Study on neuronal mechanisms for negative emotion using behavioral and optogenetical analyses
| Project/Area Number |
23300130
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAMI Masabumi 北海道大学, 薬学研究科(研究院), 教授 (20243040)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEDA Katsuyuki 北海道大学, 大学院・薬学研究院, 准教授 (30421366)
IDE Soichiro 北海道大学, 大学院・薬学研究院, 助教 (30389118)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 情動 / 疼痛 / 抑うつ / 不安 / 神経ペプチド / 行動薬理 / 神経路特異的 / オプトジェネティクス / ノルアドレナリン / 行動薬理学 |
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| Research Abstract |
Behavioral studies revealed the opposing roles of corticotropin-releasing factor (CRF) and neuropeptide Y (NPY) within the bed nucleus of the stria terminalis (BNST) in the negative affective component of pain in rats. Electrophysiological studies demonstrated that CRF and NPY selectively act on BNST type II neurons, and activates and suppresses these neurons, respectively. Histochemical analyses showed that most of BNST output neurons projecting to the VTA are GABAergic neurons, which synapse onto VTA GABAergic neurons, suggesting the excitatory drive from the BNST to the VTA dopaminergic neurons via a disinhibition mechanism. Pain-induced release of CRF within the BNST may activate BNST type II neurons, which could suppress VTA-projecting BNST output neurons, thereby attenuating the excitatory drive to the VTA dopaminergic neurons. Pain-induced negative emotion may be due to the suppression of VTA dopaminergic neurons via the processing of pain information in the BNST.
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Report
(4 results)
Research Products
(48 results)
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[Presentation] 痛みによる不快情動生成における背外側分界条床核内コルチコトロピン放出因子とニューロペプチドY 神経情報伝達の相反的役割2013
Author(s)
圓山智嘉史, 井手聡一郎, 原大樹, 大野篤志, 玉野竜太, 小関加奈, 中誠則, 出山諭司, 金田勝幸, 吉岡充弘, 南雅文
Organizer
次世代を担う創薬・医療薬理シンポジウム2013
Place of Presentation
熊本
Year and Date
2013-08-31
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[Presentation] 痛みによる不快情動生成における背外側分界条床核内コルチコトロピン放出因子の関与役割2012
Author(s)
小関加奈, 原大樹, 井手聡一郎, 大野篤志, 玉野竜太, 圓山智嘉史, 中誠則, 出山諭司, 金田勝幸, 吉岡充弘, 南雅文
Organizer
次世代を担う創薬・医療薬理シンポジウム
Place of Presentation
神戸
Year and Date
2012-09-01
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