| Project/Area Number |
23248051
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical veterinary science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KONNAI SATORU 北海道大学, (連合)獣医学研究科, 准教授 (40396304)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHASHI Kazuhiko 北海道大学, 大学院獣医学研究科, 教授 (90250498)
MURATA Shiro 北海道大学, 大学院獣医学研究科, 助教 (10579163)
田島 誉士 北海道大学, 大学院・獣医学研究科, 准教授 (90202168)
|
|---|
| Project Period (FY) |
2011-11-18 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
|---|
| Keywords | 牛白血病 / 牛白血病ウイルス / 伝播リスク / ウイルス定量 / 清浄化モデル / プロウイルス / リンパ球数 / 免疫抑制 |
|---|
| Outline of Final Research Achievements |
Bovine leukaemia virus (BLV) causes enzootic bovine leukosis (EBL) in cattle and represents a serious problem in Japanese meat and dairy industries. In this study, BLV from newly infected cattle was characterized to determine the virus source in a herd and a vector control measure was used to prevent the spread of the infection. The env sequences from positive conversion cattle showed 100% nucleotide identity with the sequence from the PL cattle with high provirus, suggesting that animals may serve as a reservoir of BLV infection. In the farms, where many blood-feeding stable flies were observed, vector control performed using a combination of insect repellents was very efficient as no new cases of BLV infection were observed after the treatment. This study indicates that BLV-infected cattle with high virus is one of high risk factors for the transmission, and vector-borne transmission might have been the major transmission route in the farm.
|
