• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the functional amino acid nutrition and ist application

Research Project

Project/Area Number 23248046
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionKyushu University

Principal Investigator

FURUSE Mitsuhiro  九州大学, (連合)農学研究科(研究院), 教授 (30209176)

Co-Investigator(Kenkyū-buntansha) TOMONAGA Shozo  九州大学, 大学院農学研究院, 助教 (00552324)
YASUO Shinobu  九州大学, 大学院農学研究院, 准教授 (30574719)
Co-Investigator(Renkei-kenkyūsha) YASUO Shinobu  九州大学, 大学院農学研究院, 准教授 (30574719)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Keywordsストレス / トリプトファン / アスパラギン酸 / セリン / チロシン / 不安様行動 / 受容体 / 睡眠 / 脳 / キヌレン酸 / リシン / NMDA受容体 / D型アミノ酸 / うつ / ニワトリ / ピペコリン酸 / モノアミン
Research Abstract

Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor.
Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (48 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (21 results) Book (9 results) Remarks (2 results)

  • [Journal Article] The metabolism of amino acids differs between the brains of the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii)2014

    • Author(s)
      Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S. and Furuse, M.
    • Journal Title

      Springer Plus

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks2014

    • Author(s)
      Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
    • Journal Title

      Life Sciences

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central injection of L-and D-aspartate attenuates isolation induced stress behavior in chicks possibly through different mechanisms2014

    • Author(s)
      Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
    • Journal Title

      European Journal of Pharmacology

      Volume: 736(C) Pages: 138-142

    • DOI

      10.1016/j.ejphar.2014.04.042

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lauroyl-L-aspartate decreased food intake and body temperature in neonatal chicks2013

    • Author(s)
      Erwan, E., Chowdhury, V. S., Ito, K. and Furuse, M.
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 113( C) Pages: 7-11

    • DOI

      10.1016/j.pbb.2013.10.010

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two receptors are involved in the central functions of kynurenic acid under an acute stress in neonatal chicks2013

    • Author(s)
      Yoshida, J., Shigemura, A., Ogino, Y., Denbow, D.M. and Furuse, M.
    • Journal Title

      Neuroscience

      Volume: 248(1) Pages: 194-200

    • DOI

      10.1016/j.neuroscience.2013.06.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks2013

    • Author(s)
      Erwan, E., Tomonaga, S., Ohmori, T., Mutaguchi, Y., Ohshima, T., Nagasawa, M., Yasuo, S., Tamura, Y., Furuse, M.
    • Journal Title

      Journal of Poultry Science

      Volume: 50 Pages: 164-171

    • NAID

      10031167875

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orally administered L-tyrosine, but not D-tyrosine, shortly enters into several regions of the mouse brain2013

    • Author(s)
      Takagi, S., Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S., Furuse, M.
    • Journal Title

      Journal of Pet Animal Nutrition

      Volume: 16 Pages: 67-72

    • NAID

      130004951830

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-DOPA suppressed scratching behavior and modified brain monoamine/amino acid concentrations in mice2013

    • Author(s)
      Akimoto Y, Yasuo S, Furuse M
    • Journal Title

      Letters in Drug Design & Discovery

      Volume: 10 Issue: 3 Pages: 195-203

    • DOI

      10.2174/157018013804999645

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats2012

    • Author(s)
      Nagasawa M, Ogino Y, Kurata K, Otsuka T, Yoshida J, Tomonaga S, Furuse M
    • Journal Title

      Amino Acids Epub ahead of print

      Volume: 43(5) Issue: 5 Pages: 2101-2111

    • DOI

      10.1007/s00726-012-1294-y

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central administration of L-and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks2012

    • Author(s)
      Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Denbow DM, Furuse M.
    • Journal Title

      Amino Acids Epub ahead of print

      Volume: 43(5) Issue: 5 Pages: 1969-1976

    • DOI

      10.1007/s00726-012-1272-4

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebroventricular injection of kynurenic acid attenuates corticotrophinreleasing hormone-augmented stress responses in neonatal chicks2012

    • Author(s)
      Yoshida, J., Tomonaga, S., Ogino, Y., Nagasawa, M., Kurata, K. and Furuse, M.
    • Journal Title

      Neuroscience

      Volume: 220(1) Pages: 142-148

    • DOI

      10.1016/j.neuroscience.2012.06.041

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks2012

    • Author(s)
      Tomonaga S, Kawabata F, Yoshida J, Ogino Y, Tsuji T, Furuse M
    • Journal Title

      The Journal of Poultry Science

      Volume: 49 Issue: 3 Pages: 171-177

    • DOI

      10.2141/jpsa.011143

    • NAID

      130004446370

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of L-serine increases L- and D-serine levels in the plasma and brain of fasted rats2012

    • Author(s)
      Tomonaga S, Yamasaki I, Nagasawa M, Ogino Y, Uotsu N, Teramoto S, Furuse M
    • Journal Title

      Letters in Drug Design & Discovery

      Volume: 9 Issue: 7 Pages: 663-667

    • DOI

      10.2174/157018012801319436

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-Serine decreases taurine concentration in the extracellular fluid of brainslice2011

    • Author(s)
      Shigemi K, Tanaka K, Hayamizu K, Denbow DM, Furuse M
    • Journal Title

      Neuroscience & Medicine

      Volume: 2 Pages: 268-274

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central administration of L- and D-aspartate attenuates social isolation induced stress behaviors in neonatal chicks

    • Author(s)
      Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Denbow DM, Furuse M
    • Journal Title

      Amino Acids

      Volume: (未定)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats

    • Author(s)
      Nagasawa M, Ogino Y, Kurata K, Otshika T, Yoshida J, Tomonaga S, Furuse M
    • Journal Title

      Amino Acids

      Volume: (未定)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] L-およびD-アスパラギン酸の中枢投与は異なる機構を介して単離ストレス下のヒナのストレス行動を緩和する2014

    • Author(s)
      エディエルワン ,スルチョードリビシュワジット ,長澤麻央 ,五田亮世 ,大塚剛司 ,安尾しのぶ ,古瀬充宏
    • Organizer
      日本家禽学会春季大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2014-03-29
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Wistar Kyotoラットの脳における L-セリン代謝酵素の遺伝子発現解析2013

    • Author(s)
      長澤麻央 ,川瀬貴博 ,池田裕美 ,岩本綾香,安尾しのぶ ,古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      熊本大学
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] ジャンガリアンハムスターとロボロフスキーハムスターにおける L-および D-アミノ酸含量の比較に関する研究2013

    • Author(s)
      池田裕美 ,川瀬貴博 ,長澤麻央 ,スルチョードリビシュワジット ,安尾しのぶ ,古瀬充宏
    • Organizer
      日本畜産学会第117回大会
    • Place of Presentation
      新潟大学
    • Year and Date
      2013-09-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 宿主の脳内D-およびL-アミノ酸代謝に及ぼす腸内細菌叢の影響2013

    • Author(s)
      川瀬貴博, 長澤麻央, 安尾 しのぶ, 須藤信行, 古賀泰裕, 古瀬 充宏
    • Organizer
      Hindgut Club Japan
    • Place of Presentation
      専修大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wistar Kyotoラットの脳におけるL-セリン代謝酵素の遺伝子発現解析2013

    • Author(s)
      長澤麻央, 川瀬貴博, 池田裕美, 岩本綾香, 安尾 しのぶ, 古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      熊本市医師会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットの海馬における神経細胞外液中遊離アミノ酸濃度の日内変動について2013

    • Author(s)
      川瀬貴博, 長澤麻央, 池田裕美, 安尾 しのぶ, 古瀬 充宏
    • Organizer
      日本畜産学会第117回大会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ジャンガリアンハムスターとロボロフスキーハムスターにおける L-および D-アミノ酸含量の比較に関 する研究2013

    • Author(s)
      池田裕美, 川瀬貴博, 長澤麻央, スルチョードリ ビシュワジット, 安尾 しのぶ, 古瀬 充宏
    • Organizer
      日本畜産学会第117回大会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] L-セリンの単回および長期給与は Wistar KyotoラットならびにWistarラットにおいて抗うつ様効果を誘導する2012

    • Author(s)
      長澤麻央・大塚剛司・都合勇希・山長聖和・吉田惇紀・山崎いづみ・魚津伸夫・寺本祐之・安尾しのぶ・古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      千葉大学
    • Year and Date
      2012-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] トリプトファン代謝産物の脳室投与が単離ストレス下のニワトリヒナの行動に及ぼす影響2012

    • Author(s)
      吉田惇紀・友永省三・荻野ユミ・重村麻子・長澤麻央・古瀬充宏
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 鎮静・睡眠作用を有するL-ピペコリン酸は脳内モノアミンならびにアミノ酸代謝に影響を与えない2012

    • Author(s)
      重村麻子・荻野ユミ・吉田惇紀・長澤麻央・友永省三・古瀬充宏
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] L-リジン欠乏が哺乳類の概日時計機構に及ぼす影響2012

    • Author(s)
      松尾陽香・後藤真梨子・古瀬充宏・安尾しのぶ
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] L-オルニチンの投与時刻依存的なホルモン分泌リズム制御2012

    • Author(s)
      松尾陽香・岩本綾香・大塚剛司・秋月さおり・青木麻実・古瀬充宏・安尾しのぶ
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      千葉大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 概日時計に影響を及ぼすアミノ酸の探索2012

    • Author(s)
      岩本綾香・河井美里・松尾陽香・古瀬充宏・安尾しのぶ
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      千葉大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] L-セリンの単回および長期給与はWistar Kyoto ラットならびにWistar ラットにおいて抗うつ様効果を誘導する2012

    • Author(s)
      長澤麻央・大塚剛司・都合勇希・山長聖和・吉田惇紀・山崎いづみ・魚津伸夫・寺本祐之・安尾しのぶ・古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      千葉大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Antidepressant-like effects of acute and chronic L-serine treatment in Wistar and Kyoto rats2012

    • Author(s)
      Nagasawa M, Ohtsuka T, Togo Y, Yamanaga M, Yoshida J, Yamasaki I, Uotsu N, Teramoto S, Yasuo S, Furuse M
    • Organizer
      International Conference and Exhibition on Nutraceuticals and Functional Foods
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] キノリン酸の脳内投与によるストレス行動の鎮静効果2011

    • Author(s)
      友永省三・吉田惇紀・荻野ユミ・古瀬充宏
    • Organizer
      日本トリプトファン研究会
    • Place of Presentation
      東邦大学
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-トリプトファンの脳室内投与が単離ストレス下のニワトリヒナに及ぼす影響2011

    • Author(s)
      吉田惇紀・友永省三・荻野ユミ・重村麻子・丸田えりか・古瀬充宏
    • Organizer
      日本トリプトファン研究会
    • Place of Presentation
      東邦大学
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central administration of L- and D-aspartate attenuates stress behavior in chicks2011

    • Author(s)
      Erwan E, Tomonaga S, Yoshida J, Nagasawa M, Ogino Y, Furuse M
    • Organizer
      The 8th International AFAS Joint Symposium between Japan and Korea
    • Place of Presentation
      鳥取大学
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳内キヌレン酸が単離ストレス下のニワトリヒナの行動に及ぼす影響2011

    • Author(s)
      吉田惇紀・友永省三・荻野ユミ・長澤麻央・倉田幸治・古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2011-11-04
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 脳内グルコースの鎮静・催眠作用におけるアミノ酸の関与解明2011

    • Author(s)
      荻野ユミ・友永省三・吉田惇紀・長澤麻央・古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] L-リジン欠乏がマウスの概日時計に及ぼす影響2011

    • Author(s)
      松尾陽香・後藤真理子・古瀬充宏・安尾しのぶ
    • Organizer
      日本アミノ酸学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Book] Metabolism and physiology of glutamate in chickens. In: Glutamic Acid: Chemistry, Food Sources and Health Benefits2013

    • Author(s)
      Chowdhury, V.S. and Furuse, M.(Edited by Balcazar, D.M.J. and Perez, E.A.R.)
    • Publisher
      NOVA Science Publishers Inc., Hauppauge NY, USA
    • Related Report
      2013 Final Research Report
  • [Book] Glutathione Biochemistry Mechanisms of Action and Clinical Implications2013

    • Author(s)
      Furuse M, Denbow DM
    • Total Pages
      20
    • Publisher
      NOVA Science Publishers Inc.
    • Related Report
      2012 Annual Research Report
  • [Book] Glutamic Acid: Chemistry, Food Sources and Health Benefits2013

    • Author(s)
      Chowdhury VS, Furuse M
    • Total Pages
      20
    • Publisher
      NOVA Science Publishers Inc.
    • Related Report
      2012 Annual Research Report
  • [Book] Hormone and Behavior2013

    • Author(s)
      Furuse M, Cline MA, Bungo T, Sugahara K
    • Total Pages
      28
    • Publisher
      NOVA Science Publishers Inc.
    • Related Report
      2012 Annual Research Report
  • [Book] Functions of brain L-aspartate and its derivatives on stress responses. In: Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits2012

    • Author(s)
      Tomonaga, S., Erwan, E., Denbow, D.M. and Furuse, M.(Edited by Jones, J.E. and Morano, D.M.)
    • Publisher
      NOVA Science Publishers Inc., Hauppauge NY, USA
    • Related Report
      2013 Final Research Report
  • [Book] Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits2012

    • Author(s)
      Tomonaga S, Erwan E, Denbow DM, Furuse M
    • Total Pages
      13
    • Publisher
      NOVA Science Publishers Inc.
    • Related Report
      2012 Annual Research Report
  • [Book] Tyrosine and Aspartic Acid : Properties, Sources and Health Benefits2012

    • Author(s)
      Tomonaga S, Erwan E, Denbow DM, Furuse M
    • Publisher
      NOVA Science Publishers Inc.(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Glutathione Biochemistry Mechanisms of Action and Clinical Implications2012

    • Author(s)
      Furuse M, Denbow DM
    • Publisher
      NOVA Science Publishers Inc.(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Glutamic Acid : Chemistry, Food Sources and Health Benefits2012

    • Author(s)
      Chowdhury VS, Furuse M
    • Publisher
      NOVA Science Publishers Inc.(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.agr.kyushu-u.ac.jp/lab/lrmb/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.agr.kyushu-u.ac.jp/lab/lrmb/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi