| Budget Amount *help |
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Outline of Final Research Achievements |
We have developed a novel brain injury model designated "photo-injury", which shows substantial cortical tissue regeneration. Further histological analysis showed a robust accumulation of nestin-expressing reactive astrocyte in the regenerating region. Since the genetic modification of the accumulation of the reactive astrocyte caused significant alteration of cortical regeneration, these cells were indicated to play a pivotal role in regeneration. Meanwhile, the majority of the reactive astrocyte was ablated during wound healing in our fate mapping study. These results suggest the nestin-expressing reactive astrocyte is one of the determinant of the process brain lesion and a potent diagnostic as well as therapeutic target of brain injury.
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