Denbow DM, Furuse M
  • Journal Title: Neuroscience & Medicine Volume: 2 Pages: 268-274
  • Peer Reviewed
• [Journal Article] Central administration of L- and D-aspartate attenuates social isolation induced stress behaviors in neonatal chicks
  • Author(s): Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Denbow DM, Furuse M
  • Journal Title: Amino Acids Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats
  • Author(s): Nagasawa M, Ogino Y, Kurata K, Otshika T, Yoshida J, Tomonaga S, Furuse M
  • Journal Title: Amino Acids Volume: (未定)(印刷中)
  • Peer Reviewed
• [Presentation] L-およびD-アスパラギン酸の中枢投与は異なる機構を介して単離ストレス下のヒナのストレス行動を緩和する (2014)
  • Author(s): エディエルワン ,スルチョードリビシュワジット ,長澤麻央 ,五田亮世 ,大塚剛司 ,安尾しのぶ ,古瀬充宏
  • Organizer: 日本家禽学会春季大会
  • Place of Presentation: 筑波大学
  • Year and Date: 2014-03-29
• [Presentation] Wistar Kyotoラットの脳における L-セリン代謝酵素の遺伝子発現解析 (2013)
  • Author(s): 長澤麻央 ,川瀬貴博 ,池田裕美 ,岩本綾香,安尾しのぶ ,古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 熊本大学
  • Year and Date: 2013-11-02
• [Presentation] ジャンガリアンハムスターとロボロフスキーハムスターにおける L-および D-アミノ酸含量の比較に関する研究 (2013)
  • Author(s): 池田裕美 ,川瀬貴博 ,長澤麻央 ,スルチョードリビシュワジット ,安尾しのぶ ,古瀬充宏
  • Organizer: 日本畜産学会第117回大会
  • Place of Presentation: 新潟大学
  • Year and Date: 2013-09-09
• [Presentation] 宿主の脳内D-およびL-アミノ酸代謝に及ぼす腸内細菌叢の影響 (2013)
  • Author(s): 川瀬貴博, 長澤麻央, 安尾 しのぶ, 須藤信行, 古賀泰裕, 古瀬 充宏
  • Organizer: Hindgut Club Japan
  • Place of Presentation: 専修大学
• [Presentation] Wistar Kyotoラットの脳におけるL-セリン代謝酵素の遺伝子発現解析 (2013)
  • Author(s): 長澤麻央, 川瀬貴博, 池田裕美, 岩本綾香, 安尾 しのぶ, 古瀬 充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 熊本市医師会館
• [Presentation] ラットの海馬における神経細胞外液中遊離アミノ酸濃度の日内変動について (2013)
  • Author(s): 川瀬貴博, 長澤麻央, 池田裕美, 安尾 しのぶ, 古瀬 充宏
  • Organizer: 日本畜産学会第117回大会
  • Place of Presentation: 新潟大学
• [Presentation] ジャンガリアンハムスターとロボロフスキーハムスターにおける L-および D-アミノ酸含量の比較に関 する研究 (2013)
  • Author(s): 池田裕美, 川瀬貴博, 長澤麻央, スルチョードリ ビシュワジット, 安尾 しのぶ, 古瀬 充宏
  • Organizer: 日本畜産学会第117回大会
  • Place of Presentation: 新潟大学
• [Presentation] L-セリンの単回および長期給与は Wistar KyotoラットならびにWistarラットにおいて抗うつ様効果を誘導する (2012)
  • Author(s): 長澤麻央・大塚剛司・都合勇希・山長聖和・吉田惇紀・山崎いづみ・魚津伸夫・寺本祐之・安尾しのぶ・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 千葉大学
  • Year and Date: 2012-09-28
• [Presentation] トリプトファン代謝産物の脳室投与が単離ストレス下のニワトリヒナの行動に及ぼす影響 (2012)
  • Author(s): 吉田惇紀・友永省三・荻野ユミ・重村麻子・長澤麻央・古瀬充宏
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2012-03-28
• [Presentation] 鎮静・睡眠作用を有するL-ピペコリン酸は脳内モノアミンならびにアミノ酸代謝に影響を与えない (2012)
  • Author(s): 重村麻子・荻野ユミ・吉田惇紀・長澤麻央・友永省三・古瀬充宏
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2012-03-28
• [Presentation] L-リジン欠乏が哺乳類の概日時計機構に及ぼす影響 (2012)
  • Author(s): 松尾陽香・後藤真梨子・古瀬充宏・安尾しのぶ
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2012-03-28
• [Presentation] L-オルニチンの投与時刻依存的なホルモン分泌リズム制御 (2012)
  • Author(s): 松尾陽香・岩本綾香・大塚剛司・秋月さおり・青木麻実・古瀬充宏・安尾しのぶ
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 千葉大学
• [Presentation] 概日時計に影響を及ぼすアミノ酸の探索 (2012)
  • Author(s): 岩本綾香・河井美里・松尾陽香・古瀬充宏・安尾しのぶ
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 千葉大学
• [Presentation] L-セリンの単回および長期給与はWistar Kyoto ラットならびにWistar ラットにおいて抗うつ様効果を誘導する (2012)
  • Author(s): 長澤麻央・大塚剛司・都合勇希・山長聖和・吉田惇紀・山崎いづみ・魚津伸夫・寺本祐之・安尾しのぶ・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 千葉大学
• [Presentation] Antidepressant-like effects of acute and chronic L-serine treatment in Wistar and Kyoto rats (2012)
  • Author(s): Nagasawa M, Ohtsuka T, Togo Y, Yamanaga M, Yoshida J, Yamasaki I, Uotsu N, Teramoto S, Yasuo S, Furuse M
  • Organizer: International Conference and Exhibition on Nutraceuticals and Functional Foods
  • Place of Presentation: Hawaii, USA
• [Presentation] キノリン酸の脳内投与によるストレス行動の鎮静効果 (2011)
  • Author(s): 友永省三・吉田惇紀・荻野ユミ・古瀬充宏
  • Organizer: 日本トリプトファン研究会
  • Place of Presentation: 東邦大学
  • Year and Date: 2011-12-04
• [Presentation] D-トリプトファンの脳室内投与が単離ストレス下のニワトリヒナに及ぼす影響 (2011)
  • Author(s): 吉田惇紀・友永省三・荻野ユミ・重村麻子・丸田えりか・古瀬充宏
  • Organizer: 日本トリプトファン研究会
  • Place of Presentation: 東邦大学
  • Year and Date: 2011-12-04
• [Presentation] Central administration of L- and D-aspartate attenuates stress behavior in chicks (2011)
  • Author(s): Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Furuse M
  • Organizer: The 8th International AFAS Joint Symposium between Japan and Korea
  • Place of Presentation: 鳥取大学
  • Year and Date: 2011-11-16
• [Presentation] 脳内キヌレン酸が単離ストレス下のニワトリヒナの行動に及ぼす影響 (2011)
  • Author(s): 吉田惇紀・友永省三・荻野ユミ・長澤麻央・倉田幸治・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-11-04
• [Presentation] 脳内グルコースの鎮静・催眠作用におけるアミノ酸の関与解明 (2011)
  • Author(s): 荻野ユミ・友永省三・吉田惇紀・長澤麻央・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-11-04
• [Presentation] L-リジン欠乏がマウスの概日時計に及ぼす影響 (2011)
  • Author(s): 松尾陽香・後藤真理子・古瀬充宏・安尾しのぶ
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-11-04
• [Book] Metabolism and physiology of glutamate in chickens. In: Glutamic Acid: Chemistry, Food Sources and Health Benefits (2013)
  • Author(s): Chowdhury, V.S. and Furuse, M.(Edited by Balcazar, D.M.J. and Perez, E.A.R.)
  • Publisher: NOVA Science Publishers Inc., Hauppauge NY, USA
• [Book] Glutathione Biochemistry Mechanisms of Action and Clinical Implications (2013)
  • Author(s): Furuse M, Denbow DM
  • Total Pages: 20
  • Publisher: NOVA Science Publishers Inc.
• [Book] Glutamic Acid: Chemistry, Food Sources and Health Benefits (2013)
  • Author(s): Chowdhury VS, Furuse M
  • Total Pages: 20
  • Publisher: NOVA Science Publishers Inc.
• [Book] Hormone and Behavior (2013)
  • Author(s): Furuse M, Cline MA, Bungo T, Sugahara K
  • Total Pages: 28
  • Publisher: NOVA Science Publishers Inc.
• [Book] Functions of brain L-aspartate and its derivatives on stress responses. In: Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits (2012)
  • Author(s): Tomonaga, S., Erwan, E., Denbow, D.M. and Furuse, M.(Edited by Jones, J.E. and Morano, D.M.)
  • Publisher: NOVA Science Publishers Inc., Hauppauge NY, USA
• [Book] Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits (2012)
  • Author(s): Tomonaga S, Erwan E, Denbow DM, Furuse M
  • Total Pages: 13
  • Publisher: NOVA Science Publishers Inc.
• [Book] Tyrosine and Aspartic Acid : Properties, Sources and Health Benefits (2012)
  • Author(s): Tomonaga S, Erwan E, Denbow DM, Furuse M
  • Publisher: NOVA Science Publishers Inc.(印刷中)
• [Book] Glutathione Biochemistry Mechanisms of Action and Clinical Implications (2012)
  • Author(s): Furuse M, Denbow DM
  • Publisher: NOVA Science Publishers Inc.(印刷中)
• [Book] Glutamic Acid : Chemistry, Food Sources and Health Benefits (2012)
  • Author(s): Chowdhury VS, Furuse M
  • Publisher: NOVA Science Publishers Inc.(印刷中)
• [Remarks]
  • URL: http://www.agr.kyushu-u.ac.jp/lab/lrmb/
• [Remarks]
  • URL: http://www.agr.kyushu-u.ac.jp/lab/lrmb/