| Project/Area Number |
23249037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyushu University |
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Principal Investigator |
Iwase Masanori 九州大学, 医学(系)研究科(研究院), 研究員 (00203381)
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| Co-Investigator(Kenkyū-buntansha) |
KITAZONO Takanari 九州大学, 医学研究院, 教授 (70284487)
KUBO Michiaki 理化学研究所, ゲノム医科学研究センター, センター長代行 (30442958)
KIYOHARA Yutaka 九州大学, 医学研究院, 教授 (80161602)
KANG Dongchon 九州大学, 医学研究院, 教授 (80214716)
OHKUMA Toshiaki 九州大学, 医学研究院, 助教 (20709258)
DOI Yasufumi 麻生飯塚病院, 医務室 (00419566)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Satoshi 東京大学, 医学系研究科, 教授 (70275121)
KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | コホート研究 / 生活習慣病 / 低血糖 / 慢性腎臓病 / 睡眠 / 一塩基多型 / 肥満 / 遺伝子－環境相互作用 / 糖尿病 / 疫学 / 生活習慣 / ゲノム疫学 / 心血管病 / 遺伝環境相互作用 / 身体活動量 / 食事調査 / うつ / 断面調査 / うつ症状 / 栄養調査 / 高血圧 / 遺伝子多型 / 前向き研究 |
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| Outline of Final Research Achievements |
Diabetes mellitus is rapidly epidemic in Japan, although its effective treatment remains to be established. Since the goal of treatment is to approximate the prognosis of diabetic patients to that of healthy subjects as close as possible, the prospective study to compare diabetic and nondiabetic subjects should be mandatory.
The database has been developed comprising 5,131 diabetic patients (The Fukuoka Diabetes Registry, follow-up period 5 years, follow-up rate 97%) and 3,351 community-dwelling residents including those with normal glucose tolerance (The Hisayama Study). We have investigated the lifestyle such as the speed of eating, intakes of dietary fiber and magnesium, physical activity, alcohol consumption, smoking, sleeping time, depressive symptoms and the accumulation of lifestyle risks, islet autoantibody in type 2 diabetic patients, genetic variants susceptible to type 2 diabetes, severe hypoglycemia, chronic kidney disease, cancer, and gene-environment interactions.
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