Mechanism of pleiotropic effects of exercise training in inter-organ communication

• Project/Area Number: 23300196
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: OSAMU Ito 東北大学, 医学(系)研究科(研究院), 准教授 (00361072)
• Co-Investigator(Kenkyū-buntansha): MORI Nobuyoshi 東北大学, 大学院・医学系研究科, 助教 (50463790) ; KOHZUKI Masahiro 東北大学, 大学院・医学系研究科, 教授 (70234698)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: リハビリテーション / 臓器連関 / 腎臓 / 循環器・高血圧 / 酸化ストレス / 組織・細胞 / 動物

Research Abstract

The impacts of inhibitors of NADPH oxidase and xanthine oxidase in the exercise training (Ex)-increased nitric oxide (NO) synthase (NOS) activity and expression were examined in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs). Ex-increased NOS activity and expression in aorta were mediated through NADPH oxidase in both SHRs and WKYs. The Ex-induced NOS activity and expression in kidney were mediated through NADPH oxidase in WKYs but through xanthine oxidase in SHRs.
In Dahl salt-sensitive rats, Ex improves high salt-induced renal damage in the blood pressure-independent manner with changes of oxidative stress, NO system, renin-angiotensin system, and arachidonic acid metabolism in the kidney.

Research Products

• [Journal Article] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure (2013)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Journal Title: Clin Exp Pharma Physiol Volume: 40 Pages: 617-625
  • Peer Reviewed
• [Journal Article] Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats (2013)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda T, Muroya Y, Takashima K, Ito S, Kohzuki M
  • Journal Title: Clin Exp Pharma Physiol Volume: 4 Pages: 74-82
  • Peer Reviewed
• [Journal Article] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure (2013)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Journal Title: Clin Exp Pharma Physioll Volume: 40 Pages: 617-625
  • Peer Reviewed
• [Journal Article] Renal rehabilitation in patients with chronic kidney disease (2013)
  • Author(s): Kohzuki M, Sakata Y, Mori N, Ebihara S, Ito O
  • Journal Title: Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 7 Pages: 5-6
• [Journal Article] The present situation of PhaseII cardiac rehabilitation for acute myocardial infarction at clinics in Japan (2013)
  • Author(s): Sakata Y, Ito O, Watanabe H, Kohzuki M
  • Journal Title: Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 7 Pages: 143-14
• [Journal Article] Effect of cardiac rehabilitation on exercise tolerance, instrumental activities of daily living (IADL) and Quality of Life (QOL) in severe heart failure treated with implantable left ventricular assist device (LVAD) (2013)
  • Author(s): Suzuki F, Ito O, Mori N, Takahashi T, Sakata Y, Nagasaka M, Ebihara S, Nakatomi C, Minamishima D, Nikkuni Y, Akiyama M, Kawamoto S, Saiki Y, Kohzuki M
  • Journal Title: Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 7 Pages: 141-142
• [Journal Article] Effect of exercise training for intermittent claudication due to incomplete persistent sciatic artery (2013)
  • Author(s): Kakihana T, Ito O, Suzuki F, Kohzuki M
  • Journal Title: Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 7 Pages: 202-203
• [Journal Article] 植込み型補助人工心臓（LVAD）を装着した重症心不全への心臓リハビリテーションの効果 (2013)
  • Author(s): 鈴木文歌, 伊藤 修, 森 信芳, 高橋珠緒，坂田佳子，長坂 誠，海老原覚, 仲冨千瑞, 南島大輔, 新國悦弘, 秋山正年, 川本俊介, 齋木佳克, 上月正博
  • Journal Title: 運動器リハビリテーション Volume: 24 Pages: 65-71
  • NAID: 10031181298
  • Peer Reviewed
• [Journal Article] A paradigm shift in rehabilitation Medicine : From "adding life to years" to "adding life to years and years to life" (2012)
  • Author(s): Kohzuki M, Sakata Y, Kawamura T, Ebihara S, Ito O
  • Journal Title: Asian Journal of Human Services Volume: 2 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Disorders of fatty acid metabolism in the kidney of puromycin aminonucleosideinduced nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Rong R, Takashima K, Ito D, Cao P, Nakamura Y, Joh K, Kohzuki M
  • Journal Title: Am J Physiol Renal Physiol Volume: 303
  • Peer Reviewed
• [Journal Article] PAN ネフローゼラットにおける腎内脂肪酸代謝異常に対するclofibrate とvalsartanの治療効果 (2012)
  • Author(s): 室谷嘉一, 伊藤 修, 戎 栄, 高島健太, 曹 鵬宇, 伊藤大亮, 上月正博
  • Journal Title: Therapeutic Research Volume: 33 Pages: 170-172
  • Peer Reviewed
• [Journal Article] Disorders of fatty acid metabolism in the kidney of PAN-induced nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Ron R, Takashima K, Ito D, Cao P, Nakamura Y, Joh K, Kohzuki M
  • Journal Title: Am J Physiol Renal Physiol Volume: 303
  • Peer Reviewed
• [Journal Article] PANネフローゼラットにおける腎内脂肪酸代謝異常に対するclofibrateとvalsartanの治療効果 (2012)
  • Author(s): 室谷嘉一，伊藤 修，戎 栄, 高島健太，曹 鵬宇, 伊藤大亮，上月正博
  • Journal Title: Therapeutic Research Volume: 33 Pages: 170-172
  • Peer Reviewed
• [Journal Article] Exercise training decreases the enhanced expression of soluble (pro)renin receptor in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Rong R, Ito O, Mori N, Cao P, Kohzuki M
  • Journal Title: Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine Pages: 40-41
• [Journal Article] Effects of exercise training on the expression of angiotensin-converting enzyme in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Sakuyama A, Ito O, Cao P, Rong R, Ito D, Kohzuki M
  • Journal Title: Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine Pages: 143-144
• [Journal Article] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果 (2011)
  • Author(s): 須田千尋, 金澤雅之, 姚 強, 高島健太, 坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
  • Journal Title: 運動療法と物理療法 Volume: 22 Pages: 78-84
  • NAID: 10029055151
  • Peer Reviewed
• [Journal Article] Endogenous hydrogen peroxide upregulates the expression of nitric oxide synthases in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Cao P, Ito O, Guo Q, Ito D, Muroya Y, Rons R, Mori T, Ito S, Kohzuki M
  • Journal Title: Journal of Hypertension Volume: 29 Pages: 1167-1174
  • Peer Reviewed
• [Journal Article] Effects of exercise training on the expression of angiotensin-converting enzyme in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Sakuyama A, Ito O, Cao P, Ron R, Ito D, Kohzuki M
  • Journal Title: Proceedings of the 6th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 1 Pages: 143-144
• [Presentation] 腎不全への運動療法 : 基礎的な検討から (2014)
  • Author(s): 伊藤 修, 上月正博
  • Organizer: 第4回日本腎臓リハビリテーション学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-03-29
• [Presentation] Dahl 食塩感受性ラットにおける長期的運動の腎保護作用-酸化ストレスとNOの観点から (2014)
  • Author(s): 坂田佳子, 伊藤 修, 作山晃裕, 戎 栄, 伊藤大亮, 須田千尋, 室谷嘉一, 上月正博
  • Organizer: 第4回日本腎臓リハビリテーション学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-03-29
• [Presentation] ラット腎におけるangiotensin IIによる脂肪酸ω水酸化酵素cytochrome P-450 4A発現への効果 (2014)
  • Author(s): 伊藤 修, 戎 栄, 胡 丐尊, 作山晃裕, 坂田佳子, 室谷嘉一, 上月正博
  • Organizer: 第26回腎と脂質研究会
  • Place of Presentation: 名古屋
• [Presentation] 高血圧自然発症ラットの血圧と腎nitric oxide合成酵素に対するpitavastatin長期投与の効果 (2014)
  • Author(s): 伊藤 修, 胡 丐尊, 戎 栄, 徐 斌, 作山晃裕, 坂田佳子, 伊藤大亮, 上月正博
  • Organizer: 第26回腎と脂質研究会
  • Place of Presentation: 名古屋
• [Presentation] 腎不全への運動療法：基礎的な検討から (2014)
  • Author(s): 伊藤 修,上月正博
  • Organizer: 第4回日本腎臓リハビリテーション学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Dahl食塩感受性ラットにおける長期的運動の腎保護作用－酸化ストレスとNOの観点から (2014)
  • Author(s): 坂田佳子, 伊藤 修, 作山晃裕, 戎 栄, 伊藤大亮, 須田千尋, 室谷嘉一, 上月正博
  • Organizer: 第4回日本腎臓リハビリテーション学会
  • Place of Presentation: 福岡
• [Presentation] 高血圧自然発症ラットの大動脈と腎における長期的運動によるNO 合成酵素の発現誘導に対するapocynin とallopurinol の影響 (2013)
  • Author(s): 伊藤 修, 曹 鵬宇, 作山晃裕, 伊藤大亮, 坂田佳子, 上月正博
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] 食塩感受性Dahl ラットの腎機能に対する長期的運動の効果 (2013)
  • Author(s): 坂田佳子, 伊藤 修, 作山晃裕, 戎 栄, 須田千尋, 室谷嘉一, 上月正博
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] Disorder of fatty acid oxidation in the kidney of rats with angiotensin II-induced hypertension (2013)
  • Author(s): Rong R, Ito O, Muroya Y, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2013 Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2013-09-12
• [Presentation] Renoprotective effects of exercise training in Dahl salt sensitive-rats (2013)
  • Author(s): Sakata Y, Ito O, Sakuyama A, Rong R, Ito D, Mori N, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2013 Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2013-09-12
• [Presentation] SOD mimetic tempol enhances exercise training-induced nitric oxide synthases in the kidney of spontaneously hypertensive rats (2013)
  • Author(s): Cao P, Ito O, Ito D, Rong R, Muroya Y, Sakuyama A, Sakata Y, Mori N, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
  • Year and Date: 2013-06-16
• [Presentation] Impacts of apocynin and allopurinol on exercise training-upregulated nitric oxide synthases in spontaneously hypertensive rats (2013)
  • Author(s): Cao P, Ito O, Sakuyama A, Ito D, Rong R, Muroya Y, Mori N, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
  • Year and Date: 2013-06-16
• [Presentation] Effects of exercise training and statin on triglyceride content and xanthine oxidoreductase in the liver of obese Zucker rats (2013)
  • Author(s): Sakuyama A, Ito O, Tan L, Sakata Y, Rong R, Ito D, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
  • Year and Date: 2013-06-16
• [Presentation] 長期的運動によるNO合成酵素への影響(その8)-心筋梗塞後心不全ラットにおける検討 (2013)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-13
• [Presentation] 5/6 腎摘腎不全ラットの血圧降下作用とNO排泄 (2013)
  • Author(s): 森 信芳, 須田千尋, 長坂 誠, 坂田佳子, 鈴木文歌, 高橋珠緒, 海老原覚, 伊藤 修, 上月正博
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-13
• [Presentation] Effects of chronic exercise on the cytochrome P-450 4A metabolism of arachidonic acid in the kidney of Dahl salt-sensitive rats (2013)
  • Author(s): Sakata Y, Ito O, Sakuyama A, Rong R, Kohzuki M
  • Organizer: WCN 2013 Satellite Symposium : Kidney and Lipids
  • Place of Presentation: Fukuoka
  • Year and Date: 2013-06-06
• [Presentation] Effects of atorvastatin and exercise on xanthine oxidase in the kidney and liver of Zucker fatty rats (2013)
  • Author(s): Sakuyama A, Ito O, Tan L, Sakata Y, Rong R, Kohzuki M
  • Organizer: WCN 2013 Satellite Symposium : Kidney and Lipids
  • Place of Presentation: Fukuoka
  • Year and Date: 2013-06-06
• [Presentation] Impact of apocynin and allopurinol on exercise training-induced nitric oxide synthases in the kidney of Wistar-Kyoto and spontaneously hypertensive rats (2013)
  • Author(s): Cao P, Ito O, Sakuyama A, Ito D, Rong R, Sakata Y, Muroya Y, Mori N, Kohzuki M.
  • Organizer: 7th World Congress of Nephrorogy
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2013-06-01
• [Presentation] 高血圧自然発症ラットのNO合成酵素への長期的運動とtempol の併用効果 (2013)
  • Author(s): 伊藤 修, 曹 鵬宇, 伊藤大亮, 室谷嘉一, 上月正博
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-11
• [Presentation] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron (2013)
  • Author(s): Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M
  • Organizer: International Symposium for Aldosteron and Related Substances in Hypertension
  • Place of Presentation: Sendai
  • Year and Date: 2013-04-27
• [Presentation] Eexpression of (pro)renin receptor by dehydration in the spontaneously hypertensive rat (2013)
  • Author(s): Tamura Y, Mori N, Ito O, Xu B, Rong R, Totsune K, Takahashi K, Kohzuki M
  • Organizer: International Symposium for Aldosteron and Related Substances in Hypertension
  • Place of Presentation: Sendai
  • Year and Date: 2013-04-27
• [Presentation] 長期的運動による腎nitric oxide 合成酵素の発現誘導に対するapocynin とallopurinol の影響 (2013)
  • Author(s): 作山晃裕, 曹 鵬宇, 伊藤大亮, 坂田佳子, 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2013-03-24
• [Presentation] 5/6 腎摘除慢性腎不全モデルラットでの降圧とNO産生に対する長期的運動効果の検討 (2013)
  • Author(s): 金 鍾宇, 森 信芳, 田村由馬, 中村貴裕, 徐 斌, 山越聖子, 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2013-03-24
• [Presentation] 腎疾患・高血圧モデルラットにおける長期的運動の効果 (2013)
  • Author(s): 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2013-03-23
• [Presentation] 腎での（プロ）レニン受容体発現の検討 (2013)
  • Author(s): 森 信芳, 伊藤 修, 戸恒和人,上月正博
  • Organizer: 第86回日本内分泌学会(仙台)
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Expression of (pro)renin receptor by dehydration in the spontaneously hypertensive rat (2013)
  • Author(s): Tamura Y, Mori N, Ito O, Xu B, Rong R, Totsune K, Takahashi K, Kohzuki M.
  • Organizer: International Symposium for Aldosteron and Related Substances in Hypertension
  • Place of Presentation: Sendai
• [Presentation] 高血圧自然発症ラットのNO合成酵素への長期的運動とtempolの併用効果 (2013)
  • Author(s): 伊藤 修, 曹 鵬宇, 伊藤大亮, 室谷嘉一, 上月正博
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
• [Presentation] （プロ）レニン受容体のラットネフロンにおける局在と高食塩摂取による発現調節 (2013)
  • Author(s): 伊藤 修, 戎 栄, 森 信芳, 森 建文, 伊藤貞嘉, 高橋和広, 戸恒和人, 上月正博
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
• [Presentation] 脱水による（プロ）レニンレセプターの発現；バゾプレッシン系の影響について (2013)
  • Author(s): 田村由馬, 伊藤 修, 高橋和広, 戸恒和人, 上月正博
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
• [Presentation] Impact of apocynin and allopurinol on exercise training-induced nitric oxide synthases in the kidney of Wistar-Kyoto and spontaneously hypertensive rats (2013)
  • Author(s): Cao P, Ito O, Sakuyama A, Ito D, Ron R, Sakata Y, Muroya Y, Mori N, Kohzuki M
  • Organizer: ISN World Congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron (2013)
  • Author(s): Rong R, Ito O, Mori N, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M
  • Organizer: ISN World Congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] The effect of pitavastatin on oxidative stress in spontaneously hypertensive rat (2013)
  • Author(s): Xu B, Mori N, Ito O, Tamura Y, Kohzuki M
  • Organizer: ISN World Congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Clofibrate ameliolates the disorder of fatty acid oxidation in the kidney of puromycin aminonucleotide-induced nephrotic rats (2013)
  • Author(s): Ito O, Muroya Y, Ron R, Takashima K, Ito D, Cao P, Kohzuki M
  • Organizer: WCN 2013 Satellite Symposium: Kidney and Lipids
  • Place of Presentation: Fukuoka
• [Presentation] Effects of chronic exercise on the cytochrome P-450 4A metabolism of arachidonic acid in the kidney of Dahl salt-sensitive rats (2013)
  • Author(s): Sakata Y, Ito O, Sakuyama A, Ron R, Kohzuki M
  • Organizer: WCN 2013 Satellite Symposium: Kidney and Lipids
  • Place of Presentation: Fukuoka
• [Presentation] Effects of atorvastatin and exercise on xanthine oxidase in the kidney and liver of Zucker fatty rats (2013)
  • Author(s): Sakuyama A, Ito O, Tan L, Sakata Y, Rong R, Kohzuki M
  • Organizer: WCN 2013 Satellite Symposium: Kidney and Lipids
  • Place of Presentation: Fukuoka
• [Presentation] 腎臓リハビリテーション (2013)
  • Author(s): 上月正博
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 肝臓リハビリテーション (2013)
  • Author(s): 伊藤 修
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 長期的運動によるNO合成酵素への影響(その8)－心筋梗塞後心不全ラットにおける検討 (2013)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
• [Presentation] 5/6腎摘腎不全ラットの血圧降下作用とNO排泄 (2013)
  • Author(s): 森 信芳, 須田千尋, 長坂 誠, 坂田佳子, 鈴木文歌，高橋珠緒，海老原覚, 伊藤 修, 上月正博
  • Organizer: 第50回日本リハビリテーション医学会
  • Place of Presentation: 東京
• [Presentation] Renal Rehabilitation in Japan (2013)
  • Author(s): Kohzuki M, Ito O
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
  • Invited
• [Presentation] Effects of exercise therapy on walking ability and health-related quality of life in patients with severe peripheral arterial disease (2013)
  • Author(s): Ito O, Kim MJ, Miura M, Kakihana T, Mori N, Nagasaka M, Ebihara S, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
• [Presentation] Effect of cardiac rehabilitation on exercise tolerance, instrumental activities of daily living (IADL) and quality of life (QOL) in severe heart failure treated with implantable left ventricular assist device (LVAD) (2013)
  • Author(s): Suzuki F, Ito O, Takahashi F, Mori N, Nagasaka M, Ebihara S, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
• [Presentation] The present situation of Phase II cardiac rehabilitation for acute myocardial infarction at clinics in Northern Japan (2013)
  • Author(s): Sakata Y, Ito O, Watanabe H, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
• [Presentation] Effect of exercise training for intermittent claudication due to incomplete persistent sciatic artery (2013)
  • Author(s): Kakihana T, Ito O, Suzuki F, Kohzuki M
  • Organizer: 7th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Beijing, China
• [Presentation] ネフローゼラット腎におけるアルブミン尿による脂肪酸酸化酵素の発現異常 (2013)
  • Author(s): 伊藤 修, 室谷嘉一, 戎 栄, 高島健太, 城 謙輔, 上月正博
  • Organizer: 第24回東北腎フォーラム
  • Place of Presentation: 仙台
• [Presentation] Dehydration upregulates the expression of full-length (pro)renin receptor in the kidney of Wistar-Kyoto rats and Spontaneously hypertensive rats (2013)
  • Author(s): Tamura Y, Ito O, Mori N, Rong R, Takahashi K, Totsune K, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2013 Scientific Sessions
  • Place of Presentation: New Orleans, USA
• [Presentation] 高血圧自然発症ラットの大動脈と腎における長期的運動によるNO合成酵素の発現誘導に対するapocyninとallopurinolの影響 (2013)
  • Author(s): 伊藤 修, 曹 鵬宇, 作山晃裕, 伊藤大亮, 坂田佳子, 上月正博
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] 食塩感受性Dahlラットの腎機能に対する長期的運動の効果 (2013)
  • Author(s): 坂田佳子, 伊藤 修, 作山晃裕, 戎 栄, 須田千尋, 室谷嘉一, 上月正博
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] 腎疾患・高血圧モデルラットにおける長期的運動の効果 (2013)
  • Author(s): 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮市
  • Invited
• [Presentation] 長期的運動による腎nitric oxide合成酵素の発現誘導に対するapocyninとallopurinolの影響 (2013)
  • Author(s): 作山晃裕, 曹 鵬宇, 伊藤大亮, 坂田佳子, 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮市
• [Presentation] 5/6腎摘除慢性腎不全モデルラットでの降圧とNO産生に対する長期的運動効果の検討 (2013)
  • Author(s): 金 鍾宇, 森 信芳, 田村由馬, 中村貴裕, 徐 斌, 山越聖子, 伊藤 修, 上月正博
  • Organizer: 第3回日本腎臓リハビリテーション学会
  • Place of Presentation: 宇都宮市
• [Presentation] 心不全における心腎連関と心臓リハビリテーション (2012)
  • Author(s): 伊藤 修
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-12-01
• [Presentation] 慢性心不全モデルラットにおける長期的運動のの心・腎一酸化窒素合成酵素に対する影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 森 信芳, 羽尾清貴, 下川宏明, 上月正博
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-11-30
• [Presentation] Effects of exercise training on nitric oxide synthases expresiion and phosphorylation in the kidney of spontaneously hypertensive rats (2012)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda T, Muroya Y, Takashima K, Ito S, Kohzuki M
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-10-01
• [Presentation] SOD mimetic tempol enhances exercise training-induced nitric oxide synthases in the kidney of spontaneously hypertensive rats (2012)
  • Author(s): Cao P, Ito O, Ito D, Rong R, Muroya Y, Sakuyama A, Sakata Y, Mori N, Kohzuki M
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-10-01
• [Presentation] The expression of (pro)renin receptor is upregulated in the kidney by high salt diet and NO inhibition (2012)
  • Author(s): Rong R, Ito O, Mori N, Tamura Y, Mori T, Ito S, Totsune K, Takahashi K, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-09-20
• [Presentation] Effects of valsartan and clofibrate on oxidative stress and fatty acid metabolism in the kidney of puromycin-induced nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Rong R, Sakata Y, Takashima K, Ito D, Cao P, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-09-20
• [Presentation] Alubuminuria causes disorder of cytochrome P450 metabolism of arachidonic acid in the kidney of nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Rong R, Sakata Y, Takashima K, Ito D, Cao P, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-09-20
• [Presentation] Impact of apocynin and allopurinol on exercise training-increased nitric oxide synthase activity and expression in the kidney of SHR and WKY (2012)
  • Author(s): Cao P, Ito O, Ito D, Sakuyama A, Rong R, Muroya Y, Sakata Y, Mori N, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-09-20
• [Presentation] 長期的運動が慢性心不全モデルラットの心・腎一酸化窒素合成酵素に及ぼす影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 森 信芳, 須田千尋, 羽尾清貴, 曹 鵬宇, 戎 栄, 下川宏明, 上月正博
  • Organizer: 第18回日本心臓リハビリテーション学会
  • Place of Presentation: さいたま
  • Year and Date: 2012-07-14
• [Presentation] 長期的運動によるNO 合成酵素への影響(その6)-NADPH oxidase 阻害薬との併用効果 (2012)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 室谷嘉一, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-01
• [Presentation] 長期的運動によるNO 合成酵素への影響(その7)-xanthine oxidase 阻害薬との併用効果 (2012)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 室谷嘉一, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-01
• [Presentation] 腎一酸化窒素系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 曹 鵬宇, 森 信芳, 須田千尋, 室谷嘉一, 高島健太, 上月正博
  • Organizer: 第2回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] 高血圧自然発症ラット腎における長期的運動のNO 産生と酸化ストレスへの効果 (2012)
  • Author(s): 曹 鵬宇, 伊藤 修, 伊藤大亮, 室谷嘉一, 戎 栄, 上月正博
  • Organizer: 第2回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] 5/6 腎摘除慢性腎不全モデルラットにおける, 長期的運動とG-CSFの併用療法が及ぼす腎保護効果 (2012)
  • Author(s): 須田千尋, 金澤雅之, 高島健太, 田村由馬, 坂田佳子, 森 信芳, 長坂 誠, 海老原覚, 伊藤 修, 上月正博
  • Organizer: 第2回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] 高血圧自然発症ラットの腎におけるプロレニン受容体発現への長期的運動の効果 (2012)
  • Author(s): 戎 栄, 伊藤 修, 森 信芳, 作山晃裕, 坂田佳子, 戸恒和人, 高橋和広, 上月正博
  • Organizer: 第2回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] 腎ネフロンセグメントにおける（プロ）レニン受容体の発現：高食塩食による調節 (2012)
  • Author(s): 戎 栄, 森 信芳, 伊藤 修, 森 建文, 伊藤貞嘉, 戸恒和人, 高橋和広, 上月正博
  • Organizer: 日本内分泌学会東北地方会
  • Place of Presentation: 仙台市
• [Presentation] 血圧と腎Nitric oxide系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 曹 鵬宇, 森 信芳, 上月正博
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸市
• [Presentation] 長期的運動によるNO合成酵素への影響(その6)－NADPH oxidase阻害薬との併用効果 (2012)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 室谷嘉一, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡市
• [Presentation] 長期的運動によるNO合成酵素への影響(その7)－xanthin oxidase阻害薬との併用効果 (2012)
  • Author(s): 伊藤 修, 伊藤大亮, 坂田佳子, 室谷嘉一, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡市
• [Presentation] 腎NO系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 曹 鵬宇, 森 信芳, 室谷喜一, 高島健太, 上月正博
  • Organizer: 第12回日本NO学会
  • Place of Presentation: 神戸市
• [Presentation] 長期的運動が慢性心不全モデルラットの心・腎一酸化窒素合成酵素に及ぼす影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 森 信芳, 須田千尋, 羽尾清貴, 曹 鵬宇, 戎 栄, 下川宏明, 上月正博
  • Organizer: 第18回日本心臓リハビリテーション学会
  • Place of Presentation: さいたま市
• [Presentation] The expression of (pro)renin receptor is upregulated in the kidney by high salt diet and NO inhibition (2012)
  • Author(s): Rong R, Ito O, Mori N, Tamura Y, Mori T, Ito S, Totsune K, Takahashi K, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: ワシントンDC、USA
• [Presentation] Effects of valsartan and clofibrate on oxidative stress and fatty acid metabolism in the kidney of puromycin-induced nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Ron R, Sakata Y, Takashima K, Ito D, Cao P, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: ワシントンDC、USA
• [Presentation] Alubuminuria causes disorder of cytochrome P450 metabolism of arachidonic acid in the kidney of nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Ron R, Sakata Y, Takashima K, Ito D, Cao P, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: ワシントンDC、USA
• [Presentation] Impact of apocynin and allopurinol on exercise training-increased nitric oxide synthase activity and expression in the kidney of SHR and WKY (2012)
  • Author(s): Cao P, Ito O, Ito D, Sakuyama A, Rong R, Muroya Y, Sakata Y, Mori N, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2012 Scientific Sessions
  • Place of Presentation: ワシントンDC、USA
• [Presentation] Effects of exercise training on nitric oxide synthases expresiion and phosphorylation in the kidney of spontaneously hypertensive rats (2012)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda T, Muroya Y, Takashima K, Ito S, Kohzuki M
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: シドニー、オーストラリア
• [Presentation] SOD mimetic tempol enhances exercise training-induced nitric oxide synthases in the kidney of spontaneously hypertensive rats (2012)
  • Author(s): Cao P, Ito O, Ito D, Ron R, Muroya Y, Sakuyama A, Sakata Y, Mori N, Kohzuki M
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: シドニー、オーストラリア
• [Presentation] 心不全における心腎連関と心臓リハビリテーション (2012)
  • Author(s): 伊藤 修
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] 慢性心不全モデルラットにおける長期的運動のの心・腎一酸化窒素合成酵素に対する影響 (2012)
  • Author(s): 伊藤大亮, 伊藤 修, 森 信芳, 羽尾清貴, 下川宏明, 上月正博
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台市
• [Presentation] 心腎連関 (2011)
  • Author(s): 伊藤 修
  • Organizer: 日本循環器看護学会
  • Place of Presentation: 仙台
  • Year and Date: 2011-11-12
• [Presentation] Impacts of apocynin and allopurinole on exercise training-induced nitric oxide synthases in the kidney of SHRs and WKYs (2011)
  • Author(s): Cao P, Ito O, Sakuyama A, Ito D, Rong R, Muroya Y, Mori N, Kohzuki M
  • Organizer: 13th China-Japan Joint Symposium on Hypertension
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-11-04
• [Presentation] Exercise training decreases the enhanced soluble (pro)renin receptor in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Rong R, Ito O, Mori N, Cao P, Totsune K, Takahashi K, Kohzuki M
  • Organizer: 13th China-Japan Joint Symposium on Hypertension
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-11-04
• [Presentation] 長期的運動によるNO合成酵素への影響(その5)-superoxide dismutase 類似薬の併用効果 (2011)
  • Author(s): 伊藤 修, 伊藤大亮, 須田千尋, 坂田佳子, 室谷嘉一, 森 信芳, 長坂 誠, 海老原覚, 上月正博
  • Organizer: 第48回日本リハビリテーション医学会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-02
• [Presentation] 長期的運動によるNO合成酵素への影響(その5)-superoxide dismutase類似薬の併用効果 (2011)
  • Author(s): 伊藤修, 伊藤大亮, 須田千尋, 坂田佳子, 室谷嘉一, 森信芳, 長坂誠, 海老原覚, 上月正博
  • Organizer: 第48回日本リハビリテーション医学会学術総会
  • Place of Presentation: 千葉県幕市
  • Year and Date: 2011-11-02
• [Presentation] SHR の血圧とNO 合成酵素に対する長期的運動とtempol の併用効果 (2011)
  • Author(s): 伊藤 修, 曹 鵬宇, 伊藤大亮, 室谷嘉一, 上月正博
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-21
• [Presentation] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果 (2011)
  • Author(s): 須田千尋, 金澤雅之, 姚 強, 高島健太, 坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-21
• [Presentation] Exercise training increases nitric oxide synthases in the kidney of rats with chronic heart failure (2011)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Rong R, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Organizer: 65th Annual Fall Conference and Scientific Session of the Council for High Blood Pressure Research
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-09-22
• [Presentation] SOD mimetic tempol enhances exercise training-induced nitric oxide synthases in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Cao P, Ito O, Ito D, Rong R, Muroya Y, Sakuyama A, Sakata Y, Mori N, Kohzuki M
  • Organizer: 65th Annual Fall Conference and Scientific Session of the Council for High Blood Pressure Research
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-09-22
• [Presentation] 高血圧自然発症ラットにおける長期的運動による腎・脈管NO 産生系の活性化 : 活性酸素生成系の関与 (2011)
  • Author(s): 伊藤 修, 曹 鵬宇, 伊藤大亮, 須田千尋, 作山晃裕, 坂田佳子, 三浦美佐, 上月正博
  • Organizer: 第36回日本運動療法学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-26
• [Presentation] Effects of exercise training on hydrogen peroxide and NO production (2011)
  • Author(s): Cao P, Ito O, Ito D, Muroya Y, Rong R, Sakuyama A, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2011-06-13
• [Presentation] Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats (2011)
  • Author(s): Suda T, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M, Ebihara S, Ito O, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2011-06-13
• [Presentation] Exercise training decreases the enhanced expression of soluble (pro)renin receptor in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Rong R, Ito O, Mori N, Cao P, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2011-06-13
• [Presentation] Effects of exercise training on the expression of angiotensin-converting enzyme in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Sakuyama A, Ito O, Cao P, Rong R, Ito D, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2011-06-13
• [Presentation] Effects of exercise training on hydrogen peroxide and NO production (2011)
  • Author(s): Cao P, Ito O, Ito D, Muroya Y, Ron R, Sakuyama A, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: 米国サンファン市
  • Year and Date: 2011-06-13
• [Presentation] Exercise training decreases the enhanced expression of soluble (pro)renin receptor in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Rone R, Ito O, Mori N, Cao P, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: 米国サンファン市
  • Year and Date: 2011-06-13
• [Presentation] Effects of exercise training on the expression of angiotensin-converting enzyme in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Sakuyama A, Ito O, Cao P, Ron R, Ito D, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: 米国サンファン市
  • Year and Date: 2011-06-13