Mouse model searching for timing of ombination of feeding and exercise on health science

• Project/Area Number: 23300278
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Waseda University
• Principal Investigator: SHIGENOBU Shibata 早稲田大学, 理工学術院, 教授 (10162629)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 体内時計 / 時間栄養学 / 時間運動学 / メタボリックシンドローム / 肝臓 / 肥満 / エネルギー代謝 / 摂食タイミング / 運動タイミング / 生活習慣病 / 運動 / 生活習慣 / インビボイメージング / イメージング / 時計遺伝子 / 食事パターン

Research Abstract

It is known that interaction of circadian clock and feeding/nutrition as for chrono-nutrition, and of circadian clock and exercise as for chrono-exercise. Combination of chrono-nutriton and chrono-exercise could determine the phase of liver circadian clock; 2 meals (morning and evening) per day advanced the liver rhythm, but wheel running in the morning attenuated the phase advance. Exercise in the evening rather than in the morning attenuated high fat diet-induced obesity with increasing energy metabolism. Feeding/exercise caused anti-obesity effect than exercise/feeding, suggesting that combination of timing of exercise/feeding is critical for anti-obesity.

Research Products

• [Journal Article] Circadian Regulation of Allergic Reaction by the Mast Cell Clock (2014)
  • Author(s): Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A
  • Journal Title: J Allergy Clin Immunol Volume: 133 Pages: 568-575
  • URL: http://www.jacionline.org/
  • Peer Reviewed
• [Journal Article] Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock (2013)
  • Author(s): Horikawa K, Fuji K, Fukazawa Y, Shibata S
  • Journal Title: J Pharmacol Sci Volume: 123 Pages: 402-406
  • NAID: 130003382618
  • URL: http://plaza.umin.ac.jp/~JPS1927/jps/index.html
  • Peer Reviewed
• [Journal Article] Chronobiology and nutrition (2013)
  • Author(s): Tahara Y., Shibata S
  • Journal Title: Neuroscience Volume: 253 Pages: 78-88
  • URL: http://www.journals.elsevier.com/neuroscience/
  • Peer Reviewed
• [Journal Article] Crosstalk between the circadian clock circuitry and the immune system (2013)
  • Author(s): Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G
  • Journal Title: Chronobiol Int Volume: 30 Pages: 870-888
  • URL: http://informahealthcare.com/loi/cbi
  • Peer Reviewed
• [Journal Article] Time-restricted feeding of rapidly digested starches causes stronger entrainment of the liver clock in PER2 : LUCIFERASE knock-in mice (2013)
  • Author(s): Itokawa M, Hirao A, Nagahama H, Otsuka M, Ohtsu T, Furutani N, Hirao K, Hatta T, Shibata S
  • Journal Title: Nutr Res Volume: 33 Pages: 109-119
  • URL: http://www.nrjournal.com/
  • Peer Reviewed
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice (2013)
  • Author(s): Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S
  • Journal Title: Br J Dermatol Volume: 168 Pages: 39-46
  • Peer Reviewed
• [Journal Article] Chronobiology and nutrition. (2013)
  • Author(s): Tahara Y., Shibata S.
  • Journal Title: Neuroscience Volume: 253 Pages: 78-88
  • Peer Reviewed
• [Journal Article] Meal frequency patterns determine the phase of mouse peripheral circadian clocks (2012)
  • Author(s): Kuroda H, Tahara Y, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S
  • Journal Title: Scientific Reports Volume: 2 Pages: 711-711
  • URL: http://www.nature.com/srep/index.html
  • Peer Reviewed
• [Journal Article] Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism (2012)
  • Author(s): Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S
  • Journal Title: J Circadian Rhythms Volume: 10(1) Pages: 4-4
  • URL: http://www.jcircadianrhythms.com/
  • Peer Reviewed
• [Journal Article] In vivo monitoring of peripheral circadian clocks in the mouse (2012)
  • Author(s): Tahara Y, Kuroda H, Saito K, Shibata S
  • Journal Title: Current Biology Volume: 22 Pages: 1029-34
  • URL: http://www.cell.com/current-biology/
  • Peer Reviewed
• [Journal Article] Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock (2012)
  • Author(s): Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J, Nishina H
  • Journal Title: J Biol Chem Volume: 287(11) Pages: 8318-26
  • URL: http://www.jbc.org/
  • Peer Reviewed
• [Journal Article] The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice (2012)
  • Author(s): Hirao A, Furutani N, Nagahama H, Itokawa M, Shibata S
  • Journal Title: Food Nutrition and Sciences Volume: 3(1) Pages: 40-47
  • URL: http://www.scirp.org/journal/fns/
  • Peer Reviewed
• [Journal Article] 2, 2, 2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2 : Luciferase knockin mice: lack of dependence on anesthetic activity (2012)
  • Author(s): Kubo Y, Tahara Y, Hirao A, Shibata S
  • Journal Title: J Pharmacol Exp Ther Volume: 340(3) Pages: 698-705
  • URL: http://jpet.aspetjournals.org/
  • Peer Reviewed
• [Journal Article] 時間栄養学 (2012)
  • Author(s): 柴田重信, 青木菜摘
  • Journal Title: 先端医学社 Volume: vol.20, no.5
  • NAID: 10031123205
• [Journal Article] 用語解説「時間栄養学」 (2012)
  • Author(s): 柴田重信
  • Journal Title: 栄養-評価と治療- Volume: Vol.29, No.3
• [Journal Article] 体内時計を用いた理想的な食生活作りのために (2012)
  • Author(s): 平尾彰子, 柴田重信
  • Journal Title: 顕微鏡 Volume: 第47巻 第2号 Pages: 83-86
  • NAID: 10030794049
  • URL: http://www.microscopy.or.jp/magazine/microscopy.html
• [Journal Article] 暮らしの最前線 90 「時間栄養学の現状とこれから」 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本家政学会誌 Volume: 第63巻 第6号 Pages: 337-341
  • Peer Reviewed
• [Journal Article] 時間栄養学, 化学と生物 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本農芸化学会誌
  • Peer Reviewed
• [Journal Article] 生体リズムと創薬 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本臨床薬理学会誌
  • NAID: 10030573970
• [Journal Article] 概日リズムと肥満・生活習慣病, 「体内時計と栄養・食事の相互作用」 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本肥満学会誌
  • URL: http://www.jasso.or.jp/contents/magazine/index.html
• [Journal Article] Meal frequency patterns determine the phase of mouse peripheral circadian clocks. (2012)
  • Author(s): Kuroda H^*, Tahara Y^*, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S
  • Journal Title: Scientific Reports Volume: 2 Issue: 1 Pages: 711-711
  • DOI: 10.1038/srep00711
  • Peer Reviewed
• [Journal Article] Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. (2012)
  • Author(s): Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S
  • Journal Title: Journal of Circadian Rhythms Volume: 10 Issue: 0 Pages: 4-4
  • DOI: 10.1186/1740-3391-10-4
  • Peer Reviewed
• [Journal Article] In Vivo Monitoring of Peripheral Circadian Clocks in the Mouse (2012)
  • Author(s): Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S
  • Journal Title: Current Biology Volume: 22 Issue: 11 Pages: 1029-1034
  • DOI: 10.1016/j.cub.2012.04.009
  • Peer Reviewed
• [Journal Article] Tribromoethanol phase shifts the circadian rhythm of the liver clock in Per2::Luciferase knock-in mice ; lack of dependence on anesthetic activity (2012)
  • Author(s): Kubo Y, Tahara Y, Hirao A, Shibata S
  • Journal Title: J Pharmacol Exp Ther Volume: 340 Pages: 698-705
  • Peer Reviewed
• [Journal Article] Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the manmalian circadian clock (2012)
  • Author(s): Uchida Y, Shibata S, Hirayama J, Nishina H
  • Journal Title: J Biol Chem Volume: 287 Pages: 8318-8326
  • Peer Reviewed
• [Journal Article] Synthesis of new [6]-gingerol analog and its protective effect on the development of metabolic syndrome in high-fat diet-fed mice (2011)
  • Author(s): Okamoto M, Shibata S, Shimzu I.
  • Journal Title: J.Medicinal Chemistry Volume: 54 Pages: 6295-6304
  • Peer Reviewed
• [Presentation] 時間栄養学 (2013)
  • Author(s): 柴田重信
  • Organizer: 第15回ダノン健康・栄養フォーラム
  • Place of Presentation: 有楽町朝日ホール, 東京
  • Year and Date: 2013-09-28
• [Presentation] 時間栄養学-免疫・炎症から代謝障害まで- (2013)
  • Author(s): 柴田重信
  • Organizer: 日本免疫食品学会, 第9回学術大会
  • Place of Presentation: 東京
• [Presentation] 時間栄養学に基づく生活習慣病予防 (2013)
  • Author(s): 柴田重信
  • Organizer: 日本体質医学会
  • Place of Presentation: 久留米市
• [Presentation] 時間栄養学とは何か (2013)
  • Author(s): 柴田重信
  • Organizer: 35回日本臨床栄養学会総会, 34回日本臨床栄養協会総会, 第11回大連合大会
  • Place of Presentation: 京都
• [Presentation] 時間栄養学―免疫・炎症から代謝障害までー (2013)
  • Author(s): 柴田重信
  • Organizer: 日本免疫食品学会、第９回学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 時間栄養学とは何か (2013)
  • Author(s): 柴田重信
  • Organizer: 35回日本臨床栄養学会総会、34回日本臨床栄養協会総会、第１１回大連合大会
  • Place of Presentation: 京都
  • Invited
• [Presentation] マウス体内時計遺伝子をリセットする食餌内容の研究 (2012)
  • Author(s): 柴田重信
  • Organizer: (財)飯島記念食品科学振興財団 第25回学術講演会
  • Place of Presentation: 東京(学士会館)
  • Year and Date: 2012-11-22
• [Presentation] 時間栄養学 -食の内容から食べ方まで- (2012)
  • Author(s): 柴田重信
  • Organizer: 第20回日本植物油協会 植物油栄養懇話会
  • Place of Presentation: 東京(如水会館)
  • Year and Date: 2012-11-09
• [Presentation] 時間栄養学～免疫・炎症から代謝障害まで～ (2012)
  • Author(s): 柴田重信
  • Organizer: 第5回基礎と臨床を結ぶ分子病態研究会
  • Place of Presentation: 東京(学士会館)
  • Year and Date: 2012-10-27
• [Presentation] 中枢神経系と肥満研究のフォロンティア「時間栄養学と肥満・代謝障害」 (2012)
  • Author(s): 柴田重信
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都(ホテルグランヴィア京都)
• [Presentation] インビボとインビトロで調べた末梢時計の相違と特徴 (2012)
  • Author(s): 柴田重信
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道(北海道大学学術交流会館)
• [Remarks]
  • URL: http://www.waseda.jp/sem-shibatas/