Host and parasite genetic factors that influence the reactivity to Benznidazol treatment of the peadiatric chronic Chagas patients in Bolivia
| Project/Area Number |
23256003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
HIRAYAMA Kenji 長崎大学, 熱帯医学研究所, 教授 (60189868)
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| Co-Investigator(Kenkyū-buntansha) |
NARA Takeshi 順天堂大学, 大学院医学研究科, 准教授 (40276473)
NGUYEN Huytien 長崎大学, 熱帯医学研究所, 准教授 (20457526)
KIKUCHI Mihoko 長崎大学, 熱帯医学研究所, 講師 (40336186)
柳 哲雄 長崎大学, 熱帯医学研究所, 助手 (10174541)
三浦 左千夫 慶応義塾大学, 医学部, 助教 (30051858)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEMURA Koji 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2013: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2012: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
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| Keywords | シャーガス病 / ボリビア / ベンズニダゾール / 治療効果 / 遺伝子多型解析 |
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| Outline of Final Research Achievements |
In collaboration with the governmental Chagas control program in Bolivia, one year longitudinal hospital cohort study was performed to assess the host genetic factors on the reactivity to 2 months regimen of Benznidazol for the 77 peadiatric chagas patients. The clinical records and laboratory data including specific antibody titer, parasite qPCR, plasma levels of BNZ and cytokines were monitored and used for the evaluation of their reactivity to the treatment. They were divided into three groups 1)effective, 2)less effective, 3)side effect. Host DNA were analyzed for the HLA, P-450 enzymes, genes polymorphism to see their influence on the reactivity to BNZ.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Immunogenetic analysis of chronic Chagas disease in Bolivia2011
Author(s)
F del Puerto Rodas, J E Nishizawa, M Kikuchi, N Iihoshi, Y Raca, C Avilas, A G, J Lora, F U.G.Velarde, L A.Renjel, S Miura, H Higo, N Komita, K Maemura, M Yasunami, K Hirayama
Organizer
第20回日本組織適合性学会大会
Place of Presentation
ツインメッセ静岡、静岡
Related Report
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