Establishment of control measure for bovine leukemia based on risk analysis of virus transmission
| Project/Area Number |
23248051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KONNAI SATORU 北海道大学, (連合)獣医学研究科, 准教授 (40396304)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Kazuhiko 北海道大学, 大学院獣医学研究科, 教授 (90250498)
MURATA Shiro 北海道大学, 大学院獣医学研究科, 助教 (10579163)
田島 誉士 北海道大学, 大学院・獣医学研究科, 准教授 (90202168)
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| Project Period (FY) |
2011-11-18 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 牛白血病 / 牛白血病ウイルス / 伝播リスク / ウイルス定量 / 清浄化モデル / プロウイルス / リンパ球数 / 免疫抑制 |
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| Outline of Final Research Achievements |
Bovine leukaemia virus (BLV) causes enzootic bovine leukosis (EBL) in cattle and represents a serious problem in Japanese meat and dairy industries. In this study, BLV from newly infected cattle was characterized to determine the virus source in a herd and a vector control measure was used to prevent the spread of the infection. The env sequences from positive conversion cattle showed 100% nucleotide identity with the sequence from the PL cattle with high provirus, suggesting that animals may serve as a reservoir of BLV infection. In the farms, where many blood-feeding stable flies were observed, vector control performed using a combination of insect repellents was very efficient as no new cases of BLV infection were observed after the treatment. This study indicates that BLV-infected cattle with high virus is one of high risk factors for the transmission, and vector-borne transmission might have been the major transmission route in the farm.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus2013
Author(s)
Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S., Ohashi K.
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Journal Title
Comp Immunol Microbiol Infect Dis.
Volume: 36
Issue: 1
Pages: 63-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection2012
Author(s)
Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K.
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Journal Title
Vet. Res.
Volume: 43
Issue: 1
Pages: 45-45
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular detection of Anaplasma phagocytophilum in cattle and Ixodes persulcatus ticks2011
Author(s)
Murase Y, Konnai S, Hidano A, Githaka W.N, Ito T, Takano A, Kawabata H, Ato M, Tajima T, Tajima M, Onuma M, Murata S, Ohashi K
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Journal Title
Vet.Microbiol.
Volume: 49
Issue: 3-4
Pages: 504-507
DOI
Related Report
Peer Reviewed
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